Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors: An Expert Statement

Joseph Davar, Heidi M. Connolly, Martyn E. Caplin, Marianne Pavel, Jerome Zacks, Sanjeev Bhattacharyya, Daniel J. Cuthbertson, Rebecca Dobson, Simona Grozinsky-Glasberg, Richard P. Steeds, Giles Dreyfus, Patricia A. Pellikka, Christos Toumpanakis

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

Carcinoid heart disease is a frequent occurrence in patients with carcinoid syndrome and is responsible for substantial morbidity and mortality. The pathophysiology of carcinoid heart disease is poorly understood; however, chronic exposure to excessive circulating serotonin is considered one of the most important contributing factors. Despite recognition, international consensus guidelines specifically addressing the diagnosis and management of carcinoid heart disease are lacking. Furthermore, there is considerable variation in multiple aspects of screening and management of the disease. The aim of these guidelines was to provide succinct, practical advice on the diagnosis and management of carcinoid heart disease as well as its surveillance. Recommendations and proposed algorithms for the investigation, screening, and management have been developed based on an evidence-based review of the published data and on the expert opinion of a multidisciplinary consensus panel consisting of neuroendocrine tumor experts, including oncologists, gastroenterologists, and endocrinologists, in conjunction with cardiologists and cardiothoracic surgeons.

Original languageEnglish (US)
Pages (from-to)1288-1304
Number of pages17
JournalJournal of the American College of Cardiology
Volume69
Issue number10
DOIs
StatePublished - Mar 14 2017

Keywords

  • carcinoid syndrome
  • diagnosis
  • management
  • multidisciplinary
  • surveillance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Davar, J., Connolly, H. M., Caplin, M. E., Pavel, M., Zacks, J., Bhattacharyya, S., Cuthbertson, D. J., Dobson, R., Grozinsky-Glasberg, S., Steeds, R. P., Dreyfus, G., Pellikka, P. A., & Toumpanakis, C. (2017). Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors: An Expert Statement. Journal of the American College of Cardiology, 69(10), 1288-1304. https://doi.org/10.1016/j.jacc.2016.12.030