Dextrose-induced subsynovial connective tissue fibrosis in the rabbit carpal tunnel: A potential model to study carpal tunnel syndrome?

Sangho Oh, Anke M. Ettema, Chunfeng Zhao, Mark E. Zobitz, Lester E. Wold, Kai Nan An, Peter C. Amadio

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

In this pilot study, hypertonic dextrose solution was used to induce fibrosis of the subsynovial connective tissue (SSCT) and create an animal model of potential use in the study of carpal tunnel syndrome (CTS). The SSCT of the carpal tunnel in 15 New Zealand white rabbits were injected with 0.05 ml of 10% dextrose solution in 1 paw and 0.05 ml of saline in the contralateral paw, to serve as a control. The animals were killed at 1, 2, 4, 8, or 12 weeks. While the saline side showed minimal changes at any time period, the hypertonic dextrose side showed progressive noninflammatory SSCT fibrosis, with vascular proliferation and thickening of collagen bundles. Demyelination of the median nerve developed at 12 weeks after the injection on the dextrose side. These findings are similar to the progression of pathology noted in humans with CTS.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalHand
Volume3
Issue number1
DOIs
StatePublished - Mar 1 2008

Keywords

  • Animal model
  • Carpal tunnel
  • Dextrose
  • Rabbit
  • Subsynovial connective tissue

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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