Development of electrically conductive oligo(polyethylene glycol) fumarate-polypyrrole hydrogels for nerve regeneration

M. Brett Runge, Mahrokh Dadsetan, Jonas Baltrusaitis, Terry Ruesink, Lichun Lu, Anthony John Windebank, Michael J Yaszemski

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Electrically conductive hydrogel composites consisting of oligo(polyethylene glycol) fumarate (OPF) and polypyrrole (PPy) were developed for applications in nerve regeneration. OPF-PPy scaffolds were synthesized using three different anions: naphthalene-2-sulfonic acid sodium salt (NSA), dodecylbenzenesulfonic acid sodium salt (DBSA), and dioctyl sulfosuccinate sodium salt (DOSS). Scaffolds were characterized by ATR-FTIR, XPS, AFM, dynamic mechanical analysis, electrical resistivity measurements, and swelling experiments. OPF-PPy scaffolds were shown to consist of up to 25 mol % polypyrrole with a compressive modulus ranging from 265 to 323 kPa and a sheet resistance ranging from 6 to 30 × 103 Ohms/square. In vitro studies using PC12 cells showed OPF-PPy materials had no cytotoxicity and PC12 cells showed distinctly better cell attachment and an increase in the percent of neurite bearing cells on OPF-PPy materials compared to OPF. The neurite lengths of PC12 cells were significantly higher on OPF-PPyNSA and OPF-PPyDBSA. These results show that electrically conductive OPF-PPy hydrogels are promising candidates for future applications in nerve regeneration.

Original languageEnglish (US)
Pages (from-to)2845-2853
Number of pages9
JournalBiomacromolecules
Volume11
Issue number11
DOIs
StatePublished - Nov 8 2010

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Fumarates
Nerve Regeneration
Hydrogels
Polypyrroles
Polyethylene glycols
PC12 Cells
Scaffolds
Sodium
Neurites
Salts
Bearings (structural)
Dioctyl Sulfosuccinic Acid
Acids
Hydrogel
Sheet resistance
Dynamic mechanical analysis
Fourier Transform Infrared Spectroscopy
Naphthalene
Cytotoxicity
polypyrrole

ASJC Scopus subject areas

  • Bioengineering
  • Materials Chemistry
  • Polymers and Plastics
  • Biomaterials
  • Medicine(all)

Cite this

Development of electrically conductive oligo(polyethylene glycol) fumarate-polypyrrole hydrogels for nerve regeneration. / Runge, M. Brett; Dadsetan, Mahrokh; Baltrusaitis, Jonas; Ruesink, Terry; Lu, Lichun; Windebank, Anthony John; Yaszemski, Michael J.

In: Biomacromolecules, Vol. 11, No. 11, 08.11.2010, p. 2845-2853.

Research output: Contribution to journalArticle

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