Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change

I. M. Gralnek, R. Defranchis, E. Seidman, J. A. Leighton, P. Legnani, B. S. Lewis

Research output: Contribution to journalArticle

245 Scopus citations


Background: Capsule endoscopy can identify small bowel mucosal inflammatory change. However, there has been no validated index for capsule endoscopy findings. This manuscript documents the development of such an index. Aim: To develop a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Methods: The index was created in four separate steps. First, parameters and descriptors of inflammatory change were identified. Secondly, blinded readers prospectively graded the presence or absence of each parameter on de-identified videos and graded a perceived global assessment of overall severity. Thirdly, the individual parameters and descriptors were ranked in order of severity. Fourthly, values for each parameter were created using the descent gradient methodology. The premise was to assure that the final numerical score reflected the global assessment and that the global assessment agreed with the ranking of finding severity. Results were compiled for the three categories: no or clinically insignificant change, mild change, and moderate or severe change. Thresholds were determined. Results: The final index includes three parameters: villous oedema, ulcer and stenosis. A score <135 is designated normal or clinically insignificant mucosal inflammatory change, a score between 135 and 790 is mild, and a score ≥790 is moderate to severe. Conclusion: This capsule endoscopy score provides a common language to quantify small bowel inflammatory changes.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalAlimentary Pharmacology and Therapeutics
Issue number2
StatePublished - Jan 1 2008


ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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