Diabetes Mellitus, Hyperglycemia, Hemoglobin A1C and the Risk of Prosthetic Joint Infections in Total Hip and Knee Arthroplasty

Hilal Maradit Kremers, Laura W. Lewallen, Tad M. Mabry, Daniel J. Berry, Elie F. Berbari, Douglas R. Osmon

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

Diabetes mellitus is an established risk factor for infections but evidence is conflicting to what extent perioperative hyperglycemia, glycemic control and treatment around the time of surgery modify the risk of prosthetic joint infections (PJIs). In a cohort of 20,171 total hip and knee arthroplasty procedures, we observed a significantly higher risk of PJIs among patients with a diagnosis of diabetes mellitus (hazard ratio [HR] 1.55, 95% CI 1.11, 2.16), patients using diabetes medications (HR 1.56, 95% CI 1.08, 2.25) and patients with perioperative hyperglycemia (HR 1.59, 95% CI 1.07, 2.35), but the effects were attenuated after adjusting for body mass index, type of surgery, ASA score and operative time. Although data were limited, there was no association between hemoglobin A1c values and PJIs.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalJournal of Arthroplasty
Volume30
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Diabetes mellitus
  • Hemoglobin A1c
  • Hyperglycemia
  • Infection
  • Total joint arthroplasty

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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