Developmental regulation of neurotensin receptor expression and function in murine neuroblastoma clone N1E-115

Bernadette Cusack, Tiffany Stanton, Elliott Richelson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Murine neuroblastoma cells (clone N1E-115) during their growth from log to late stationary phase, expressed no specific neurotensin binding sites until day 7 in culture. From day 7 to day 20, binding sites increased 6-fold in number/cell and more than 4-fold in sites/mg protein. Neurotensin-mediated cyclic [3H]GMP synthesis was not detected until day 17. For these cells these data show that neurotensin receptor binding and function are regulated with respect to growth cycle and that presence of neurotensin binding sites is not sufficient for receptor function.

Original languageEnglish (US)
Pages (from-to)339-342
Number of pages4
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume206
Issue number4
DOIs
StatePublished - Apr 25 1991

Keywords

  • Cyclic GMP
  • Neurotensin receptors
  • Ontogeny

ASJC Scopus subject areas

  • Pharmacology

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