Diadenosine 5',5-P1,P5-pentaphosphate harbors the properties of a signaling molecule in the heart

Aleksandar Jovanovic, Sofija Jovanovic, Dennis C. Mays, James J. Lipsky, Andre Terzic

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Dinucleotide polyphosphates (ApnA) have emerged as signaling molecules in rapidly dividing cells. The presence and role of Ap5A in the heart remain unknown. Here, we report that the myocardium contains abundant amounts of diadenosine 5',5-(P)1,P5-pentaphosphate (Ap5A), a member of the ApnA family. Ischemia induced 10-fold decrease in the myocardial concentration of Ap5A. A target of Ap5A action was identified to be the cardiac ATP-sensitive K+ (K(ATP)) channel, a metabolismsensitive ion conductance activated in ischemia. At levels found in hearts prior to ischemia, Ap5A maintained a low probability of KATe channel opening, but at levels found in hearts following ischemia, Ap5A allowed a high probability of K(ATP) channel opening. Taken together, the present data suggest that Ap5A harbors the properties of a signaling molecule involved in the cardiac response to metabolic stress.

Original languageEnglish (US)
Pages (from-to)314-318
Number of pages5
JournalFEBS Letters
Volume423
Issue number3
DOIs
StatePublished - Feb 27 1998

Keywords

  • Diadenosine pentaphosphate
  • Diadenosine polyphosphate
  • Heart
  • Ischemia
  • K(ATP) channel

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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