Development of a test to measure gastric accommodation in humans

Sjoerd D. Kuiken, Melvin Samsom, Michael Camilleri, Brian P. Mullan, Duane D. Burton, Louis J. Kost, Timothy J. Hardyman, Benjamin Brinkmann, Michael K. O'Connor

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Postprandial symptoms of bloating, distension, early satiety, and nausea are associated with impaired postprandial gastric accommodation, which is detectable by means of an intragastric, barostatically controlled balloon in the proximal stomach and by ultrasound in the distal stomach. Our aim was to develop a noninvasive method to measure the entire gastric accommodation reflex. In 10 healthy volunteers, we used single photon emission computed tomography (SPECT) to measure fasting and postprandial gastric volumes. This method involved intravenous injection of 99mTc pertechnetate and gastric reconstruction of tomographic images with Analyze software. SPECT-Analyze imaging detects the postprandial gastric accommodation reflex in vivo. Mean fasting gastric volume was 182 ± 11 (SE) ml and mean postprandial volume was 690 ± 32 ml (P < 0.001). Both proximal and distal segments of stomach showed a two- to almost fourfold difference in volumes postprandially. Intraobserver coefficients of variation in estimated fasting and postprandial volumes were 9 and 8%; interobserver variations were 13 and 12%, respectively. SPECT- Analyze noninvasively measures postprandial gastric (total, proximal, and distal) accommodation in humans. This method appears promising to compare the accommodation response in health and disease and to perform mechanistic studies of the accommodation response.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume277
Issue number6 40-6
StatePublished - Dec 1999

Fingerprint

Stomach
Single-Photon Emission-Computed Tomography
Fasting
Observer Variation
Reflex
Sodium Pertechnetate Tc 99m
Computer-Assisted Image Processing
Intravenous Injections
Nausea
Healthy Volunteers
Software
Health

Keywords

  • Analyze software
  • Motility
  • Single photon emission computer tomography
  • Stomach

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology
  • Physiology (medical)

Cite this

Kuiken, S. D., Samsom, M., Camilleri, M., Mullan, B. P., Burton, D. D., Kost, L. J., ... O'Connor, M. K. (1999). Development of a test to measure gastric accommodation in humans. American Journal of Physiology - Gastrointestinal and Liver Physiology, 277(6 40-6).

Development of a test to measure gastric accommodation in humans. / Kuiken, Sjoerd D.; Samsom, Melvin; Camilleri, Michael; Mullan, Brian P.; Burton, Duane D.; Kost, Louis J.; Hardyman, Timothy J.; Brinkmann, Benjamin; O'Connor, Michael K.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 277, No. 6 40-6, 12.1999.

Research output: Contribution to journalArticle

Kuiken, SD, Samsom, M, Camilleri, M, Mullan, BP, Burton, DD, Kost, LJ, Hardyman, TJ, Brinkmann, B & O'Connor, MK 1999, 'Development of a test to measure gastric accommodation in humans', American Journal of Physiology - Gastrointestinal and Liver Physiology, vol. 277, no. 6 40-6.
Kuiken, Sjoerd D. ; Samsom, Melvin ; Camilleri, Michael ; Mullan, Brian P. ; Burton, Duane D. ; Kost, Louis J. ; Hardyman, Timothy J. ; Brinkmann, Benjamin ; O'Connor, Michael K. / Development of a test to measure gastric accommodation in humans. In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 1999 ; Vol. 277, No. 6 40-6.
@article{54ca7ceb717240358e768fd957e8888b,
title = "Development of a test to measure gastric accommodation in humans",
abstract = "Postprandial symptoms of bloating, distension, early satiety, and nausea are associated with impaired postprandial gastric accommodation, which is detectable by means of an intragastric, barostatically controlled balloon in the proximal stomach and by ultrasound in the distal stomach. Our aim was to develop a noninvasive method to measure the entire gastric accommodation reflex. In 10 healthy volunteers, we used single photon emission computed tomography (SPECT) to measure fasting and postprandial gastric volumes. This method involved intravenous injection of 99mTc pertechnetate and gastric reconstruction of tomographic images with Analyze software. SPECT-Analyze imaging detects the postprandial gastric accommodation reflex in vivo. Mean fasting gastric volume was 182 ± 11 (SE) ml and mean postprandial volume was 690 ± 32 ml (P < 0.001). Both proximal and distal segments of stomach showed a two- to almost fourfold difference in volumes postprandially. Intraobserver coefficients of variation in estimated fasting and postprandial volumes were 9 and 8{\%}; interobserver variations were 13 and 12{\%}, respectively. SPECT- Analyze noninvasively measures postprandial gastric (total, proximal, and distal) accommodation in humans. This method appears promising to compare the accommodation response in health and disease and to perform mechanistic studies of the accommodation response.",
keywords = "Analyze software, Motility, Single photon emission computer tomography, Stomach",
author = "Kuiken, {Sjoerd D.} and Melvin Samsom and Michael Camilleri and Mullan, {Brian P.} and Burton, {Duane D.} and Kost, {Louis J.} and Hardyman, {Timothy J.} and Benjamin Brinkmann and O'Connor, {Michael K.}",
year = "1999",
month = "12",
language = "English (US)",
volume = "277",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "6 40-6",

}

TY - JOUR

T1 - Development of a test to measure gastric accommodation in humans

AU - Kuiken, Sjoerd D.

AU - Samsom, Melvin

AU - Camilleri, Michael

AU - Mullan, Brian P.

AU - Burton, Duane D.

AU - Kost, Louis J.

AU - Hardyman, Timothy J.

AU - Brinkmann, Benjamin

AU - O'Connor, Michael K.

PY - 1999/12

Y1 - 1999/12

N2 - Postprandial symptoms of bloating, distension, early satiety, and nausea are associated with impaired postprandial gastric accommodation, which is detectable by means of an intragastric, barostatically controlled balloon in the proximal stomach and by ultrasound in the distal stomach. Our aim was to develop a noninvasive method to measure the entire gastric accommodation reflex. In 10 healthy volunteers, we used single photon emission computed tomography (SPECT) to measure fasting and postprandial gastric volumes. This method involved intravenous injection of 99mTc pertechnetate and gastric reconstruction of tomographic images with Analyze software. SPECT-Analyze imaging detects the postprandial gastric accommodation reflex in vivo. Mean fasting gastric volume was 182 ± 11 (SE) ml and mean postprandial volume was 690 ± 32 ml (P < 0.001). Both proximal and distal segments of stomach showed a two- to almost fourfold difference in volumes postprandially. Intraobserver coefficients of variation in estimated fasting and postprandial volumes were 9 and 8%; interobserver variations were 13 and 12%, respectively. SPECT- Analyze noninvasively measures postprandial gastric (total, proximal, and distal) accommodation in humans. This method appears promising to compare the accommodation response in health and disease and to perform mechanistic studies of the accommodation response.

AB - Postprandial symptoms of bloating, distension, early satiety, and nausea are associated with impaired postprandial gastric accommodation, which is detectable by means of an intragastric, barostatically controlled balloon in the proximal stomach and by ultrasound in the distal stomach. Our aim was to develop a noninvasive method to measure the entire gastric accommodation reflex. In 10 healthy volunteers, we used single photon emission computed tomography (SPECT) to measure fasting and postprandial gastric volumes. This method involved intravenous injection of 99mTc pertechnetate and gastric reconstruction of tomographic images with Analyze software. SPECT-Analyze imaging detects the postprandial gastric accommodation reflex in vivo. Mean fasting gastric volume was 182 ± 11 (SE) ml and mean postprandial volume was 690 ± 32 ml (P < 0.001). Both proximal and distal segments of stomach showed a two- to almost fourfold difference in volumes postprandially. Intraobserver coefficients of variation in estimated fasting and postprandial volumes were 9 and 8%; interobserver variations were 13 and 12%, respectively. SPECT- Analyze noninvasively measures postprandial gastric (total, proximal, and distal) accommodation in humans. This method appears promising to compare the accommodation response in health and disease and to perform mechanistic studies of the accommodation response.

KW - Analyze software

KW - Motility

KW - Single photon emission computer tomography

KW - Stomach

UR - http://www.scopus.com/inward/record.url?scp=0033369383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033369383&partnerID=8YFLogxK

M3 - Article

C2 - 10600819

AN - SCOPUS:0033369383

VL - 277

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 6 40-6

ER -