Diabetes Mellitus Is Associated With an Exocrine Pancreatopathy: Conclusions From a Review of Literature

Sonmoon Mohapatra, Shounak Majumder, Thomas Christopher Smyrk, Lizhi Zhang, Aleksey V Matveyenko, Yogish C Kudva, Suresh T Chari

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

OBJECTIVE: Abnormalities in exocrine pancreatic function have been reported in diabetes mellitus (DM). We reviewed published literature to determine the nature of structural and functional alterations in the exocrine pancreas in DM. METHODS: We identified and abstracted data from original studies (n = 50) describing morphological, structural, and functional changes in the exocrine pancreas in types 1 and 2 DM. RESULTS: Pancreatic weight and volume are markedly lower in type 1 DM (P <0.005) with insignificant decrease in type 2 DM compared with age-, sex-, and body mass index–matched controls. Pancreatic histopathological changes seen in most subjects with DM at autopsy (n = 7 studies, 1272 autopsies) include mild-to-marked interacinar fibrosis, scant inflammatory infiltrate, no pancreatic ductal changes, and hyalinization of arteries. In subjects with DM, pooled prevalence of decreased fecal elastase 1 (

Original languageEnglish (US)
JournalPancreas
DOIs
StateAccepted/In press - Feb 26 2016

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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