Development of smokeless tobacco-induced oral mucosal lesions

Georgia K. Johnson, Jeffrey B. Payne, James M. Fili, Richard A. Reinhardt, Connie C. Organ, Susan L Slager

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study examined clinical and inflammatory mediator parameters during the development of snuff-induced mucosal lesions. Nineteen smokeless tobacco (ST) users placed moist snuff at designated new placement sites over either a 2-or 7-day period. By day 2, the predominant clinical alteration was an erythematous reaction, and one-third of the subjects demonstrated white striations in combination with erythema or ulceration. By 7 days, 56% of the subjects displayed white striated lesions. Tissue concentrations (pg/mg) of IL-1β were 4.6±1.6 at new placement sites as compared with 0.7±0.4 at control sites (P < 0.05). PGE2 and IL-1α concentrations also were significantly higher (P < 0.05) at new placement sites as compared with control sites (9.4±2.2 vs 4.1±0.7 and 6.2±1.3 vs 3.2±0.7, respectively). In view of the recognized role of PGE2 and IL-1 in immune and inflammatory functions, these mediators may play a role in the pathogenesis of clinical alterations at ST placement sites.

Original languageEnglish (US)
Pages (from-to)388-394
Number of pages7
JournalJournal of Oral Pathology and Medicine
Volume27
Issue number8
StatePublished - Sep 1998
Externally publishedYes

Fingerprint

Smokeless Tobacco
Interleukin-1
Dinoprostone
Erythema

Keywords

  • Eicosanoids
  • IL-1
  • Oral mucosa
  • Tobacco, smokeless/adverse effects

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Johnson, G. K., Payne, J. B., Fili, J. M., Reinhardt, R. A., Organ, C. C., & Slager, S. L. (1998). Development of smokeless tobacco-induced oral mucosal lesions. Journal of Oral Pathology and Medicine, 27(8), 388-394.

Development of smokeless tobacco-induced oral mucosal lesions. / Johnson, Georgia K.; Payne, Jeffrey B.; Fili, James M.; Reinhardt, Richard A.; Organ, Connie C.; Slager, Susan L.

In: Journal of Oral Pathology and Medicine, Vol. 27, No. 8, 09.1998, p. 388-394.

Research output: Contribution to journalArticle

Johnson, GK, Payne, JB, Fili, JM, Reinhardt, RA, Organ, CC & Slager, SL 1998, 'Development of smokeless tobacco-induced oral mucosal lesions', Journal of Oral Pathology and Medicine, vol. 27, no. 8, pp. 388-394.
Johnson GK, Payne JB, Fili JM, Reinhardt RA, Organ CC, Slager SL. Development of smokeless tobacco-induced oral mucosal lesions. Journal of Oral Pathology and Medicine. 1998 Sep;27(8):388-394.
Johnson, Georgia K. ; Payne, Jeffrey B. ; Fili, James M. ; Reinhardt, Richard A. ; Organ, Connie C. ; Slager, Susan L. / Development of smokeless tobacco-induced oral mucosal lesions. In: Journal of Oral Pathology and Medicine. 1998 ; Vol. 27, No. 8. pp. 388-394.
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