Abstract
This study examined clinical and inflammatory mediator parameters during the development of snuff-induced mucosal lesions. Nineteen smokeless tobacco (ST) users placed moist snuff at designated new placement sites over either a 2-or 7-day period. By day 2, the predominant clinical alteration was an erythematous reaction, and one-third of the subjects demonstrated white striations in combination with erythema or ulceration. By 7 days, 56% of the subjects displayed white striated lesions. Tissue concentrations (pg/mg) of IL-1β were 4.6±1.6 at new placement sites as compared with 0.7±0.4 at control sites (P < 0.05). PGE2 and IL-1α concentrations also were significantly higher (P < 0.05) at new placement sites as compared with control sites (9.4±2.2 vs 4.1±0.7 and 6.2±1.3 vs 3.2±0.7, respectively). In view of the recognized role of PGE2 and IL-1 in immune and inflammatory functions, these mediators may play a role in the pathogenesis of clinical alterations at ST placement sites.
Original language | English (US) |
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Pages (from-to) | 388-394 |
Number of pages | 7 |
Journal | Journal of Oral Pathology and Medicine |
Volume | 27 |
Issue number | 8 |
DOIs | |
State | Published - Sep 1998 |
Keywords
- Eicosanoids
- IL-1
- Oral mucosa
- Tobacco, smokeless/adverse effects
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Oral Surgery
- Otorhinolaryngology
- Cancer Research
- Periodontics