Abstract
This study examined clinical and inflammatory mediator parameters during the development of snuff-induced mucosal lesions. Nineteen smokeless tobacco (ST) users placed moist snuff at designated new placement sites over either a 2-or 7-day period. By day 2, the predominant clinical alteration was an erythematous reaction, and one-third of the subjects demonstrated white striations in combination with erythema or ulceration. By 7 days, 56% of the subjects displayed white striated lesions. Tissue concentrations (pg/mg) of IL-1β were 4.6±1.6 at new placement sites as compared with 0.7±0.4 at control sites (P < 0.05). PGE2 and IL-1α concentrations also were significantly higher (P < 0.05) at new placement sites as compared with control sites (9.4±2.2 vs 4.1±0.7 and 6.2±1.3 vs 3.2±0.7, respectively). In view of the recognized role of PGE2 and IL-1 in immune and inflammatory functions, these mediators may play a role in the pathogenesis of clinical alterations at ST placement sites.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 388-394 |
| Number of pages | 7 |
| Journal | Journal of Oral Pathology and Medicine |
| Volume | 27 |
| Issue number | 8 |
| State | Published - Sep 1998 |
| Externally published | Yes |
Fingerprint
Keywords
- Eicosanoids
- IL-1
- Oral mucosa
- Tobacco, smokeless/adverse effects
ASJC Scopus subject areas
- Cancer Research
- Pathology and Forensic Medicine
- Dentistry(all)
Cite this
Development of smokeless tobacco-induced oral mucosal lesions. / Johnson, Georgia K.; Payne, Jeffrey B.; Fili, James M.; Reinhardt, Richard A.; Organ, Connie C.; Slager, Susan L.
In: Journal of Oral Pathology and Medicine, Vol. 27, No. 8, 09.1998, p. 388-394.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Development of smokeless tobacco-induced oral mucosal lesions
AU - Johnson, Georgia K.
AU - Payne, Jeffrey B.
AU - Fili, James M.
AU - Reinhardt, Richard A.
AU - Organ, Connie C.
AU - Slager, Susan L
PY - 1998/9
Y1 - 1998/9
N2 - This study examined clinical and inflammatory mediator parameters during the development of snuff-induced mucosal lesions. Nineteen smokeless tobacco (ST) users placed moist snuff at designated new placement sites over either a 2-or 7-day period. By day 2, the predominant clinical alteration was an erythematous reaction, and one-third of the subjects demonstrated white striations in combination with erythema or ulceration. By 7 days, 56% of the subjects displayed white striated lesions. Tissue concentrations (pg/mg) of IL-1β were 4.6±1.6 at new placement sites as compared with 0.7±0.4 at control sites (P < 0.05). PGE2 and IL-1α concentrations also were significantly higher (P < 0.05) at new placement sites as compared with control sites (9.4±2.2 vs 4.1±0.7 and 6.2±1.3 vs 3.2±0.7, respectively). In view of the recognized role of PGE2 and IL-1 in immune and inflammatory functions, these mediators may play a role in the pathogenesis of clinical alterations at ST placement sites.
AB - This study examined clinical and inflammatory mediator parameters during the development of snuff-induced mucosal lesions. Nineteen smokeless tobacco (ST) users placed moist snuff at designated new placement sites over either a 2-or 7-day period. By day 2, the predominant clinical alteration was an erythematous reaction, and one-third of the subjects demonstrated white striations in combination with erythema or ulceration. By 7 days, 56% of the subjects displayed white striated lesions. Tissue concentrations (pg/mg) of IL-1β were 4.6±1.6 at new placement sites as compared with 0.7±0.4 at control sites (P < 0.05). PGE2 and IL-1α concentrations also were significantly higher (P < 0.05) at new placement sites as compared with control sites (9.4±2.2 vs 4.1±0.7 and 6.2±1.3 vs 3.2±0.7, respectively). In view of the recognized role of PGE2 and IL-1 in immune and inflammatory functions, these mediators may play a role in the pathogenesis of clinical alterations at ST placement sites.
KW - Eicosanoids
KW - IL-1
KW - Oral mucosa
KW - Tobacco, smokeless/adverse effects
UR - http://www.scopus.com/inward/record.url?scp=0032169287&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032169287&partnerID=8YFLogxK
M3 - Article
C2 - 9736428
AN - SCOPUS:0032169287
VL - 27
SP - 388
EP - 394
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
SN - 0904-2512
IS - 8
ER -