Development of an intravenous bile acid tolerance test: plasma disappearance of cholylglycine in health

M. G. Korman, Nicholas F La Russo, N. E. Hoffman, A. F. Hofmann

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

To develop an intravenous bile acid tolerance test that might be useful for detecting impaired liver function or liver injury, the plasma disappearance of intravenously injected cholylglycine was characterized in healthy man by a radioimmunoassay, specific for conjugates of colic acid, on serial samples of venous blood. Cholylglycine disappearance was rapid (mean half life ± S.E. = 2.6 ± 0.1 minutes) and of first order kinetics; the rate of disappearance was independent of dose between 2 and 15 μmoles per kilogram of body weight. A dose of 5 μ moles per kilogram was selected as an optimal dose, and its clearance was defined in 45 healthy subjects. After intravenous injection of this dose, conjugates of cholic acid increased 10 fold, but in all subjects the concentration of these bile acids had returned to 1 μM (the upper limit of normal, fasting state) by 10 minutes. No side effects were observed.

Original languageEnglish (US)
Pages (from-to)1205-1209
Number of pages5
JournalNew England Journal of Medicine
Volume292
Issue number23
StatePublished - 1975

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Glycocholic Acid
Bile Acids and Salts
Cholic Acid
Colic
Liver
Health
Intravenous Injections
Radioimmunoassay
Half-Life
Fasting
Healthy Volunteers
Body Weight
Acids
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

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Development of an intravenous bile acid tolerance test : plasma disappearance of cholylglycine in health. / Korman, M. G.; La Russo, Nicholas F; Hoffman, N. E.; Hofmann, A. F.

In: New England Journal of Medicine, Vol. 292, No. 23, 1975, p. 1205-1209.

Research output: Contribution to journalArticle

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