Diabetes Mellitus and the Risk of Urinary Tract Stones: A Population-Based Case-Control Study

John C Lieske, Lourdes S Peña de la Vega, Matthew T. Gettman, Jeffrey M. Slezak, Eric J. Bergstralh, L. Joseph Melton, Cynthia L. Leibson

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Background: Because nephrolithiasis has been associated with obesity, an important risk factor for type 2 diabetes mellitus (DM), we tested the hypothesis that DM prevalence is increased in individuals who develop renal stones. Methods: In an initial electronic analysis, prior diagnoses of DM, hypertension, and obesity were compared between all Olmsted County, MN, residents with a diagnosis code for nephrolithiasis between 1980 and 1999 and matched residents of similar age and sex (N = 3,561 case-control pairs). A random sample of 260 cases and corresponding controls was selected for detailed medical record review to confirm and characterize the stone event and obtain heights, weights, blood pressures, and glucose and cholesterol values. Results: In the electronic analysis, unadjusted odds ratios (ORs) for DM (OR, 1.29; 95% confidence interval [CI], 1.09 to 1.53), obesity (OR, 1.15; 95% CI, 1.02 to 1.31), and hypertension (OR, 1.19; 95% CI, 1.04 to 1.35) were increased significantly for nephrolithiasis cases versus controls; DM remained significant after adjustment for age, sex, calendar year, hypertension, and obesity (OR, 1.22; 95% CI, 1.03 to 1.46). Detailed record review of a subset showed significant increases for cases versus controls for body mass index (OR, 1.05; 95% CI, 1.01 to -1.09) and hypertension (OR, 1.71; 95% CI, 1.17 to 2.59). Odds for DM were increased, but not significantly, in the subsample (OR, 1.44; 95% CI, 0.76 to 2.72). Among cases with stone analyses, those with uric acid stones (n = 10) had a greater percentage of DM compared with those with all other stone types (n = 112; 40% versus 9%; P = 0.02). Conclusion: Findings from this population-based study suggest that DM, obesity, and hypertension are associated with nephrolithiasis, and DM may be a factor in the development of uric acid stones.

Original languageEnglish (US)
Pages (from-to)897-904
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume48
Issue number6
DOIs
StatePublished - Dec 2006

Fingerprint

Urinary Calculi
Case-Control Studies
Diabetes Mellitus
Odds Ratio
Nephrolithiasis
Confidence Intervals
Obesity
Population
Hypertension
Uric Acid
Type 2 Diabetes Mellitus
Medical Records
Blood Glucose
Body Mass Index
Cholesterol
Blood Pressure
Kidney
Weights and Measures

Keywords

  • Diabetes
  • hypertension
  • nephrolithiasis
  • obesity
  • uric acid

ASJC Scopus subject areas

  • Nephrology

Cite this

Lieske, J. C., de la Vega, L. S. P., Gettman, M. T., Slezak, J. M., Bergstralh, E. J., Melton, L. J., & Leibson, C. L. (2006). Diabetes Mellitus and the Risk of Urinary Tract Stones: A Population-Based Case-Control Study. American Journal of Kidney Diseases, 48(6), 897-904. https://doi.org/10.1053/j.ajkd.2006.09.002

Diabetes Mellitus and the Risk of Urinary Tract Stones : A Population-Based Case-Control Study. / Lieske, John C; de la Vega, Lourdes S Peña; Gettman, Matthew T.; Slezak, Jeffrey M.; Bergstralh, Eric J.; Melton, L. Joseph; Leibson, Cynthia L.

In: American Journal of Kidney Diseases, Vol. 48, No. 6, 12.2006, p. 897-904.

Research output: Contribution to journalArticle

Lieske, JC, de la Vega, LSP, Gettman, MT, Slezak, JM, Bergstralh, EJ, Melton, LJ & Leibson, CL 2006, 'Diabetes Mellitus and the Risk of Urinary Tract Stones: A Population-Based Case-Control Study', American Journal of Kidney Diseases, vol. 48, no. 6, pp. 897-904. https://doi.org/10.1053/j.ajkd.2006.09.002
Lieske, John C ; de la Vega, Lourdes S Peña ; Gettman, Matthew T. ; Slezak, Jeffrey M. ; Bergstralh, Eric J. ; Melton, L. Joseph ; Leibson, Cynthia L. / Diabetes Mellitus and the Risk of Urinary Tract Stones : A Population-Based Case-Control Study. In: American Journal of Kidney Diseases. 2006 ; Vol. 48, No. 6. pp. 897-904.
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