Development of a minigenome system for Andes virus, a New World hantavirus

Kyle S. Brown, Hideki Ebihara, Heinz Feldmann

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The development of reverse genetics systems for negative-stranded RNA viruses is a rapidly evolving field that has greatly advanced the study of the many different aspects of the viral life cycle. Andes virus (ANDV) is a highly pathogenic hantavirus found in South America that causes hantavirus pulmonary syndrome but to date remains poorly characterized due to the lack of a reverse genetics system for genetic manipulation. Here, we describe the first successful minigenome system for a New World hantavirus, as well as many of the obstacles that still exist in the development of such a system.

Original languageEnglish (US)
Pages (from-to)2227-2233
Number of pages7
JournalArchives of Virology
Volume157
Issue number11
DOIs
StatePublished - Nov 2012

ASJC Scopus subject areas

  • Virology

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