Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation

Alexandra M. Dulude, Joyce D'Souza, Nedra Harrison, Ramesk K Ramanathan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Breast cancer at age 21 is rare, even in individuals who have a genetic predisposition. These early diagnoses are usually the result of a hereditary cancer syndrome. Other contributing factors, such as chemotherapy and radiation for previous malignancies, can also increase the risk of secondary malignancies, including breast cancer. Here we present one of the youngest cases of breast cancer reported in the literature: a 21-year-old Wilms' tumor survivor (diagnosed at age 6), who was found to have a familial BRCA1 mutation and was diagnosed with ductal carcinoma in situ at age 21.

Original languageEnglish (US)
Pages (from-to)268-269
Number of pages2
JournalClinical Breast Cancer
Volume11
Issue number4
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Wilms Tumor
Breast Neoplasms
Mutation
Hereditary Neoplastic Syndromes
Carcinoma, Intraductal, Noninfiltrating
Genetic Predisposition to Disease
Early Diagnosis
Neoplasms
Radiation
Drug Therapy

Keywords

  • BRCA1
  • Breast cancer
  • Radiation therapy
  • Wilms' tumor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation. / Dulude, Alexandra M.; D'Souza, Joyce; Harrison, Nedra; Ramanathan, Ramesk K.

In: Clinical Breast Cancer, Vol. 11, No. 4, 2011, p. 268-269.

Research output: Contribution to journalArticle

Dulude, Alexandra M. ; D'Souza, Joyce ; Harrison, Nedra ; Ramanathan, Ramesk K. / Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation. In: Clinical Breast Cancer. 2011 ; Vol. 11, No. 4. pp. 268-269.
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