Diabetes and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium

Joanne W. Elena, Emily Steplowski, Kai Yu, Patricia Hartge, Geoffrey S. Tobias, Michelle J. Brotzman, Stephen J. Chanock, Rachael Z. Stolzenberg-Solomon, Alan A. Arslan, H. Bas Bueno-De-Mesquita, Kathy Helzlsouer, Eric J. Jacobs, Andrea Lacroix, Gloria M Petersen, Wei Zheng, Demetrius Albanes, Naomi E. Allen, Laufey Amundadottir, Ying Bao, Heiner BoeingMarie Christine Boutron-Ruault, Julie E. Buring, J. Michael Gaziano, Edward L. Giovannucci, Eric J. Duell, Göran Hallmans, Barbara V. Howard, David J. Hunter, Amy Hutchinson, Kevin B. Jacobs, Charles Kooperberg, Peter Kraft, Julie B. Mendelsohn, Dominique S. Michaud, Domenico Palli, Lawrence S. Phillips, Kim Overvad, Alpa V. Patel, Leah Sansbury, Xiao Ou Shu, Michael S. Simon, Nadia Slimani, Dimitrios Trichopoulos, Kala Visvanathan, Jarmo Virtamo, Brian M. Wolpin, Anne Zeleniuch-Jacquotte, Charles S. Fuchs, Robert N. Hoover, Myron Gross

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.

Original languageEnglish (US)
Pages (from-to)13-25
Number of pages13
JournalCancer Causes and Control
Volume24
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Pancreatic Neoplasms
Adenocarcinoma
Case-Control Studies
Smoking
Alcohols

Keywords

  • Cohort consortium
  • Diabetes
  • Pancreatic cancer
  • Risk factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Elena, J. W., Steplowski, E., Yu, K., Hartge, P., Tobias, G. S., Brotzman, M. J., ... Gross, M. (2013). Diabetes and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium. Cancer Causes and Control, 24(1), 13-25. https://doi.org/10.1007/s10552-012-0078-8

Diabetes and risk of pancreatic cancer : A pooled analysis from the pancreatic cancer cohort consortium. / Elena, Joanne W.; Steplowski, Emily; Yu, Kai; Hartge, Patricia; Tobias, Geoffrey S.; Brotzman, Michelle J.; Chanock, Stephen J.; Stolzenberg-Solomon, Rachael Z.; Arslan, Alan A.; Bueno-De-Mesquita, H. Bas; Helzlsouer, Kathy; Jacobs, Eric J.; Lacroix, Andrea; Petersen, Gloria M; Zheng, Wei; Albanes, Demetrius; Allen, Naomi E.; Amundadottir, Laufey; Bao, Ying; Boeing, Heiner; Boutron-Ruault, Marie Christine; Buring, Julie E.; Gaziano, J. Michael; Giovannucci, Edward L.; Duell, Eric J.; Hallmans, Göran; Howard, Barbara V.; Hunter, David J.; Hutchinson, Amy; Jacobs, Kevin B.; Kooperberg, Charles; Kraft, Peter; Mendelsohn, Julie B.; Michaud, Dominique S.; Palli, Domenico; Phillips, Lawrence S.; Overvad, Kim; Patel, Alpa V.; Sansbury, Leah; Shu, Xiao Ou; Simon, Michael S.; Slimani, Nadia; Trichopoulos, Dimitrios; Visvanathan, Kala; Virtamo, Jarmo; Wolpin, Brian M.; Zeleniuch-Jacquotte, Anne; Fuchs, Charles S.; Hoover, Robert N.; Gross, Myron.

In: Cancer Causes and Control, Vol. 24, No. 1, 01.2013, p. 13-25.

Research output: Contribution to journalArticle

Elena, JW, Steplowski, E, Yu, K, Hartge, P, Tobias, GS, Brotzman, MJ, Chanock, SJ, Stolzenberg-Solomon, RZ, Arslan, AA, Bueno-De-Mesquita, HB, Helzlsouer, K, Jacobs, EJ, Lacroix, A, Petersen, GM, Zheng, W, Albanes, D, Allen, NE, Amundadottir, L, Bao, Y, Boeing, H, Boutron-Ruault, MC, Buring, JE, Gaziano, JM, Giovannucci, EL, Duell, EJ, Hallmans, G, Howard, BV, Hunter, DJ, Hutchinson, A, Jacobs, KB, Kooperberg, C, Kraft, P, Mendelsohn, JB, Michaud, DS, Palli, D, Phillips, LS, Overvad, K, Patel, AV, Sansbury, L, Shu, XO, Simon, MS, Slimani, N, Trichopoulos, D, Visvanathan, K, Virtamo, J, Wolpin, BM, Zeleniuch-Jacquotte, A, Fuchs, CS, Hoover, RN & Gross, M 2013, 'Diabetes and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium', Cancer Causes and Control, vol. 24, no. 1, pp. 13-25. https://doi.org/10.1007/s10552-012-0078-8
Elena, Joanne W. ; Steplowski, Emily ; Yu, Kai ; Hartge, Patricia ; Tobias, Geoffrey S. ; Brotzman, Michelle J. ; Chanock, Stephen J. ; Stolzenberg-Solomon, Rachael Z. ; Arslan, Alan A. ; Bueno-De-Mesquita, H. Bas ; Helzlsouer, Kathy ; Jacobs, Eric J. ; Lacroix, Andrea ; Petersen, Gloria M ; Zheng, Wei ; Albanes, Demetrius ; Allen, Naomi E. ; Amundadottir, Laufey ; Bao, Ying ; Boeing, Heiner ; Boutron-Ruault, Marie Christine ; Buring, Julie E. ; Gaziano, J. Michael ; Giovannucci, Edward L. ; Duell, Eric J. ; Hallmans, Göran ; Howard, Barbara V. ; Hunter, David J. ; Hutchinson, Amy ; Jacobs, Kevin B. ; Kooperberg, Charles ; Kraft, Peter ; Mendelsohn, Julie B. ; Michaud, Dominique S. ; Palli, Domenico ; Phillips, Lawrence S. ; Overvad, Kim ; Patel, Alpa V. ; Sansbury, Leah ; Shu, Xiao Ou ; Simon, Michael S. ; Slimani, Nadia ; Trichopoulos, Dimitrios ; Visvanathan, Kala ; Virtamo, Jarmo ; Wolpin, Brian M. ; Zeleniuch-Jacquotte, Anne ; Fuchs, Charles S. ; Hoover, Robert N. ; Gross, Myron. / Diabetes and risk of pancreatic cancer : A pooled analysis from the pancreatic cancer cohort consortium. In: Cancer Causes and Control. 2013 ; Vol. 24, No. 1. pp. 13-25.
@article{dad5373994e84a87b096c45b270f1702,
title = "Diabetes and risk of pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium",
abstract = "Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 {\%} CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 {\%} CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 {\%} CI: 0.68, 1.52). Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.",
keywords = "Cohort consortium, Diabetes, Pancreatic cancer, Risk factor",
author = "Elena, {Joanne W.} and Emily Steplowski and Kai Yu and Patricia Hartge and Tobias, {Geoffrey S.} and Brotzman, {Michelle J.} and Chanock, {Stephen J.} and Stolzenberg-Solomon, {Rachael Z.} and Arslan, {Alan A.} and Bueno-De-Mesquita, {H. Bas} and Kathy Helzlsouer and Jacobs, {Eric J.} and Andrea Lacroix and Petersen, {Gloria M} and Wei Zheng and Demetrius Albanes and Allen, {Naomi E.} and Laufey Amundadottir and Ying Bao and Heiner Boeing and Boutron-Ruault, {Marie Christine} and Buring, {Julie E.} and Gaziano, {J. Michael} and Giovannucci, {Edward L.} and Duell, {Eric J.} and G{\"o}ran Hallmans and Howard, {Barbara V.} and Hunter, {David J.} and Amy Hutchinson and Jacobs, {Kevin B.} and Charles Kooperberg and Peter Kraft and Mendelsohn, {Julie B.} and Michaud, {Dominique S.} and Domenico Palli and Phillips, {Lawrence S.} and Kim Overvad and Patel, {Alpa V.} and Leah Sansbury and Shu, {Xiao Ou} and Simon, {Michael S.} and Nadia Slimani and Dimitrios Trichopoulos and Kala Visvanathan and Jarmo Virtamo and Wolpin, {Brian M.} and Anne Zeleniuch-Jacquotte and Fuchs, {Charles S.} and Hoover, {Robert N.} and Myron Gross",
year = "2013",
month = "1",
doi = "10.1007/s10552-012-0078-8",
language = "English (US)",
volume = "24",
pages = "13--25",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "1",

}

TY - JOUR

T1 - Diabetes and risk of pancreatic cancer

T2 - A pooled analysis from the pancreatic cancer cohort consortium

AU - Elena, Joanne W.

AU - Steplowski, Emily

AU - Yu, Kai

AU - Hartge, Patricia

AU - Tobias, Geoffrey S.

AU - Brotzman, Michelle J.

AU - Chanock, Stephen J.

AU - Stolzenberg-Solomon, Rachael Z.

AU - Arslan, Alan A.

AU - Bueno-De-Mesquita, H. Bas

AU - Helzlsouer, Kathy

AU - Jacobs, Eric J.

AU - Lacroix, Andrea

AU - Petersen, Gloria M

AU - Zheng, Wei

AU - Albanes, Demetrius

AU - Allen, Naomi E.

AU - Amundadottir, Laufey

AU - Bao, Ying

AU - Boeing, Heiner

AU - Boutron-Ruault, Marie Christine

AU - Buring, Julie E.

AU - Gaziano, J. Michael

AU - Giovannucci, Edward L.

AU - Duell, Eric J.

AU - Hallmans, Göran

AU - Howard, Barbara V.

AU - Hunter, David J.

AU - Hutchinson, Amy

AU - Jacobs, Kevin B.

AU - Kooperberg, Charles

AU - Kraft, Peter

AU - Mendelsohn, Julie B.

AU - Michaud, Dominique S.

AU - Palli, Domenico

AU - Phillips, Lawrence S.

AU - Overvad, Kim

AU - Patel, Alpa V.

AU - Sansbury, Leah

AU - Shu, Xiao Ou

AU - Simon, Michael S.

AU - Slimani, Nadia

AU - Trichopoulos, Dimitrios

AU - Visvanathan, Kala

AU - Virtamo, Jarmo

AU - Wolpin, Brian M.

AU - Zeleniuch-Jacquotte, Anne

AU - Fuchs, Charles S.

AU - Hoover, Robert N.

AU - Gross, Myron

PY - 2013/1

Y1 - 2013/1

N2 - Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.

AB - Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.

KW - Cohort consortium

KW - Diabetes

KW - Pancreatic cancer

KW - Risk factor

UR - http://www.scopus.com/inward/record.url?scp=84871770725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871770725&partnerID=8YFLogxK

U2 - 10.1007/s10552-012-0078-8

DO - 10.1007/s10552-012-0078-8

M3 - Article

C2 - 23112111

AN - SCOPUS:84871770725

VL - 24

SP - 13

EP - 25

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 1

ER -