Development of the summary of findings table for network meta-analysis

Juan José Yepes-Nuñez, Shelly Anne Li, Gordon Guyatt, Susan M. Jack, Jan L. Brozek, Joseph Beyene, M. Hassan Murad, Bram Rochwerg, Lawrence Mbuagbaw, Yuan Zhang, Ivan D. Flórez, Reed A. Siemieniuk, Behnam Sadeghirad, Reem Mustafa, Nancy Santesso, Holger J. Schünemann

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Objectives: The aim of the study was to develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA). Study Design and Setting: We applied a user experience model for data analysis based on four rounds of semistructured interviews. Results: We interviewed 32 stakeholders who conduct or use MA. Four rounds of interviews produced six candidate NMA-SoF tables. Users found a final NMA-SoF table that included the following components highly acceptable: (1) details of the clinical question (PICO), (2) a plot depicting network geometry, (3) relative and absolute effect estimates, (4) certainty of evidence, (5) ranking of treatments, and (6) interpretation of findings. Conclusion: Using stakeholder feedback, we developed a new GRADE NMA-SoF table that includes the relevant components that facilitate understanding NMA findings and health decision-making.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalJournal of Clinical Epidemiology
Volume115
DOIs
StatePublished - Nov 2019

Keywords

  • Certainty of evidence
  • Decision-making
  • GRADE
  • Network meta-analysis
  • Summary of findings
  • Systematic reviews

ASJC Scopus subject areas

  • Epidemiology

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    Yepes-Nuñez, J. J., Li, S. A., Guyatt, G., Jack, S. M., Brozek, J. L., Beyene, J., Murad, M. H., Rochwerg, B., Mbuagbaw, L., Zhang, Y., Flórez, I. D., Siemieniuk, R. A., Sadeghirad, B., Mustafa, R., Santesso, N., & Schünemann, H. J. (2019). Development of the summary of findings table for network meta-analysis. Journal of Clinical Epidemiology, 115, 1-13. https://doi.org/10.1016/j.jclinepi.2019.04.018