TY - JOUR
T1 - Determinants of pain interference and headache impact in patients who have chronic migraine with medication overuse
T2 - Results from the MOTS trial
AU - on behalf of the MOTS Investigators
AU - Schwedt, Todd J.
AU - Sahai-Srivastava, Soma
AU - Murinova, Natalia
AU - Birlea, Marius
AU - Ahmed, Zubair
AU - Digre, Kathleen
AU - Lopez, Kristina
AU - Mullally, William
AU - Blaya, Maike Tiede
AU - Pippitt, Karly
AU - Cutrer, Fred Michael
AU - DeLange, Justin
AU - Schecht, Howard
AU - Rizzoli, Paul
AU - Lane, Judy
AU - Wald, John
AU - Cortez, Melissa M.
AU - Martin, Vincent T.
AU - Spare, Nicole M.
AU - Hentz, Joseph G.
AU - Robert, Teri
AU - Dodick, David W.
N1 - Publisher Copyright:
© International Headache Society 2021.
PY - 2021/9
Y1 - 2021/9
N2 - Objective: “Pain interference” and “headache impact” refer to negative consequences that pain and headache have on one’s life. This study investigated determinants of these negative impacts in a large patient cohort who have chronic migraine with medication overuse. Methods: Six hundred and eleven adults were enrolled from 34 headache, neurology, and primary care clinics. Negative consequences of chronic migraine with medication overuse were determined using the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference 6b questionnaire and the Headache Impact Test 6. Relationships between PROMIS-6b and Headache Impact Test 6 scores with demographics, headache characteristics, medication use, anxiety symptoms, and depression symptoms were assessed with linear regression. Elastic Net regression was used to develop a multiple regression model. Results: PROMIS-6b T-Scores averaged 65.2 (SD 5.4) and Headache Impact Test 6 scores averaged 65.0 (SD 5.3), indicating severe negative consequences of chronic migraine with medication overuse. Chronic migraine with medication overuse interfered with enjoyment of life, concentration, daily activities, doing tasks away from home, and socializing. Depression symptom severity had the strongest relationship with pain interference and headache impact. Moderate-to-severe headache frequency, headache intensity, and anxiety symptoms were also associated with pain interference and headache impact. Conclusions: Chronic migraine with medication overuse is associated with substantial negative consequences, the extent of which is most strongly related to depression symptoms.
AB - Objective: “Pain interference” and “headache impact” refer to negative consequences that pain and headache have on one’s life. This study investigated determinants of these negative impacts in a large patient cohort who have chronic migraine with medication overuse. Methods: Six hundred and eleven adults were enrolled from 34 headache, neurology, and primary care clinics. Negative consequences of chronic migraine with medication overuse were determined using the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference 6b questionnaire and the Headache Impact Test 6. Relationships between PROMIS-6b and Headache Impact Test 6 scores with demographics, headache characteristics, medication use, anxiety symptoms, and depression symptoms were assessed with linear regression. Elastic Net regression was used to develop a multiple regression model. Results: PROMIS-6b T-Scores averaged 65.2 (SD 5.4) and Headache Impact Test 6 scores averaged 65.0 (SD 5.3), indicating severe negative consequences of chronic migraine with medication overuse. Chronic migraine with medication overuse interfered with enjoyment of life, concentration, daily activities, doing tasks away from home, and socializing. Depression symptom severity had the strongest relationship with pain interference and headache impact. Moderate-to-severe headache frequency, headache intensity, and anxiety symptoms were also associated with pain interference and headache impact. Conclusions: Chronic migraine with medication overuse is associated with substantial negative consequences, the extent of which is most strongly related to depression symptoms.
KW - Migraine
KW - disability
KW - headache
KW - medication overuse
KW - pain
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U2 - 10.1177/03331024211006903
DO - 10.1177/03331024211006903
M3 - Article
C2 - 33938249
AN - SCOPUS:85105874189
SN - 0333-1024
VL - 41
SP - 1053
EP - 1064
JO - Cephalalgia
JF - Cephalalgia
IS - 10
ER -