Diabetic neuropathies

Phillip Anson Low, G. A. Suarez

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

There is a family of diabetic neuropathies that mimic the entire spectrum of peripheral neuropathies. Distal sensory neuropathy is the most common. In small-fibre neuropathy, autonomic failure and loss of sense of pain and temperature are prominent. Painfulness is seen in a number of diabetic neuropathies. The asymmetric neuropathies are distinctive and are probably caused by a combination of microvascular and immune-mediated mechanisms. The pathogenesis of diabetic neuropathy is probably multifactorial. Hyperglycaemia is central to any pathogenic scheme whereby nerve blood flow is reduced by an effect on microvessels mediated by perturbations such as oxidative stress, reduction of nitric oxide, prostaglandins and an increase in endothelin. It may also affect nerve fibres directly. Recent clinical trials have clearly demonstrated the importance of strict glycaemic control. There is also support for essential fatty acids, antioxidants and aldose reductase inhibitors. Treatment of diabetic neuropathy is focused on improving glycaemic control and treatment of symptoms. The precise role of other modalities of treatment of diabetic neuropathy remain to be firmly established.

Original languageEnglish (US)
Pages (from-to)401-425
Number of pages25
JournalBailliere's Clinical Neurology
Volume4
Issue number3
StatePublished - 1995

Fingerprint

Diabetic Neuropathies
Thermosensing
Aldehyde Reductase
Essential Fatty Acids
Endothelins
Peripheral Nervous System Diseases
Microvessels
Nerve Fibers
Hyperglycemia
Prostaglandins
Nitric Oxide
Oxidative Stress
Therapeutics
Antioxidants
Clinical Trials
Pain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Low, P. A., & Suarez, G. A. (1995). Diabetic neuropathies. Bailliere's Clinical Neurology, 4(3), 401-425.

Diabetic neuropathies. / Low, Phillip Anson; Suarez, G. A.

In: Bailliere's Clinical Neurology, Vol. 4, No. 3, 1995, p. 401-425.

Research output: Contribution to journalArticle

Low, PA & Suarez, GA 1995, 'Diabetic neuropathies', Bailliere's Clinical Neurology, vol. 4, no. 3, pp. 401-425.
Low, Phillip Anson ; Suarez, G. A. / Diabetic neuropathies. In: Bailliere's Clinical Neurology. 1995 ; Vol. 4, No. 3. pp. 401-425.
@article{a39c4bda88eb4e23b28cfa080647f9f3,
title = "Diabetic neuropathies",
abstract = "There is a family of diabetic neuropathies that mimic the entire spectrum of peripheral neuropathies. Distal sensory neuropathy is the most common. In small-fibre neuropathy, autonomic failure and loss of sense of pain and temperature are prominent. Painfulness is seen in a number of diabetic neuropathies. The asymmetric neuropathies are distinctive and are probably caused by a combination of microvascular and immune-mediated mechanisms. The pathogenesis of diabetic neuropathy is probably multifactorial. Hyperglycaemia is central to any pathogenic scheme whereby nerve blood flow is reduced by an effect on microvessels mediated by perturbations such as oxidative stress, reduction of nitric oxide, prostaglandins and an increase in endothelin. It may also affect nerve fibres directly. Recent clinical trials have clearly demonstrated the importance of strict glycaemic control. There is also support for essential fatty acids, antioxidants and aldose reductase inhibitors. Treatment of diabetic neuropathy is focused on improving glycaemic control and treatment of symptoms. The precise role of other modalities of treatment of diabetic neuropathy remain to be firmly established.",
author = "Low, {Phillip Anson} and Suarez, {G. A.}",
year = "1995",
language = "English (US)",
volume = "4",
pages = "401--425",
journal = "Bailliere's Clinical Neurology",
issn = "0961-0421",
publisher = "Bailliere Tindall Ltd",
number = "3",

}

TY - JOUR

T1 - Diabetic neuropathies

AU - Low, Phillip Anson

AU - Suarez, G. A.

PY - 1995

Y1 - 1995

N2 - There is a family of diabetic neuropathies that mimic the entire spectrum of peripheral neuropathies. Distal sensory neuropathy is the most common. In small-fibre neuropathy, autonomic failure and loss of sense of pain and temperature are prominent. Painfulness is seen in a number of diabetic neuropathies. The asymmetric neuropathies are distinctive and are probably caused by a combination of microvascular and immune-mediated mechanisms. The pathogenesis of diabetic neuropathy is probably multifactorial. Hyperglycaemia is central to any pathogenic scheme whereby nerve blood flow is reduced by an effect on microvessels mediated by perturbations such as oxidative stress, reduction of nitric oxide, prostaglandins and an increase in endothelin. It may also affect nerve fibres directly. Recent clinical trials have clearly demonstrated the importance of strict glycaemic control. There is also support for essential fatty acids, antioxidants and aldose reductase inhibitors. Treatment of diabetic neuropathy is focused on improving glycaemic control and treatment of symptoms. The precise role of other modalities of treatment of diabetic neuropathy remain to be firmly established.

AB - There is a family of diabetic neuropathies that mimic the entire spectrum of peripheral neuropathies. Distal sensory neuropathy is the most common. In small-fibre neuropathy, autonomic failure and loss of sense of pain and temperature are prominent. Painfulness is seen in a number of diabetic neuropathies. The asymmetric neuropathies are distinctive and are probably caused by a combination of microvascular and immune-mediated mechanisms. The pathogenesis of diabetic neuropathy is probably multifactorial. Hyperglycaemia is central to any pathogenic scheme whereby nerve blood flow is reduced by an effect on microvessels mediated by perturbations such as oxidative stress, reduction of nitric oxide, prostaglandins and an increase in endothelin. It may also affect nerve fibres directly. Recent clinical trials have clearly demonstrated the importance of strict glycaemic control. There is also support for essential fatty acids, antioxidants and aldose reductase inhibitors. Treatment of diabetic neuropathy is focused on improving glycaemic control and treatment of symptoms. The precise role of other modalities of treatment of diabetic neuropathy remain to be firmly established.

UR - http://www.scopus.com/inward/record.url?scp=0028818372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028818372&partnerID=8YFLogxK

M3 - Article

VL - 4

SP - 401

EP - 425

JO - Bailliere's Clinical Neurology

JF - Bailliere's Clinical Neurology

SN - 0961-0421

IS - 3

ER -