Diagnosis and Management of Barrett's Esophagus

Eric M. Nelsen; Robert H. Hawes; Prasad G. Iyer

doi:10.1016/j.suc.2012.07.009

Diagnosis and Management of Barrett's Esophagus

Eric M. Nelsen, Robert H. Hawes, Prasad G. Iyer

Gastroenterology and Hepatology

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Barrett esophagus is characterized by the replacement of squamous mucosa in the esophagus by specialized intestinal metaplasia. Its clinical significance lies in it being the strongest risk factor for and known precursor for esophageal adenocarcinoma. Diagnosis requires endoscopic confirmation of columnar metaplasia in the distal esophagus and histologic confirmation of specialized intestinal metaplasia. Recommendations for the management of subjects diagnosed with Barrett esophagus include periodic endoscopic surveillance to detect the development of high-grade dysplasia or adenocarcinoma. Careful endoscopic evaluation with high-resolution endoscopy and endoscopic resection is recommended in the evaluation of subjects with high-grade dysplasia and early adenocarcinoma.

Original language	English (US)
Pages (from-to)	1135-1154
Number of pages	20
Journal	Surgical Clinics of North America
Volume	92
Issue number	5
DOIs	https://doi.org/10.1016/j.suc.2012.07.009
State	Published - Oct 2012

Keywords

Ablation
Esophageal adenocarcinoma
Management
Pathogenesis
Screening

ASJC Scopus subject areas

Surgery

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10.1016/j.suc.2012.07.009

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title = "Diagnosis and Management of Barrett's Esophagus",

abstract = "Barrett esophagus is characterized by the replacement of squamous mucosa in the esophagus by specialized intestinal metaplasia. Its clinical significance lies in it being the strongest risk factor for and known precursor for esophageal adenocarcinoma. Diagnosis requires endoscopic confirmation of columnar metaplasia in the distal esophagus and histologic confirmation of specialized intestinal metaplasia. Recommendations for the management of subjects diagnosed with Barrett esophagus include periodic endoscopic surveillance to detect the development of high-grade dysplasia or adenocarcinoma. Careful endoscopic evaluation with high-resolution endoscopy and endoscopic resection is recommended in the evaluation of subjects with high-grade dysplasia and early adenocarcinoma.",

keywords = "Ablation, Esophageal adenocarcinoma, Management, Pathogenesis, Screening",

author = "Nelsen, {Eric M.} and Hawes, {Robert H.} and Iyer, {Prasad G.}",

note = "Funding Information: This work was supported by Grant No. RC4DK090413 from the National Institutes of Health , the American College of Gastroenterology , and the Mayo Foundation . ",

year = "2012",

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language = "English (US)",

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T1 - Diagnosis and Management of Barrett's Esophagus

AU - Nelsen, Eric M.

AU - Hawes, Robert H.

AU - Iyer, Prasad G.

N1 - Funding Information: This work was supported by Grant No. RC4DK090413 from the National Institutes of Health , the American College of Gastroenterology , and the Mayo Foundation .

PY - 2012/10

Y1 - 2012/10

N2 - Barrett esophagus is characterized by the replacement of squamous mucosa in the esophagus by specialized intestinal metaplasia. Its clinical significance lies in it being the strongest risk factor for and known precursor for esophageal adenocarcinoma. Diagnosis requires endoscopic confirmation of columnar metaplasia in the distal esophagus and histologic confirmation of specialized intestinal metaplasia. Recommendations for the management of subjects diagnosed with Barrett esophagus include periodic endoscopic surveillance to detect the development of high-grade dysplasia or adenocarcinoma. Careful endoscopic evaluation with high-resolution endoscopy and endoscopic resection is recommended in the evaluation of subjects with high-grade dysplasia and early adenocarcinoma.

AB - Barrett esophagus is characterized by the replacement of squamous mucosa in the esophagus by specialized intestinal metaplasia. Its clinical significance lies in it being the strongest risk factor for and known precursor for esophageal adenocarcinoma. Diagnosis requires endoscopic confirmation of columnar metaplasia in the distal esophagus and histologic confirmation of specialized intestinal metaplasia. Recommendations for the management of subjects diagnosed with Barrett esophagus include periodic endoscopic surveillance to detect the development of high-grade dysplasia or adenocarcinoma. Careful endoscopic evaluation with high-resolution endoscopy and endoscopic resection is recommended in the evaluation of subjects with high-grade dysplasia and early adenocarcinoma.

KW - Ablation

KW - Esophageal adenocarcinoma

KW - Management

KW - Pathogenesis

KW - Screening

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DO - 10.1016/j.suc.2012.07.009

M3 - Review article

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AN - SCOPUS:84866883437

SN - 0039-6109

VL - 92

SP - 1135

EP - 1154

JO - Surgical Clinics of North America

JF - Surgical Clinics of North America

IS - 5

ER -

Diagnosis and Management of Barrett's Esophagus

Abstract

Keywords

ASJC Scopus subject areas

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