TY - JOUR
T1 - Development of breast cancer in a 21-year-old childhood Wilms' tumor survivor with a BRCA1 2634delC mutation
AU - Dulude, Alexandra M.
AU - D'Souza, Joyce
AU - Harrison, Nedra
AU - Ramanathan, Ramesh K.
PY - 2011/8
Y1 - 2011/8
N2 - Breast cancer at age 21 is rare, even in individuals who have a genetic predisposition. These early diagnoses are usually the result of a hereditary cancer syndrome. Other contributing factors, such as chemotherapy and radiation for previous malignancies, can also increase the risk of secondary malignancies, including breast cancer. Here we present one of the youngest cases of breast cancer reported in the literature: a 21-year-old Wilms' tumor survivor (diagnosed at age 6), who was found to have a familial BRCA1 mutation and was diagnosed with ductal carcinoma in situ at age 21.
AB - Breast cancer at age 21 is rare, even in individuals who have a genetic predisposition. These early diagnoses are usually the result of a hereditary cancer syndrome. Other contributing factors, such as chemotherapy and radiation for previous malignancies, can also increase the risk of secondary malignancies, including breast cancer. Here we present one of the youngest cases of breast cancer reported in the literature: a 21-year-old Wilms' tumor survivor (diagnosed at age 6), who was found to have a familial BRCA1 mutation and was diagnosed with ductal carcinoma in situ at age 21.
KW - BRCA1
KW - Breast cancer
KW - Radiation therapy
KW - Wilms' tumor
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U2 - 10.1016/j.clbc.2010.11.001
DO - 10.1016/j.clbc.2010.11.001
M3 - Article
C2 - 21729660
AN - SCOPUS:80052702967
SN - 1526-8209
VL - 11
SP - 268
EP - 269
JO - Clinical Breast Cancer
JF - Clinical Breast Cancer
IS - 4
ER -