Development of a microfluidic drug delivery neural prosthesis using a wide bandgap semiconductor waveguide structure

Mona R. Safadi, Gregory Auner, Raymond Iezzi, Pat McAllister, Gary Abrams

Research output: Contribution to journalConference article

4 Scopus citations

Abstract

We have developed a microfluidic retinal prosthesis, using wide bandgap optical wavelength semiconductor thin film waveguides, to facilitate spatial and quantitative photactivation of "caged" neurotransmitter to microfluidic channels. Novel waveguide materials and micromachining technology are necessary to fabricate 360 nanometer capable waveguides for the microfluidic device. Single crystal wide bandgap semiconductor thin films are grown on sapphire by plasma source molecular beam epitaxy (PSMBE). 248 nanometer KrF Excimer laser micromachining technology is employed to micro-fabricate wave-guiding channels and microfluidic structures. A waveguide that allows for spatial and temporal drug delivery within the retina was fabricated. In addition, there is a need for a waveguide structure that may be used in physiological drug delivery systems. A device that may deliver ultraviolet light in precise intensities and to selective areas of a microfluidic implant without direct ultraviolet exposure to the biological cells is needed in retinal and cortical implants. Results of a prototype microfluidic waveguide system will be presented.

Original languageEnglish (US)
Pages (from-to)330-339
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4982
DOIs
StatePublished - May 26 2003
EventMicrofluidics, BioMEMS, and Medical Microsystems - San Jose, CA, United States
Duration: Jan 27 2003Jan 29 2003

Keywords

  • Drug-Delivery
  • Excimer laser
  • Mi cromachining
  • Microfluidic
  • Semiconductor
  • Thin-film
  • Ultraviolet
  • Waveguide

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Development of a microfluidic drug delivery neural prosthesis using a wide bandgap semiconductor waveguide structure'. Together they form a unique fingerprint.

  • Cite this