Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation

Alexandra M. Dulude, Joyce D'Souza, Nedra Harrison, Ramesh K. Ramanathan

Research output: Contribution to journalArticle

2 Scopus citations


Breast cancer at age 21 is rare, even in individuals who have a genetic predisposition. These early diagnoses are usually the result of a hereditary cancer syndrome. Other contributing factors, such as chemotherapy and radiation for previous malignancies, can also increase the risk of secondary malignancies, including breast cancer. Here we present one of the youngest cases of breast cancer reported in the literature: a 21-year-old Wilms' tumor survivor (diagnosed at age 6), who was found to have a familial BRCA1 mutation and was diagnosed with ductal carcinoma in situ at age 21.

Original languageEnglish (US)
Pages (from-to)268-269
Number of pages2
JournalClinical breast cancer
Issue number4
StatePublished - Aug 2011



  • BRCA1
  • Breast cancer
  • Radiation therapy
  • Wilms' tumor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this