Diagnosis and Management of Anaplastic Thyroid Cancer

Ashish V. Chintakuntlawar, Robert L. Foote, Jan L. Kasperbauer, Keith Christophe Bible

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Anaplastic thyroid cancer (ATC) is a devastating and usually incurable diagnosis. Clinical and pathologic diagnosis is best assessed at a tertiary center with concentrated ATC expertise. Expeditious multidisciplinary management is recommended for optimal patient outcomes. Based on multiinstitutional and population-based studies, multimodal therapy that includes chemoradiotherapy with surgery (when feasible) is the preferred initial treatment because it is associated with incrementally improved overall survival. In ATC that carries a BRAF V600E somatic mutation, combination therapy with BRAF and MEK inhibitors has shown promise but needs further study. Immunotherapeutic agents in neoadjuvant and metastatic settings are being investigated.

Original languageEnglish (US)
Pages (from-to)269-284
Number of pages16
JournalEndocrinology and Metabolism Clinics of North America
Volume48
Issue number1
DOIs
StatePublished - Mar 1 2019

Keywords

  • Anaplastic thyroid cancer
  • Chemoradiotherapy
  • Multimodality therapy
  • Systemic therapy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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