Determinants of renal volume in autosomal-dominant polycystic kidney disease

J. J. Grantham, L. T. Cook, Vicente Torres, J. E. Bost, A. B. Chapman, Peter C Harris, L. M. Guay-Woodford, K. T. Bae

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The Consortium of Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) recently showed that renal enlargement in autosomal-dominant polycystic kidney disease mimicked exponential growth. We determined the effects of cyst initiation rate, total number, and growth rate on the time-dependent change of total cyst volume (TCV). Mathematical models with equations integrating cyst surface area, volume, and an invariant growth rate constant were used to compute the time-dependent change in volume of solitary and multiple cysts. Multiple expanding cysts increased TCV in an exponential-like pattern even when individual cysts formed at different rates or exhibited different but constant growth rates. TCV depended on the rate of cyst initiation and on the total number of cysts; however, the compounding effect of exponential-like growth was the most powerful determinant of long-term cyst expansion. Extrapolation of TCV data plots for individual subjects back to an age of 18 predicted TCV values within an established range. We conclude that cysts started early in life were the main contributor to eventual TCV while their growth rate primarily determined renal size; although the rate of formation and the ultimate number of cysts also contributed. The good fit between the exponential models and the extrapolated CRISP data indicates that the TCV growth rate is a defining trait for individual patients and may be used as a prognostic marker.

Original languageEnglish (US)
Pages (from-to)108-116
Number of pages9
JournalKidney International
Volume73
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Autosomal Dominant Polycystic Kidney
Cysts
Kidney
Growth
Polycystic Kidney Diseases
Bone Cysts

Keywords

  • Cell growth
  • Polycystic kidney
  • Prolifiration cyst volume
  • Renal cysts
  • Tubules

ASJC Scopus subject areas

  • Nephrology

Cite this

Determinants of renal volume in autosomal-dominant polycystic kidney disease. / Grantham, J. J.; Cook, L. T.; Torres, Vicente; Bost, J. E.; Chapman, A. B.; Harris, Peter C; Guay-Woodford, L. M.; Bae, K. T.

In: Kidney International, Vol. 73, No. 1, 01.2008, p. 108-116.

Research output: Contribution to journalArticle

Grantham, JJ, Cook, LT, Torres, V, Bost, JE, Chapman, AB, Harris, PC, Guay-Woodford, LM & Bae, KT 2008, 'Determinants of renal volume in autosomal-dominant polycystic kidney disease', Kidney International, vol. 73, no. 1, pp. 108-116. https://doi.org/10.1038/sj.ki.5002624
Grantham, J. J. ; Cook, L. T. ; Torres, Vicente ; Bost, J. E. ; Chapman, A. B. ; Harris, Peter C ; Guay-Woodford, L. M. ; Bae, K. T. / Determinants of renal volume in autosomal-dominant polycystic kidney disease. In: Kidney International. 2008 ; Vol. 73, No. 1. pp. 108-116.
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