Determinants of 15-year outcome with 1,119 standard Carpentier-Edwards porcine valves

Donald D. Glower, Kevin P. Landolfo, Srinivas Cheruvu, Ye Ying Cen, J. Kevin Harrison, Thomas M. Bashore, Peter K. Smith, Robert H. Jones, Walter G. Wolfe, James E. Lowe

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Abstract

Background. The determinants of long-term outcome 15 years or more after porcine valve replacement are poorly documented. Methods. A retrospective review was performed of patients undergoing valve replacement with standard Carpentier-Edwards aortic (n = 531), mitral (n = 492), and tricuspid (n = 96) valves. Results. Patient survival was 26% ± 3%, 23% ± 2%, and 31% ± 8% 15 years after aortic, mitral, and tricuspid valve replacements, respectively. Independent determinants of impaired long-term survival for aortic or mitral valve replacement were multiple valve replacement, older age, renal disease, lung disease, or coronary disease. Actual (versus actuarial) freedom from reoperation at 15 years was 86% ± 2%, 76% ± 2%, and 95% ± 2% after aortic, mitral, and tricuspid valve replacement, respectively. Risk factors for reoperation were young age for aortic or mitral valve replacement, previous operation for aortic valve replacement, and large valve size for mitral valve replacement. Freedom from thromboembolism was 77% ± 4%, 62% ± 9%, and 80% ± 5%; from hemorrhage, 95% ± 5%, 87% ± 4%, and 82% ± 6%; and from endocarditis, 94% ± 1%, 96% ± 1%, and 89% ± 5% 15 years after aortic, mitral, and tricuspid valve replacement, respectively. Risk factors for thromboembolism or hemorrhage were multiple valve replacement and age. Conclusions. The standard Carpentier-Edwards bioprosthesis continues to provide relatively low complication rates at 15 years, especially in the aortic and tricuspid positions, and especially in patients older than 60 years or with significant comorbdity.

Original languageEnglish (US)
JournalAnnals of Thoracic Surgery
Volume66
Issue number6 SUPPL.
DOIs
StatePublished - Dec 1998
Externally publishedYes

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Aortic Valve
Mitral Valve
Swine
Tricuspid Valve
Thromboembolism
Reoperation
Hemorrhage
Bioprosthesis
Survival
Endocarditis
Lung Diseases
Coronary Disease
Kidney

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Glower, D. D., Landolfo, K. P., Cheruvu, S., Cen, Y. Y., Harrison, J. K., Bashore, T. M., ... Lowe, J. E. (1998). Determinants of 15-year outcome with 1,119 standard Carpentier-Edwards porcine valves. Annals of Thoracic Surgery, 66(6 SUPPL.). https://doi.org/10.1016/S0003-4975(98)01114-X

Determinants of 15-year outcome with 1,119 standard Carpentier-Edwards porcine valves. / Glower, Donald D.; Landolfo, Kevin P.; Cheruvu, Srinivas; Cen, Ye Ying; Harrison, J. Kevin; Bashore, Thomas M.; Smith, Peter K.; Jones, Robert H.; Wolfe, Walter G.; Lowe, James E.

In: Annals of Thoracic Surgery, Vol. 66, No. 6 SUPPL., 12.1998.

Research output: Contribution to journalArticle

Glower, DD, Landolfo, KP, Cheruvu, S, Cen, YY, Harrison, JK, Bashore, TM, Smith, PK, Jones, RH, Wolfe, WG & Lowe, JE 1998, 'Determinants of 15-year outcome with 1,119 standard Carpentier-Edwards porcine valves', Annals of Thoracic Surgery, vol. 66, no. 6 SUPPL.. https://doi.org/10.1016/S0003-4975(98)01114-X
Glower, Donald D. ; Landolfo, Kevin P. ; Cheruvu, Srinivas ; Cen, Ye Ying ; Harrison, J. Kevin ; Bashore, Thomas M. ; Smith, Peter K. ; Jones, Robert H. ; Wolfe, Walter G. ; Lowe, James E. / Determinants of 15-year outcome with 1,119 standard Carpentier-Edwards porcine valves. In: Annals of Thoracic Surgery. 1998 ; Vol. 66, No. 6 SUPPL.
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abstract = "Background. The determinants of long-term outcome 15 years or more after porcine valve replacement are poorly documented. Methods. A retrospective review was performed of patients undergoing valve replacement with standard Carpentier-Edwards aortic (n = 531), mitral (n = 492), and tricuspid (n = 96) valves. Results. Patient survival was 26{\%} ± 3{\%}, 23{\%} ± 2{\%}, and 31{\%} ± 8{\%} 15 years after aortic, mitral, and tricuspid valve replacements, respectively. Independent determinants of impaired long-term survival for aortic or mitral valve replacement were multiple valve replacement, older age, renal disease, lung disease, or coronary disease. Actual (versus actuarial) freedom from reoperation at 15 years was 86{\%} ± 2{\%}, 76{\%} ± 2{\%}, and 95{\%} ± 2{\%} after aortic, mitral, and tricuspid valve replacement, respectively. Risk factors for reoperation were young age for aortic or mitral valve replacement, previous operation for aortic valve replacement, and large valve size for mitral valve replacement. Freedom from thromboembolism was 77{\%} ± 4{\%}, 62{\%} ± 9{\%}, and 80{\%} ± 5{\%}; from hemorrhage, 95{\%} ± 5{\%}, 87{\%} ± 4{\%}, and 82{\%} ± 6{\%}; and from endocarditis, 94{\%} ± 1{\%}, 96{\%} ± 1{\%}, and 89{\%} ± 5{\%} 15 years after aortic, mitral, and tricuspid valve replacement, respectively. Risk factors for thromboembolism or hemorrhage were multiple valve replacement and age. Conclusions. The standard Carpentier-Edwards bioprosthesis continues to provide relatively low complication rates at 15 years, especially in the aortic and tricuspid positions, and especially in patients older than 60 years or with significant comorbdity.",
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T1 - Determinants of 15-year outcome with 1,119 standard Carpentier-Edwards porcine valves

AU - Glower, Donald D.

AU - Landolfo, Kevin P.

AU - Cheruvu, Srinivas

AU - Cen, Ye Ying

AU - Harrison, J. Kevin

AU - Bashore, Thomas M.

AU - Smith, Peter K.

AU - Jones, Robert H.

AU - Wolfe, Walter G.

AU - Lowe, James E.

PY - 1998/12

Y1 - 1998/12

N2 - Background. The determinants of long-term outcome 15 years or more after porcine valve replacement are poorly documented. Methods. A retrospective review was performed of patients undergoing valve replacement with standard Carpentier-Edwards aortic (n = 531), mitral (n = 492), and tricuspid (n = 96) valves. Results. Patient survival was 26% ± 3%, 23% ± 2%, and 31% ± 8% 15 years after aortic, mitral, and tricuspid valve replacements, respectively. Independent determinants of impaired long-term survival for aortic or mitral valve replacement were multiple valve replacement, older age, renal disease, lung disease, or coronary disease. Actual (versus actuarial) freedom from reoperation at 15 years was 86% ± 2%, 76% ± 2%, and 95% ± 2% after aortic, mitral, and tricuspid valve replacement, respectively. Risk factors for reoperation were young age for aortic or mitral valve replacement, previous operation for aortic valve replacement, and large valve size for mitral valve replacement. Freedom from thromboembolism was 77% ± 4%, 62% ± 9%, and 80% ± 5%; from hemorrhage, 95% ± 5%, 87% ± 4%, and 82% ± 6%; and from endocarditis, 94% ± 1%, 96% ± 1%, and 89% ± 5% 15 years after aortic, mitral, and tricuspid valve replacement, respectively. Risk factors for thromboembolism or hemorrhage were multiple valve replacement and age. Conclusions. The standard Carpentier-Edwards bioprosthesis continues to provide relatively low complication rates at 15 years, especially in the aortic and tricuspid positions, and especially in patients older than 60 years or with significant comorbdity.

AB - Background. The determinants of long-term outcome 15 years or more after porcine valve replacement are poorly documented. Methods. A retrospective review was performed of patients undergoing valve replacement with standard Carpentier-Edwards aortic (n = 531), mitral (n = 492), and tricuspid (n = 96) valves. Results. Patient survival was 26% ± 3%, 23% ± 2%, and 31% ± 8% 15 years after aortic, mitral, and tricuspid valve replacements, respectively. Independent determinants of impaired long-term survival for aortic or mitral valve replacement were multiple valve replacement, older age, renal disease, lung disease, or coronary disease. Actual (versus actuarial) freedom from reoperation at 15 years was 86% ± 2%, 76% ± 2%, and 95% ± 2% after aortic, mitral, and tricuspid valve replacement, respectively. Risk factors for reoperation were young age for aortic or mitral valve replacement, previous operation for aortic valve replacement, and large valve size for mitral valve replacement. Freedom from thromboembolism was 77% ± 4%, 62% ± 9%, and 80% ± 5%; from hemorrhage, 95% ± 5%, 87% ± 4%, and 82% ± 6%; and from endocarditis, 94% ± 1%, 96% ± 1%, and 89% ± 5% 15 years after aortic, mitral, and tricuspid valve replacement, respectively. Risk factors for thromboembolism or hemorrhage were multiple valve replacement and age. Conclusions. The standard Carpentier-Edwards bioprosthesis continues to provide relatively low complication rates at 15 years, especially in the aortic and tricuspid positions, and especially in patients older than 60 years or with significant comorbdity.

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