Diabetes and pancreatic cancer

T. Muniraj, S. T. Chari

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The relationship between diabetes and pancreatic cancer is complex. Diabetes or impaired glucose tolerance is present in more than 2/3rd of pancreatic cancer patients. Epidemiological studies have consistently shown a modest increase in the risk of pancreatic cancer in type 2 diabetes, with an inverse relationship to duration of disease. Additionally, recent studies suggest that anti-diabetic medications may modulate the risk of pancreatic cancer in type 2 diabetes. Subjects >50 years of age with new onset diabetes are at higher risk of having pancreatic cancer. However, to screen new-onset diabetes for pancreatic cancer, additional markers are needed that can distinguish pancreatic cancer-associated diabetes from type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)331-345
Number of pages15
JournalMinerva Gastroenterologica e Dietologica
Volume58
Issue number4
StatePublished - Dec 1 2012

Keywords

  • Diabetes mellitus
  • Glucose intolerance
  • Hyperinsulinemia
  • Pancreatic cancer

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Gastroenterology

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