Development and validation of the emergency department assessment of chest pain score and 2h accelerated diagnostic protocol

Martin Than, Dylan Flaws, Sharon Sanders, Jenny Doust, Paul Glasziou, Jeffery Kline, Sally Aldous, Richard Troughton, Christopher Reid, William A. Parsonage, Christopher Frampton, Jaimi H. Greenslade, Joanne M. Deely, Erik Hess, Amr Bin Sadiq, Rose Singleton, Rosie Shopland, Laura Vercoe, Morgana Woolhouse-Williams, Michael ArdaghPatrick Bossuyt, Laura Bannister, Louise Cullen

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Objective: Risk scores and accelerated diagnostic protocols can identify chest pain patients with low risk of major adverse cardiac event who could be discharged early from the ED, saving time and costs. We aimed to derive and validate a chest pain score and accelerated diagnostic protocol (ADP) that could safely increase the proportion of patients suitable for early discharge. Methods: Logistic regression identified statistical predictors for major adverse cardiac events in a derivation cohort. Statistical coefficients were converted to whole numbers to create a score. Clinician feedback was used to improve the clinical plausibility and the usability of the final score (Emergency Department Assessment of Chest pain Score [EDACS]). EDACS was combined with electrocardiogram results and troponin results at 0 and 2h to develop an ADP (EDACS-ADP). The score and EDACS-ADP were validated and tested for reproducibility in separate cohorts of patients. Results: In the derivation (n = 1974) and validation (n = 608) cohorts, the EDACS-ADP classified 42.2% (sensitivity 99.0%, specificity 49.9%) and 51.3% (sensitivity 100.0%, specificity 59.0%) as low risk of major adverse cardiac events, respectively. The intra-class correlation coefficient for categorisation of patients as low risk was 0.87. Conclusion: The EDACS-ADP identified approximately half of the patients presenting to the ED with possible cardiac chest pain as having low risk of short-term major adverse cardiac events, with high sensitivity. This is a significant improvement on similar, previously reported protocols. The EDACS-ADP is reproducible and has the potential to make considerable cost reductions to health systems.

Original languageEnglish (US)
Pages (from-to)34-44
Number of pages11
JournalEMA - Emergency Medicine Australasia
Volume26
Issue number1
DOIs
StatePublished - Feb 2014

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Keywords

  • Accelerated diagnostic protocol
  • Acute coronary syndrome
  • Emergency department
  • Major adverse cardiac event
  • Risk score

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Than, M., Flaws, D., Sanders, S., Doust, J., Glasziou, P., Kline, J., Aldous, S., Troughton, R., Reid, C., Parsonage, W. A., Frampton, C., Greenslade, J. H., Deely, J. M., Hess, E., Sadiq, A. B., Singleton, R., Shopland, R., Vercoe, L., Woolhouse-Williams, M., ... Cullen, L. (2014). Development and validation of the emergency department assessment of chest pain score and 2h accelerated diagnostic protocol. EMA - Emergency Medicine Australasia, 26(1), 34-44. https://doi.org/10.1111/1742-6723.12164