Diagnosis and genetic classification of multiple myeloma

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

INTRODUCTION In the past decade we have seen great advances in our understanding of the genetic abnormalities present in multiple myeloma (MM) cells, which is believed to be the culprit in the pathogenesis of this disease. This progress has been, in great Part, facilitated by the advent of novel molecular genetic and cytogenetic techniques, as well as the unparalleled power available through the genomic revolution. Furthermore, the continued testing for many of these genetic aberrations in large cohorts of patients has allowed for an increasingly accurate description of oncogenomics using primary patient samples. The translation and testing of this basic knowledge in these patient cohorts has provided clinical relevance that truly spans from the bench to the bedside. While much progress has been made in the understanding of the disease, many questions remain, Particularly those capable of addressing progression events from the benign stages and unraveling complex interactions supporting clonal survival and evolution. In this chapter we discuss the knowledge regarding a global overview of genetic aberrations of MM cells, primary genetic lesions, secondary genetic events, and, lastly, their clinical implications. GLOBAL OVERVIEW OF MM GENETICS At the top hierarchical level, human MM can be divided into two diseases: hyperdiploid MM (H-MM) and nonhyperdiploid MM (NH-MM). The dichotomy separation of MM into these two entities is appealing from the didactic perspective and is clearly substantiated by an extensive body of literature.

Original languageEnglish (US)
Title of host publicationTreatment of Multiple Myeloma and Related Disorders
PublisherCambridge University Press
Pages1-17
Number of pages17
Volume9780521515030
ISBN (Print)9780511551901, 9780521515030
DOIs
StatePublished - Jan 1 2008

Fingerprint

Multiple Myeloma
Clonal Evolution
Genetic Techniques
Polyploidy
Cytogenetic Analysis
Genetic Testing
Molecular Biology
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fonseca, R., & Bergsagel, P. L. (2008). Diagnosis and genetic classification of multiple myeloma. In Treatment of Multiple Myeloma and Related Disorders (Vol. 9780521515030, pp. 1-17). Cambridge University Press. https://doi.org/10.1017/CBO9780511551901.001

Diagnosis and genetic classification of multiple myeloma. / Fonseca, Rafael; Bergsagel, Peter Leif.

Treatment of Multiple Myeloma and Related Disorders. Vol. 9780521515030 Cambridge University Press, 2008. p. 1-17.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fonseca, R & Bergsagel, PL 2008, Diagnosis and genetic classification of multiple myeloma. in Treatment of Multiple Myeloma and Related Disorders. vol. 9780521515030, Cambridge University Press, pp. 1-17. https://doi.org/10.1017/CBO9780511551901.001
Fonseca R, Bergsagel PL. Diagnosis and genetic classification of multiple myeloma. In Treatment of Multiple Myeloma and Related Disorders. Vol. 9780521515030. Cambridge University Press. 2008. p. 1-17 https://doi.org/10.1017/CBO9780511551901.001
Fonseca, Rafael ; Bergsagel, Peter Leif. / Diagnosis and genetic classification of multiple myeloma. Treatment of Multiple Myeloma and Related Disorders. Vol. 9780521515030 Cambridge University Press, 2008. pp. 1-17
@inbook{7729bb1fbdca471e89becd06c4b2db3f,
title = "Diagnosis and genetic classification of multiple myeloma",
abstract = "INTRODUCTION In the past decade we have seen great advances in our understanding of the genetic abnormalities present in multiple myeloma (MM) cells, which is believed to be the culprit in the pathogenesis of this disease. This progress has been, in great Part, facilitated by the advent of novel molecular genetic and cytogenetic techniques, as well as the unparalleled power available through the genomic revolution. Furthermore, the continued testing for many of these genetic aberrations in large cohorts of patients has allowed for an increasingly accurate description of oncogenomics using primary patient samples. The translation and testing of this basic knowledge in these patient cohorts has provided clinical relevance that truly spans from the bench to the bedside. While much progress has been made in the understanding of the disease, many questions remain, Particularly those capable of addressing progression events from the benign stages and unraveling complex interactions supporting clonal survival and evolution. In this chapter we discuss the knowledge regarding a global overview of genetic aberrations of MM cells, primary genetic lesions, secondary genetic events, and, lastly, their clinical implications. GLOBAL OVERVIEW OF MM GENETICS At the top hierarchical level, human MM can be divided into two diseases: hyperdiploid MM (H-MM) and nonhyperdiploid MM (NH-MM). The dichotomy separation of MM into these two entities is appealing from the didactic perspective and is clearly substantiated by an extensive body of literature.",
author = "Rafael Fonseca and Bergsagel, {Peter Leif}",
year = "2008",
month = "1",
day = "1",
doi = "10.1017/CBO9780511551901.001",
language = "English (US)",
isbn = "9780511551901",
volume = "9780521515030",
pages = "1--17",
booktitle = "Treatment of Multiple Myeloma and Related Disorders",
publisher = "Cambridge University Press",

}

TY - CHAP

T1 - Diagnosis and genetic classification of multiple myeloma

AU - Fonseca, Rafael

AU - Bergsagel, Peter Leif

PY - 2008/1/1

Y1 - 2008/1/1

N2 - INTRODUCTION In the past decade we have seen great advances in our understanding of the genetic abnormalities present in multiple myeloma (MM) cells, which is believed to be the culprit in the pathogenesis of this disease. This progress has been, in great Part, facilitated by the advent of novel molecular genetic and cytogenetic techniques, as well as the unparalleled power available through the genomic revolution. Furthermore, the continued testing for many of these genetic aberrations in large cohorts of patients has allowed for an increasingly accurate description of oncogenomics using primary patient samples. The translation and testing of this basic knowledge in these patient cohorts has provided clinical relevance that truly spans from the bench to the bedside. While much progress has been made in the understanding of the disease, many questions remain, Particularly those capable of addressing progression events from the benign stages and unraveling complex interactions supporting clonal survival and evolution. In this chapter we discuss the knowledge regarding a global overview of genetic aberrations of MM cells, primary genetic lesions, secondary genetic events, and, lastly, their clinical implications. GLOBAL OVERVIEW OF MM GENETICS At the top hierarchical level, human MM can be divided into two diseases: hyperdiploid MM (H-MM) and nonhyperdiploid MM (NH-MM). The dichotomy separation of MM into these two entities is appealing from the didactic perspective and is clearly substantiated by an extensive body of literature.

AB - INTRODUCTION In the past decade we have seen great advances in our understanding of the genetic abnormalities present in multiple myeloma (MM) cells, which is believed to be the culprit in the pathogenesis of this disease. This progress has been, in great Part, facilitated by the advent of novel molecular genetic and cytogenetic techniques, as well as the unparalleled power available through the genomic revolution. Furthermore, the continued testing for many of these genetic aberrations in large cohorts of patients has allowed for an increasingly accurate description of oncogenomics using primary patient samples. The translation and testing of this basic knowledge in these patient cohorts has provided clinical relevance that truly spans from the bench to the bedside. While much progress has been made in the understanding of the disease, many questions remain, Particularly those capable of addressing progression events from the benign stages and unraveling complex interactions supporting clonal survival and evolution. In this chapter we discuss the knowledge regarding a global overview of genetic aberrations of MM cells, primary genetic lesions, secondary genetic events, and, lastly, their clinical implications. GLOBAL OVERVIEW OF MM GENETICS At the top hierarchical level, human MM can be divided into two diseases: hyperdiploid MM (H-MM) and nonhyperdiploid MM (NH-MM). The dichotomy separation of MM into these two entities is appealing from the didactic perspective and is clearly substantiated by an extensive body of literature.

UR - http://www.scopus.com/inward/record.url?scp=84926950699&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926950699&partnerID=8YFLogxK

U2 - 10.1017/CBO9780511551901.001

DO - 10.1017/CBO9780511551901.001

M3 - Chapter

AN - SCOPUS:84926950699

SN - 9780511551901

SN - 9780521515030

VL - 9780521515030

SP - 1

EP - 17

BT - Treatment of Multiple Myeloma and Related Disorders

PB - Cambridge University Press

ER -