Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors: An Expert Statement

Joseph Davar, Heidi M. Connolly, Martyn E. Caplin, Marianne Pavel, Jerome Zacks, Sanjeev Bhattacharyya, Daniel J. Cuthbertson, Rebecca Dobson, Simona Grozinsky-Glasberg, Richard P. Steeds, Giles Dreyfus, Patricia Pellikka, Christos Toumpanakis

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Carcinoid heart disease is a frequent occurrence in patients with carcinoid syndrome and is responsible for substantial morbidity and mortality. The pathophysiology of carcinoid heart disease is poorly understood; however, chronic exposure to excessive circulating serotonin is considered one of the most important contributing factors. Despite recognition, international consensus guidelines specifically addressing the diagnosis and management of carcinoid heart disease are lacking. Furthermore, there is considerable variation in multiple aspects of screening and management of the disease. The aim of these guidelines was to provide succinct, practical advice on the diagnosis and management of carcinoid heart disease as well as its surveillance. Recommendations and proposed algorithms for the investigation, screening, and management have been developed based on an evidence-based review of the published data and on the expert opinion of a multidisciplinary consensus panel consisting of neuroendocrine tumor experts, including oncologists, gastroenterologists, and endocrinologists, in conjunction with cardiologists and cardiothoracic surgeons.

Original languageEnglish (US)
Pages (from-to)1288-1304
Number of pages17
JournalJournal of the American College of Cardiology
Volume69
Issue number10
DOIs
StatePublished - Mar 14 2017

Fingerprint

Carcinoid Heart Disease
Neoplasms
Guidelines
Neuroendocrine Tumors
Carcinoid Tumor
Expert Testimony
Disease Management
Serotonin
Morbidity
Mortality

Keywords

  • carcinoid syndrome
  • diagnosis
  • management
  • multidisciplinary
  • surveillance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Davar, J., Connolly, H. M., Caplin, M. E., Pavel, M., Zacks, J., Bhattacharyya, S., ... Toumpanakis, C. (2017). Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors: An Expert Statement. Journal of the American College of Cardiology, 69(10), 1288-1304. https://doi.org/10.1016/j.jacc.2016.12.030

Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors : An Expert Statement. / Davar, Joseph; Connolly, Heidi M.; Caplin, Martyn E.; Pavel, Marianne; Zacks, Jerome; Bhattacharyya, Sanjeev; Cuthbertson, Daniel J.; Dobson, Rebecca; Grozinsky-Glasberg, Simona; Steeds, Richard P.; Dreyfus, Giles; Pellikka, Patricia; Toumpanakis, Christos.

In: Journal of the American College of Cardiology, Vol. 69, No. 10, 14.03.2017, p. 1288-1304.

Research output: Contribution to journalReview article

Davar, J, Connolly, HM, Caplin, ME, Pavel, M, Zacks, J, Bhattacharyya, S, Cuthbertson, DJ, Dobson, R, Grozinsky-Glasberg, S, Steeds, RP, Dreyfus, G, Pellikka, P & Toumpanakis, C 2017, 'Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors: An Expert Statement', Journal of the American College of Cardiology, vol. 69, no. 10, pp. 1288-1304. https://doi.org/10.1016/j.jacc.2016.12.030
Davar, Joseph ; Connolly, Heidi M. ; Caplin, Martyn E. ; Pavel, Marianne ; Zacks, Jerome ; Bhattacharyya, Sanjeev ; Cuthbertson, Daniel J. ; Dobson, Rebecca ; Grozinsky-Glasberg, Simona ; Steeds, Richard P. ; Dreyfus, Giles ; Pellikka, Patricia ; Toumpanakis, Christos. / Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors : An Expert Statement. In: Journal of the American College of Cardiology. 2017 ; Vol. 69, No. 10. pp. 1288-1304.
@article{9a577e565c0f43cb80f1f34f4b35702e,
title = "Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors: An Expert Statement",
abstract = "Carcinoid heart disease is a frequent occurrence in patients with carcinoid syndrome and is responsible for substantial morbidity and mortality. The pathophysiology of carcinoid heart disease is poorly understood; however, chronic exposure to excessive circulating serotonin is considered one of the most important contributing factors. Despite recognition, international consensus guidelines specifically addressing the diagnosis and management of carcinoid heart disease are lacking. Furthermore, there is considerable variation in multiple aspects of screening and management of the disease. The aim of these guidelines was to provide succinct, practical advice on the diagnosis and management of carcinoid heart disease as well as its surveillance. Recommendations and proposed algorithms for the investigation, screening, and management have been developed based on an evidence-based review of the published data and on the expert opinion of a multidisciplinary consensus panel consisting of neuroendocrine tumor experts, including oncologists, gastroenterologists, and endocrinologists, in conjunction with cardiologists and cardiothoracic surgeons.",
keywords = "carcinoid syndrome, diagnosis, management, multidisciplinary, surveillance",
author = "Joseph Davar and Connolly, {Heidi M.} and Caplin, {Martyn E.} and Marianne Pavel and Jerome Zacks and Sanjeev Bhattacharyya and Cuthbertson, {Daniel J.} and Rebecca Dobson and Simona Grozinsky-Glasberg and Steeds, {Richard P.} and Giles Dreyfus and Patricia Pellikka and Christos Toumpanakis",
year = "2017",
month = "3",
day = "14",
doi = "10.1016/j.jacc.2016.12.030",
language = "English (US)",
volume = "69",
pages = "1288--1304",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "10",

}

TY - JOUR

T1 - Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors

T2 - An Expert Statement

AU - Davar, Joseph

AU - Connolly, Heidi M.

AU - Caplin, Martyn E.

AU - Pavel, Marianne

AU - Zacks, Jerome

AU - Bhattacharyya, Sanjeev

AU - Cuthbertson, Daniel J.

AU - Dobson, Rebecca

AU - Grozinsky-Glasberg, Simona

AU - Steeds, Richard P.

AU - Dreyfus, Giles

AU - Pellikka, Patricia

AU - Toumpanakis, Christos

PY - 2017/3/14

Y1 - 2017/3/14

N2 - Carcinoid heart disease is a frequent occurrence in patients with carcinoid syndrome and is responsible for substantial morbidity and mortality. The pathophysiology of carcinoid heart disease is poorly understood; however, chronic exposure to excessive circulating serotonin is considered one of the most important contributing factors. Despite recognition, international consensus guidelines specifically addressing the diagnosis and management of carcinoid heart disease are lacking. Furthermore, there is considerable variation in multiple aspects of screening and management of the disease. The aim of these guidelines was to provide succinct, practical advice on the diagnosis and management of carcinoid heart disease as well as its surveillance. Recommendations and proposed algorithms for the investigation, screening, and management have been developed based on an evidence-based review of the published data and on the expert opinion of a multidisciplinary consensus panel consisting of neuroendocrine tumor experts, including oncologists, gastroenterologists, and endocrinologists, in conjunction with cardiologists and cardiothoracic surgeons.

AB - Carcinoid heart disease is a frequent occurrence in patients with carcinoid syndrome and is responsible for substantial morbidity and mortality. The pathophysiology of carcinoid heart disease is poorly understood; however, chronic exposure to excessive circulating serotonin is considered one of the most important contributing factors. Despite recognition, international consensus guidelines specifically addressing the diagnosis and management of carcinoid heart disease are lacking. Furthermore, there is considerable variation in multiple aspects of screening and management of the disease. The aim of these guidelines was to provide succinct, practical advice on the diagnosis and management of carcinoid heart disease as well as its surveillance. Recommendations and proposed algorithms for the investigation, screening, and management have been developed based on an evidence-based review of the published data and on the expert opinion of a multidisciplinary consensus panel consisting of neuroendocrine tumor experts, including oncologists, gastroenterologists, and endocrinologists, in conjunction with cardiologists and cardiothoracic surgeons.

KW - carcinoid syndrome

KW - diagnosis

KW - management

KW - multidisciplinary

KW - surveillance

UR - http://www.scopus.com/inward/record.url?scp=85014475545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014475545&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2016.12.030

DO - 10.1016/j.jacc.2016.12.030

M3 - Review article

C2 - 28279296

AN - SCOPUS:85014475545

VL - 69

SP - 1288

EP - 1304

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 10

ER -