Device-related thrombus following left atrial appendage occlusion

Trevor J. Simard, Benjamin Hibbert, Mohamad A. Alkhouli, Neena S. Abraham, David R. Holmes

Research output: Contribution to journalArticlepeer-review


Thrombus formation on intracardiac devices remains a subject of importance, with rates in the 2-5% range. Device-related thrombus (DRT) following left atrial appendage occlusion (LAAO) is an area of particular concern considering its association with embolic events. DRT continues to present numerous questions, including the optimal definition, incidence, risk factors, monitoring, therapy, and clinical outcomes – all subjects of ongoing assessment. Herein, we discuss these considerations, building upon the relevant historical context and pathophysiologic insights while discussing the future considerations in this rapidly evolving field.

Original languageEnglish (US)
Pages (from-to)224-232
Number of pages9
Issue number3
StatePublished - Jun 2022


  • Amplatzer Amulet
  • Amplatzer Cardiac Plug
  • Watchman
  • device-related thrombus
  • left atrial appendage occlusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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