Dextrose-induced subsynovial connective tissue fibrosis in the rabbit carpal tunnel: A potential model to study carpal tunnel syndrome?

Sangho Oh; Anke M. Ettema; Chunfeng Zhao; Mark E. Zobitz; Lester E. Wold; Kai Nan An; Peter C. Amadio

doi:10.1007/s11552-007-9058-y

Dextrose-induced subsynovial connective tissue fibrosis in the rabbit carpal tunnel: A potential model to study carpal tunnel syndrome?

Sangho Oh, Anke M. Ettema, Chunfeng Zhao, Mark E. Zobitz, Lester E. Wold, Kai Nan An, Peter C. Amadio

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

In this pilot study, hypertonic dextrose solution was used to induce fibrosis of the subsynovial connective tissue (SSCT) and create an animal model of potential use in the study of carpal tunnel syndrome (CTS). The SSCT of the carpal tunnel in 15 New Zealand white rabbits were injected with 0.05 ml of 10% dextrose solution in 1 paw and 0.05 ml of saline in the contralateral paw, to serve as a control. The animals were killed at 1, 2, 4, 8, or 12 weeks. While the saline side showed minimal changes at any time period, the hypertonic dextrose side showed progressive noninflammatory SSCT fibrosis, with vascular proliferation and thickening of collagen bundles. Demyelination of the median nerve developed at 12 weeks after the injection on the dextrose side. These findings are similar to the progression of pathology noted in humans with CTS.

Original language	English (US)
Pages (from-to)	34-40
Number of pages	7
Journal	Hand
Volume	3
Issue number	1
DOIs	https://doi.org/10.1007/s11552-007-9058-y
State	Published - Mar 2008

Keywords

Animal model
Carpal tunnel
Dextrose
Rabbit
Subsynovial connective tissue

ASJC Scopus subject areas

Surgery
Orthopedics and Sports Medicine

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10.1007/s11552-007-9058-y

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title = "Dextrose-induced subsynovial connective tissue fibrosis in the rabbit carpal tunnel: A potential model to study carpal tunnel syndrome?",

abstract = "In this pilot study, hypertonic dextrose solution was used to induce fibrosis of the subsynovial connective tissue (SSCT) and create an animal model of potential use in the study of carpal tunnel syndrome (CTS). The SSCT of the carpal tunnel in 15 New Zealand white rabbits were injected with 0.05 ml of 10% dextrose solution in 1 paw and 0.05 ml of saline in the contralateral paw, to serve as a control. The animals were killed at 1, 2, 4, 8, or 12 weeks. While the saline side showed minimal changes at any time period, the hypertonic dextrose side showed progressive noninflammatory SSCT fibrosis, with vascular proliferation and thickening of collagen bundles. Demyelination of the median nerve developed at 12 weeks after the injection on the dextrose side. These findings are similar to the progression of pathology noted in humans with CTS.",

keywords = "Animal model, Carpal tunnel, Dextrose, Rabbit, Subsynovial connective tissue",

author = "Sangho Oh and Ettema, {Anke M.} and Chunfeng Zhao and Zobitz, {Mark E.} and Wold, {Lester E.} and An, {Kai Nan} and Amadio, {Peter C.}",

note = "Funding Information: Acknowledgement This study was funded by grants from NIH (AR49823) and Mayo Foundation.",

year = "2008",

month = mar,

doi = "10.1007/s11552-007-9058-y",

language = "English (US)",

volume = "3",

pages = "34--40",

journal = "Hand",

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AU - Oh, Sangho

AU - Ettema, Anke M.

AU - Zhao, Chunfeng

AU - Zobitz, Mark E.

AU - Wold, Lester E.

AU - An, Kai Nan

AU - Amadio, Peter C.

N1 - Funding Information: Acknowledgement This study was funded by grants from NIH (AR49823) and Mayo Foundation.

PY - 2008/3

Y1 - 2008/3

N2 - In this pilot study, hypertonic dextrose solution was used to induce fibrosis of the subsynovial connective tissue (SSCT) and create an animal model of potential use in the study of carpal tunnel syndrome (CTS). The SSCT of the carpal tunnel in 15 New Zealand white rabbits were injected with 0.05 ml of 10% dextrose solution in 1 paw and 0.05 ml of saline in the contralateral paw, to serve as a control. The animals were killed at 1, 2, 4, 8, or 12 weeks. While the saline side showed minimal changes at any time period, the hypertonic dextrose side showed progressive noninflammatory SSCT fibrosis, with vascular proliferation and thickening of collagen bundles. Demyelination of the median nerve developed at 12 weeks after the injection on the dextrose side. These findings are similar to the progression of pathology noted in humans with CTS.

AB - In this pilot study, hypertonic dextrose solution was used to induce fibrosis of the subsynovial connective tissue (SSCT) and create an animal model of potential use in the study of carpal tunnel syndrome (CTS). The SSCT of the carpal tunnel in 15 New Zealand white rabbits were injected with 0.05 ml of 10% dextrose solution in 1 paw and 0.05 ml of saline in the contralateral paw, to serve as a control. The animals were killed at 1, 2, 4, 8, or 12 weeks. While the saline side showed minimal changes at any time period, the hypertonic dextrose side showed progressive noninflammatory SSCT fibrosis, with vascular proliferation and thickening of collagen bundles. Demyelination of the median nerve developed at 12 weeks after the injection on the dextrose side. These findings are similar to the progression of pathology noted in humans with CTS.

KW - Animal model

KW - Carpal tunnel

KW - Dextrose

KW - Rabbit

KW - Subsynovial connective tissue

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Dextrose-induced subsynovial connective tissue fibrosis in the rabbit carpal tunnel: A potential model to study carpal tunnel syndrome?

Abstract

Keywords

ASJC Scopus subject areas

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