Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging

Michael K. O'Connor, Carrie B Hruska, Amanda Weinmann, Armando Manduca, Deborah Rhodes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Background: Molecular breast imaging (MBI) is a novel breast imaging technique that uses Cadmium Zinc Telluride (CZT) gamma cameras to detect the uptake of Tc-99m sestamibi in breast tumors. Current techniques employ an administered dose of 20-30 mCi Tc-99m, delivering an effective dose of 6.5-10 mSv to the body. This is ∼5-10 times that of mammography. The goal of this study was to reduce the radiation dose by a factor of 5-10, while maintaining image quality. Methods: A total of 4 dose reduction schemes were evaluated - a) optimized collimation, b) improved utilization of the energy spectrum below the photopeak, c) adaptive geometric mean algorithm developed for combination of images from opposing detectors, and d) non local means filtering (NLMF) for noise reduction and image enhancement. Validation of the various schemes was performed using a breast phantom containing a variety of tumors and containing activity matched to that observed in clinical studies. Results: Development of tungsten collimators with holes matched to the CZT pixels yielded a 2.1-2.9 gain in system sensitivity. Improved utilization of the energy spectra yielded a 1.5-2.0 gain in sensitivity. Development of a modified geometric mean algorithm yielded a 1.4 reduction in image noise, while retaining contrast. Images of the breast phantom demonstrated that a factor of 5 reduction in dose was achieved. Additional refinements to the NLMF should enable an additional factor of 2 reduction in dose. Conclusion: Significant dose reduction in MBI to levels comparable to mammography can be achieved while maintaining image quality.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume7806
DOIs
StatePublished - 2010
EventPenetrating Radiation Systems and Applications XI - San Diego, CA, United States
Duration: Aug 2 2010Aug 5 2010

Other

OtherPenetrating Radiation Systems and Applications XI
CountryUnited States
CitySan Diego, CA
Period8/2/108/5/10

Fingerprint

zinc tellurides
cadmium tellurides
Zinc
breast
Cadmium
Dosimetry
Dose
Radiation
Imaging
Detector
Detectors
Imaging techniques
dosage
detectors
radiation
Mammography
Image quality
Tumors
Geometric mean
Phantom

Keywords

  • Collimation
  • Energy Spectrum
  • Filtering
  • Molecular Breast Imaging
  • Noise Reduction
  • Radiation Dose

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

O'Connor, M. K., Hruska, C. B., Weinmann, A., Manduca, A., & Rhodes, D. (2010). Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 7806). [780603] https://doi.org/10.1117/12.864649

Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging. / O'Connor, Michael K.; Hruska, Carrie B; Weinmann, Amanda; Manduca, Armando; Rhodes, Deborah.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7806 2010. 780603.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

O'Connor, MK, Hruska, CB, Weinmann, A, Manduca, A & Rhodes, D 2010, Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 7806, 780603, Penetrating Radiation Systems and Applications XI, San Diego, CA, United States, 8/2/10. https://doi.org/10.1117/12.864649
O'Connor MK, Hruska CB, Weinmann A, Manduca A, Rhodes D. Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7806. 2010. 780603 https://doi.org/10.1117/12.864649
O'Connor, Michael K. ; Hruska, Carrie B ; Weinmann, Amanda ; Manduca, Armando ; Rhodes, Deborah. / Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7806 2010.
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