Developments in sclerostin biology: Regulation of gene expression, mechanisms of action, and physiological functions

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29 Scopus citations

Abstract

The SOST gene, which encodes the protein sclerostin, was identified through genetic linkage analysis of sclerosteosis and van Buchem's disease patients. Sclerostin is a secreted glycoprotein that binds to the low-density lipoprotein receptor-related proteins 4, 5, and 6 to inhibit Wnt signaling. Since the initial discovery of sclerostin, much understanding has been gained into the role of this protein in the regulation of skeletal biology. In this article, we discuss the latest findings in the regulation of SOST expression, sclerostin mechanisms of action, and the potential utility of targeting sclerostin in conditions of low bone mass.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalCurrent osteoporosis reports
Volume12
Issue number1
DOIs
StatePublished - Mar 2014

Keywords

  • LRP
  • Osteocyte
  • Osteoporosis
  • SOST
  • Sclerosteosis
  • Sclerostin
  • Skeleton
  • Wnt

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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