Development of subsquamous high-grade dysplasia and adenocarcinoma after successful radiofrequency ablation of Barrett's esophagus

Mohammad Titi, Andrew Overhiser, Ozlem Ulusarac, Gary W. Falk, Amitabh Chak, Kenneth Ke Ning Wang, Prateek Sharma

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Patients with Barrett's esophagus are frequently treated with radiofrequency ablation (RFA). Those that undergo this procedure have a low risk of developing subsquamous intestinal metaplasia, and none have been reported to develop subsquamous dysplasia or cancer. We report the development of subsquamous neoplasia in 3 patients who were treated with RFA for Barrett's esophagus (2 developed adenocarcinoma and 1 developed high-grade dysplasia). The identification of these cases indicates the need for continued surveillance following RFA, even after complete eradication of intestinal metaplasia, and caution for widespread use of ablation, especially in patients with low-risk Barrett's esophagus.

Original languageEnglish (US)
JournalGastroenterology
Volume143
Issue number3
DOIs
StatePublished - Sep 2012

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Barrett Esophagus
Adenocarcinoma
Metaplasia
Neoplasms

Keywords

  • Biopsy
  • Cancer Risk
  • Esophageal Adenocarcinoma
  • Therapy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Development of subsquamous high-grade dysplasia and adenocarcinoma after successful radiofrequency ablation of Barrett's esophagus. / Titi, Mohammad; Overhiser, Andrew; Ulusarac, Ozlem; Falk, Gary W.; Chak, Amitabh; Wang, Kenneth Ke Ning; Sharma, Prateek.

In: Gastroenterology, Vol. 143, No. 3, 09.2012.

Research output: Contribution to journalArticle

Titi, Mohammad ; Overhiser, Andrew ; Ulusarac, Ozlem ; Falk, Gary W. ; Chak, Amitabh ; Wang, Kenneth Ke Ning ; Sharma, Prateek. / Development of subsquamous high-grade dysplasia and adenocarcinoma after successful radiofrequency ablation of Barrett's esophagus. In: Gastroenterology. 2012 ; Vol. 143, No. 3.
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