Development of a microfluidic drug delivery neural prosthesis using a wide bandgap semiconductor waveguide structure

Mona R. Safadi, Gregory Auner, Raymond Iezzi, Pat McAllister, Gary Abrams

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We have developed a microfluidic retinal prosthesis, using wide bandgap optical wavelength semiconductor thin film waveguides, to facilitate spatial and quantitative photactivation of "caged" neurotransmitter to microfluidic channels. Novel waveguide materials and micromachining technology are necessary to fabricate 360 nanometer capable waveguides for the microfluidic device. Single crystal wide bandgap semiconductor thin films are grown on sapphire by plasma source molecular beam epitaxy (PSMBE). 248 nanometer KrF Excimer laser micromachining technology is employed to micro-fabricate wave-guiding channels and microfluidic structures. A waveguide that allows for spatial and temporal drug delivery within the retina was fabricated. In addition, there is a need for a waveguide structure that may be used in physiological drug delivery systems. A device that may deliver ultraviolet light in precise intensities and to selective areas of a microfluidic implant without direct ultraviolet exposure to the biological cells is needed in retinal and cortical implants. Results of a prototype microfluidic waveguide system will be presented.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsH. Becker, P. Woias
Pages330-339
Number of pages10
Volume4982
DOIs
StatePublished - 2003
Externally publishedYes
EventMicrofluidics, BioMEMS, and Medical Microsystems - San Jose, CA, United States
Duration: Jan 27 2003Jan 29 2003

Other

OtherMicrofluidics, BioMEMS, and Medical Microsystems
CountryUnited States
CitySan Jose, CA
Period1/27/031/29/03

Fingerprint

Neural prostheses
Drug delivery
Microfluidics
delivery
drugs
Energy gap
Waveguides
Semiconductor materials
waveguides
Micromachining
neurotransmitters
Thin films
laser machining
Plasma sources
retina
microfluidic devices
Optical band gaps
Excimer lasers
micromachining
thin films

Keywords

  • Drug-Delivery
  • Excimer laser
  • Mi cromachining
  • Microfluidic
  • Semiconductor
  • Thin-film
  • Ultraviolet
  • Waveguide

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Safadi, M. R., Auner, G., Iezzi, R., McAllister, P., & Abrams, G. (2003). Development of a microfluidic drug delivery neural prosthesis using a wide bandgap semiconductor waveguide structure. In H. Becker, & P. Woias (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4982, pp. 330-339) https://doi.org/10.1117/12.478158

Development of a microfluidic drug delivery neural prosthesis using a wide bandgap semiconductor waveguide structure. / Safadi, Mona R.; Auner, Gregory; Iezzi, Raymond; McAllister, Pat; Abrams, Gary.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / H. Becker; P. Woias. Vol. 4982 2003. p. 330-339.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Safadi, MR, Auner, G, Iezzi, R, McAllister, P & Abrams, G 2003, Development of a microfluidic drug delivery neural prosthesis using a wide bandgap semiconductor waveguide structure. in H Becker & P Woias (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4982, pp. 330-339, Microfluidics, BioMEMS, and Medical Microsystems, San Jose, CA, United States, 1/27/03. https://doi.org/10.1117/12.478158
Safadi MR, Auner G, Iezzi R, McAllister P, Abrams G. Development of a microfluidic drug delivery neural prosthesis using a wide bandgap semiconductor waveguide structure. In Becker H, Woias P, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4982. 2003. p. 330-339 https://doi.org/10.1117/12.478158
Safadi, Mona R. ; Auner, Gregory ; Iezzi, Raymond ; McAllister, Pat ; Abrams, Gary. / Development of a microfluidic drug delivery neural prosthesis using a wide bandgap semiconductor waveguide structure. Proceedings of SPIE - The International Society for Optical Engineering. editor / H. Becker ; P. Woias. Vol. 4982 2003. pp. 330-339
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