Development of the summary of findings table for network meta-analysis

Juan José Yepes-Nuñez; Shelly Anne Li; Gordon Guyatt; Susan M. Jack; Jan L. Brozek; Joseph Beyene; M. Hassan Murad; Bram Rochwerg; Lawrence Mbuagbaw; Yuan Zhang; Ivan D. Flórez; Reed A. Siemieniuk; Behnam Sadeghirad; Reem Mustafa; Nancy Santesso; Holger J. Schünemann

doi:10.1016/j.jclinepi.2019.04.018

Development of the summary of findings table for network meta-analysis

Juan José Yepes-Nuñez, Shelly Anne Li, Gordon Guyatt, Susan M. Jack, Jan L. Brozek, Joseph Beyene, M. Hassan Murad, Bram Rochwerg, Lawrence Mbuagbaw, Yuan Zhang, Ivan D. Flórez, Reed A. Siemieniuk, Behnam Sadeghirad, Reem Mustafa, Nancy Santesso, Holger J. Schünemann

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Objectives: The aim of the study was to develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA). Study Design and Setting: We applied a user experience model for data analysis based on four rounds of semistructured interviews. Results: We interviewed 32 stakeholders who conduct or use MA. Four rounds of interviews produced six candidate NMA-SoF tables. Users found a final NMA-SoF table that included the following components highly acceptable: (1) details of the clinical question (PICO), (2) a plot depicting network geometry, (3) relative and absolute effect estimates, (4) certainty of evidence, (5) ranking of treatments, and (6) interpretation of findings. Conclusion: Using stakeholder feedback, we developed a new GRADE NMA-SoF table that includes the relevant components that facilitate understanding NMA findings and health decision-making.

Original language	English (US)
Pages (from-to)	1-13
Number of pages	13
Journal	Journal of Clinical Epidemiology
Volume	115
DOIs	https://doi.org/10.1016/j.jclinepi.2019.04.018
State	Published - Nov 2019

Keywords

Certainty of evidence
Decision-making
GRADE
Network meta-analysis
Summary of findings
Systematic reviews

ASJC Scopus subject areas

Epidemiology

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10.1016/j.jclinepi.2019.04.018

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Yepes-Nuñez, J. J., Li, S. A., Guyatt, G., Jack, S. M., Brozek, J. L., Beyene, J., Murad, M. H., Rochwerg, B., Mbuagbaw, L., Zhang, Y., Flórez, I. D., Siemieniuk, R. A., Sadeghirad, B., Mustafa, R., Santesso, N., & Schünemann, H. J. (2019). Development of the summary of findings table for network meta-analysis. Journal of Clinical Epidemiology, 115, 1-13. https://doi.org/10.1016/j.jclinepi.2019.04.018

Yepes-Nuñez, JJ, Li, SA, Guyatt, G, Jack, SM, Brozek, JL, Beyene, J, Murad, MH, Rochwerg, B, Mbuagbaw, L, Zhang, Y, Flórez, ID, Siemieniuk, RA, Sadeghirad, B, Mustafa, R, Santesso, N & Schünemann, HJ 2019, 'Development of the summary of findings table for network meta-analysis', Journal of Clinical Epidemiology, vol. 115, pp. 1-13. https://doi.org/10.1016/j.jclinepi.2019.04.018

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abstract = "Objectives: The aim of the study was to develop a Grading of Recommendations, Assessment, Development and Evaluation (GRADE) summary of findings (SoF) table format that displays the critical information from a network meta-analysis (NMA). Study Design and Setting: We applied a user experience model for data analysis based on four rounds of semistructured interviews. Results: We interviewed 32 stakeholders who conduct or use MA. Four rounds of interviews produced six candidate NMA-SoF tables. Users found a final NMA-SoF table that included the following components highly acceptable: (1) details of the clinical question (PICO), (2) a plot depicting network geometry, (3) relative and absolute effect estimates, (4) certainty of evidence, (5) ranking of treatments, and (6) interpretation of findings. Conclusion: Using stakeholder feedback, we developed a new GRADE NMA-SoF table that includes the relevant components that facilitate understanding NMA findings and health decision-making.",

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doi = "10.1016/j.jclinepi.2019.04.018",

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AU - Beyene, Joseph

AU - Murad, M. Hassan

AU - Rochwerg, Bram

AU - Mbuagbaw, Lawrence

AU - Zhang, Yuan

AU - Flórez, Ivan D.

AU - Siemieniuk, Reed A.

AU - Sadeghirad, Behnam

AU - Mustafa, Reem

AU - Santesso, Nancy

AU - Schünemann, Holger J.

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Development of the summary of findings table for network meta-analysis

Abstract

Keywords

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