Development of a Vessel-Mimicking Material for use in Anatomically Realistic Doppler Flow Phantoms

Deirdre M. King; Carmel M. Moran; John D. McNamara; Andrew J. Fagan; Jacinta E. Browne

doi:10.1016/j.ultrasmedbio.2011.02.012

Development of a Vessel-Mimicking Material for use in Anatomically Realistic Doppler Flow Phantoms

Deirdre M. King, Carmel M. Moran, John D. McNamara, Andrew J. Fagan, Jacinta E. Browne

Radiology

Research output: Contribution to journal › Article › peer-review

Abstract

Polyvinyl alcohol cryogel (PVA-C) is presented as a vessel-mimicking material for use in anatomically realistic Doppler flow phantoms. Three different batches of 10% wt PVA-C containing (i) PVA-C alone, (ii) PVA-C with antibacterial agent and (iii) PVA-C with silicon carbide particles were produced, each with 1-6 freeze-thaw cycles. The resulting PVA-C samples were characterized acoustically (over a range 2.65 to 10.5 MHz) and mechanically to determine the optimum mixture and preparation for mimicking the properties of healthy and diseased arteries found in vivo. This optimum mix was reached with the PVA-C with antibacterial agent sample, prepared after two freeze/thaw cycles, which achieved a speed of sound of 1538 ± 5 m s^-1 and a Young's elastic modulus of 79 ± 11 kPa. This material was used to make a range of anatomically realistic flow phantoms with varying degrees of stenoses, and subsequent flow experiments revealed that higher degrees of stenoses and higher velocities could be achieved without phantom rupturing compared with a phantom containing conventional wall-less vessels. (E-mail:jacinta.browne@dit.ie).

Original language	English (US)
Pages (from-to)	813-826
Number of pages	14
Journal	Ultrasound in Medicine and Biology
Volume	37
Issue number	5
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2011.02.012
State	Published - May 2011

Keywords

Acoustic and mechanical characterization
Anatomically realistic flow phantom
Polyvinyl alcohol cryogel
Ultrasound phantom
Vessel mimic

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Biophysics
Acoustics and Ultrasonics

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10.1016/j.ultrasmedbio.2011.02.012

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title = "Development of a Vessel-Mimicking Material for use in Anatomically Realistic Doppler Flow Phantoms",

abstract = "Polyvinyl alcohol cryogel (PVA-C) is presented as a vessel-mimicking material for use in anatomically realistic Doppler flow phantoms. Three different batches of 10% wt PVA-C containing (i) PVA-C alone, (ii) PVA-C with antibacterial agent and (iii) PVA-C with silicon carbide particles were produced, each with 1-6 freeze-thaw cycles. The resulting PVA-C samples were characterized acoustically (over a range 2.65 to 10.5 MHz) and mechanically to determine the optimum mixture and preparation for mimicking the properties of healthy and diseased arteries found in vivo. This optimum mix was reached with the PVA-C with antibacterial agent sample, prepared after two freeze/thaw cycles, which achieved a speed of sound of 1538 ± 5 m s-1 and a Young's elastic modulus of 79 ± 11 kPa. This material was used to make a range of anatomically realistic flow phantoms with varying degrees of stenoses, and subsequent flow experiments revealed that higher degrees of stenoses and higher velocities could be achieved without phantom rupturing compared with a phantom containing conventional wall-less vessels. (E-mail:jacinta.browne@dit.ie).",

keywords = "Acoustic and mechanical characterization, Anatomically realistic flow phantom, Polyvinyl alcohol cryogel, Ultrasound phantom, Vessel mimic",

author = "King, {Deirdre M.} and Moran, {Carmel M.} and McNamara, {John D.} and Fagan, {Andrew J.} and Browne, {Jacinta E.}",

note = "Funding Information: The authors wish to thank Peter Hoskins and James Blake (University of Edinburgh) for the use of the SAM system and technical assistance. This work was supported by the Technological Sector Research Strand 1 Scheme, HEA and the TERs 2005 and CABS 2007 Schemes, Research Support Unit, Dublin Institute of Technology . C.M.M. would like to acknowledge funding from the British Heart Foundation ( PG/07/107 ) and the advice and use of physical test facilities provided by Dr. Thomas Alshuth and Peter Erren of the Deutsches Institut f{\"u}r Kautschuktechnologie e.V. (Hannover).",

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AU - Fagan, Andrew J.

AU - Browne, Jacinta E.

N1 - Funding Information: The authors wish to thank Peter Hoskins and James Blake (University of Edinburgh) for the use of the SAM system and technical assistance. This work was supported by the Technological Sector Research Strand 1 Scheme, HEA and the TERs 2005 and CABS 2007 Schemes, Research Support Unit, Dublin Institute of Technology . C.M.M. would like to acknowledge funding from the British Heart Foundation ( PG/07/107 ) and the advice and use of physical test facilities provided by Dr. Thomas Alshuth and Peter Erren of the Deutsches Institut für Kautschuktechnologie e.V. (Hannover).

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N2 - Polyvinyl alcohol cryogel (PVA-C) is presented as a vessel-mimicking material for use in anatomically realistic Doppler flow phantoms. Three different batches of 10% wt PVA-C containing (i) PVA-C alone, (ii) PVA-C with antibacterial agent and (iii) PVA-C with silicon carbide particles were produced, each with 1-6 freeze-thaw cycles. The resulting PVA-C samples were characterized acoustically (over a range 2.65 to 10.5 MHz) and mechanically to determine the optimum mixture and preparation for mimicking the properties of healthy and diseased arteries found in vivo. This optimum mix was reached with the PVA-C with antibacterial agent sample, prepared after two freeze/thaw cycles, which achieved a speed of sound of 1538 ± 5 m s-1 and a Young's elastic modulus of 79 ± 11 kPa. This material was used to make a range of anatomically realistic flow phantoms with varying degrees of stenoses, and subsequent flow experiments revealed that higher degrees of stenoses and higher velocities could be achieved without phantom rupturing compared with a phantom containing conventional wall-less vessels. (E-mail:jacinta.browne@dit.ie).

AB - Polyvinyl alcohol cryogel (PVA-C) is presented as a vessel-mimicking material for use in anatomically realistic Doppler flow phantoms. Three different batches of 10% wt PVA-C containing (i) PVA-C alone, (ii) PVA-C with antibacterial agent and (iii) PVA-C with silicon carbide particles were produced, each with 1-6 freeze-thaw cycles. The resulting PVA-C samples were characterized acoustically (over a range 2.65 to 10.5 MHz) and mechanically to determine the optimum mixture and preparation for mimicking the properties of healthy and diseased arteries found in vivo. This optimum mix was reached with the PVA-C with antibacterial agent sample, prepared after two freeze/thaw cycles, which achieved a speed of sound of 1538 ± 5 m s-1 and a Young's elastic modulus of 79 ± 11 kPa. This material was used to make a range of anatomically realistic flow phantoms with varying degrees of stenoses, and subsequent flow experiments revealed that higher degrees of stenoses and higher velocities could be achieved without phantom rupturing compared with a phantom containing conventional wall-less vessels. (E-mail:jacinta.browne@dit.ie).

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Development of a Vessel-Mimicking Material for use in Anatomically Realistic Doppler Flow Phantoms

Abstract

Keywords

ASJC Scopus subject areas

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