TY - JOUR
T1 - Development of a biologic prosthetic composite for cartilage repair
AU - Mardones, Rodrigo M.
AU - Reinholz, Gregory G.
AU - Fitzsimmons, James S.
AU - Zobitz, Mark E.
AU - An, Kai Nan
AU - Lewallen, David G.
AU - Yaszemski, Michael J.
AU - O'Driscoll, Shawn W.
PY - 2005/9
Y1 - 2005/9
N2 - At present there is no satisfactory treatment for deep osteochondral defects. Here we report the development of a biologic prosthetic composite containing periosteum from 2-month-old rabbits and a porous tantalum scaffold. When cultured under chondrogenic conditions, the composites form a robust hyaline-like cartilage outgrowth that is attached to the porous scaffold by fibrous tissue ingrowth. The mechanical properties of these composites are similar to those of normal osteochondral plugs after only 6 weeks in culture. Thus, porous tantalum scaffolds are compatible with the chondrogenic capacity of periosteum. We hypothesize that these periosteum-porous tantalum composites will be useful for the repair of major osteochondral defects. However, in vivo experiments using biological resurfacing of large osteochondral defects with a porous tantalum scaffold and autologous periosteal graft in animal models are necessary to further explore this possibility. The implications of a successful method for cartilage regeneration would be great in terms of the number of patients affected and the quality of life for each of those patients.
AB - At present there is no satisfactory treatment for deep osteochondral defects. Here we report the development of a biologic prosthetic composite containing periosteum from 2-month-old rabbits and a porous tantalum scaffold. When cultured under chondrogenic conditions, the composites form a robust hyaline-like cartilage outgrowth that is attached to the porous scaffold by fibrous tissue ingrowth. The mechanical properties of these composites are similar to those of normal osteochondral plugs after only 6 weeks in culture. Thus, porous tantalum scaffolds are compatible with the chondrogenic capacity of periosteum. We hypothesize that these periosteum-porous tantalum composites will be useful for the repair of major osteochondral defects. However, in vivo experiments using biological resurfacing of large osteochondral defects with a porous tantalum scaffold and autologous periosteal graft in animal models are necessary to further explore this possibility. The implications of a successful method for cartilage regeneration would be great in terms of the number of patients affected and the quality of life for each of those patients.
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U2 - 10.1089/ten.2005.11.1368
DO - 10.1089/ten.2005.11.1368
M3 - Article
C2 - 16259592
AN - SCOPUS:27744589138
SN - 1076-3279
VL - 11
SP - 1368
EP - 1378
JO - Tissue Engineering
JF - Tissue Engineering
IS - 9-10
ER -