Abstract
The Consortium of Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) recently showed that renal enlargement in autosomal-dominant polycystic kidney disease mimicked exponential growth. We determined the effects of cyst initiation rate, total number, and growth rate on the time-dependent change of total cyst volume (TCV). Mathematical models with equations integrating cyst surface area, volume, and an invariant growth rate constant were used to compute the time-dependent change in volume of solitary and multiple cysts. Multiple expanding cysts increased TCV in an exponential-like pattern even when individual cysts formed at different rates or exhibited different but constant growth rates. TCV depended on the rate of cyst initiation and on the total number of cysts; however, the compounding effect of exponential-like growth was the most powerful determinant of long-term cyst expansion. Extrapolation of TCV data plots for individual subjects back to an age of 18 predicted TCV values within an established range. We conclude that cysts started early in life were the main contributor to eventual TCV while their growth rate primarily determined renal size; although the rate of formation and the ultimate number of cysts also contributed. The good fit between the exponential models and the extrapolated CRISP data indicates that the TCV growth rate is a defining trait for individual patients and may be used as a prognostic marker.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 108-116 |
| Number of pages | 9 |
| Journal | Kidney International |
| Volume | 73 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2008 |
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Keywords
- Cell growth
- Polycystic kidney
- Prolifiration cyst volume
- Renal cysts
- Tubules
ASJC Scopus subject areas
- Nephrology
Cite this
Determinants of renal volume in autosomal-dominant polycystic kidney disease. / Grantham, J. J.; Cook, L. T.; Torres, Vicente; Bost, J. E.; Chapman, A. B.; Harris, Peter C; Guay-Woodford, L. M.; Bae, K. T.
In: Kidney International, Vol. 73, No. 1, 01.2008, p. 108-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Determinants of renal volume in autosomal-dominant polycystic kidney disease
AU - Grantham, J. J.
AU - Cook, L. T.
AU - Torres, Vicente
AU - Bost, J. E.
AU - Chapman, A. B.
AU - Harris, Peter C
AU - Guay-Woodford, L. M.
AU - Bae, K. T.
PY - 2008/1
Y1 - 2008/1
N2 - The Consortium of Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) recently showed that renal enlargement in autosomal-dominant polycystic kidney disease mimicked exponential growth. We determined the effects of cyst initiation rate, total number, and growth rate on the time-dependent change of total cyst volume (TCV). Mathematical models with equations integrating cyst surface area, volume, and an invariant growth rate constant were used to compute the time-dependent change in volume of solitary and multiple cysts. Multiple expanding cysts increased TCV in an exponential-like pattern even when individual cysts formed at different rates or exhibited different but constant growth rates. TCV depended on the rate of cyst initiation and on the total number of cysts; however, the compounding effect of exponential-like growth was the most powerful determinant of long-term cyst expansion. Extrapolation of TCV data plots for individual subjects back to an age of 18 predicted TCV values within an established range. We conclude that cysts started early in life were the main contributor to eventual TCV while their growth rate primarily determined renal size; although the rate of formation and the ultimate number of cysts also contributed. The good fit between the exponential models and the extrapolated CRISP data indicates that the TCV growth rate is a defining trait for individual patients and may be used as a prognostic marker.
AB - The Consortium of Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) recently showed that renal enlargement in autosomal-dominant polycystic kidney disease mimicked exponential growth. We determined the effects of cyst initiation rate, total number, and growth rate on the time-dependent change of total cyst volume (TCV). Mathematical models with equations integrating cyst surface area, volume, and an invariant growth rate constant were used to compute the time-dependent change in volume of solitary and multiple cysts. Multiple expanding cysts increased TCV in an exponential-like pattern even when individual cysts formed at different rates or exhibited different but constant growth rates. TCV depended on the rate of cyst initiation and on the total number of cysts; however, the compounding effect of exponential-like growth was the most powerful determinant of long-term cyst expansion. Extrapolation of TCV data plots for individual subjects back to an age of 18 predicted TCV values within an established range. We conclude that cysts started early in life were the main contributor to eventual TCV while their growth rate primarily determined renal size; although the rate of formation and the ultimate number of cysts also contributed. The good fit between the exponential models and the extrapolated CRISP data indicates that the TCV growth rate is a defining trait for individual patients and may be used as a prognostic marker.
KW - Cell growth
KW - Polycystic kidney
KW - Prolifiration cyst volume
KW - Renal cysts
KW - Tubules
UR - http://www.scopus.com/inward/record.url?scp=37249043883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37249043883&partnerID=8YFLogxK
U2 - 10.1038/sj.ki.5002624
DO - 10.1038/sj.ki.5002624
M3 - Article
C2 - 17960141
AN - SCOPUS:37249043883
VL - 73
SP - 108
EP - 116
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 1
ER -