Development of chronic colitis is dependent on the cytokine MIF

Ype P. De Jong, Ana C. Abadia-Molina, Abhay R. Satoskar, Kareem Clarke, Svend T. Rietdijk, William A. Faubion, Emiko Mizoguchi, Christine N. Metz, Mazen Al Sahli, Tessa Ten Hove, Andrew C. Keates, Jodi B. Lubetsky, Richard J. Farrell, Pierre Michetti, Sander J. Van Deventer, Elias Lolis, John R. David, Atul K. Bhan, Cox Terhorst

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Abstract

The cytokine macrophage-migration inhibitory factor (MIF) is secreted by a number of cell types upon induction by lipopolysaccharide (LPS). Because colitis is dependent on interplay between the mucosal immune system and intestinal bacteria, we investigated the role of MIF in experimental colitis. MIF-deficient mice failed to develop disease, but reconstitution of MIF-deficient mice with wild-type innate immune cells restored colitis. In addition, established colitis could be treated with anti-MIF immunoglobulins. Thus, murine colitis is dependent on continuous MIF production by the innate immune system. Because we found increased plasma MIF concentrations in patients with Crohn's disease, these data suggested that MIF is a new target for intervention in Crohn's disease.

Original languageEnglish (US)
Pages (from-to)1061-1066
Number of pages6
JournalNature immunology
Volume2
Issue number11
DOIs
StatePublished - Nov 28 2001

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

De Jong, Y. P., Abadia-Molina, A. C., Satoskar, A. R., Clarke, K., Rietdijk, S. T., Faubion, W. A., Mizoguchi, E., Metz, C. N., Sahli, M. A., Ten Hove, T., Keates, A. C., Lubetsky, J. B., Farrell, R. J., Michetti, P., Van Deventer, S. J., Lolis, E., David, J. R., Bhan, A. K., & Terhorst, C. (2001). Development of chronic colitis is dependent on the cytokine MIF. Nature immunology, 2(11), 1061-1066. https://doi.org/10.1038/ni720