Diagnosis and management of smoldering multiple myeloma: the razor’s edge between clonality and cancer

Eli Muchtar, Shaji K. Kumar, Hila Magen, Morie A. Gertz

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Smoldering multiple myeloma (SMM) is a rare plasma cell disorder, and as the disease is asymptomatic, diagnosis is often incidental. SMM is characterized by increased marrow infiltration by clonal plasma cells and/or elevated serum M-protein in the absence of a myeloma-defining event (MDE). In recent years, SMM has gained increased attention owing to a broadening of the criteria for MDE, which include apart from the CRAB criteria, three additional parameters. Survival advantage may be offered by early treatment in the high-risk subset, based on a single trial. In this review, we assess the risk factors and models for progression to multiple myeloma. A review of our diagnostic and management approaches to SMM is presented.

Original languageEnglish (US)
Pages (from-to)288-299
Number of pages12
JournalLeukemia and Lymphoma
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • Risk
  • early intervention
  • models
  • progression
  • survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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