Developing the ideal immunosuppressive protocol by internal audit

David Talbot, K. Suddeke Reddy, David Watson, Henry Pleass, John L.R. Forsythe, George Proud, R. M. Ross Taylor

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

To identify the best immunosuppressive protocol in a centre where five different regimens are employed, 227 consecutive renal recipients who were transplanted over a 2.5-year period were studied. The five different regimens employed were cyclosporin monotherapy, dual therapy (cyclosporin and prednisolone), triple therapy (cyclosporin, azathioprine, prednisolone), antithymocyte globulin (ATG) followed by dual therapy and ATG followed by triple therapy. Recipients were chosen for the different regimens according to HLA mismatch, positive donor crossmatch due to IgM, regraft and delayed graft function. The group with the lowest risk, cyclosporin monotherapy, had the highest acute rejection rate, with only 13% free of acute rejection (in comparison to triple immunosuppression, P=0.024, chi-square test). The overall infection rate and graft success rate were similar between the different groups.

Original languageEnglish (US)
Pages (from-to)392-395
Number of pages4
JournalTransplant International
Volume8
Issue number5
DOIs
StatePublished - Sep 1 1995

Keywords

  • Audit, immunosuppression
  • Immunosuppression, renal transplantation
  • Renal transplantation, immunosuppression

ASJC Scopus subject areas

  • Transplantation

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    Talbot, D., Reddy, K. S., Watson, D., Pleass, H., Forsythe, J. L. R., Proud, G., & Ross Taylor, R. M. (1995). Developing the ideal immunosuppressive protocol by internal audit. Transplant International, 8(5), 392-395. https://doi.org/10.1007/BF00337172