Einteilung des Schweregrads der akuten Pankreatitis: Internationale, multidisziplinäre klinische Klassifikation auf Basis pathogenetischer Determinanten: Deutsche Version 2013

Translated title of the contribution: Determinant-based classification of acute pancreatitis severity: International multidisciplinary classification of acute pancreatitis severity: The 2013 German Edition

E. Patchen Dellinger, Christopher E. Forsmark, Peter Layer, Philippe Levy, Enrique Maraví-Poma, Maxim S. Petrov, Tooru Shimosegawa, Ajith K. Siriwardena, Generoso Uomo, David C. Whitcomb, John A. Windsor, M. Abu Hilal, F. M. Abu-Zidan, J. M. Acosta, A. P. Ainsworth, M. Aizcorbe Garralda, H. Alagozlu, S. J. Al'aref, E. Albeniz Arbizu, A. AlhajeriI. C. Almeida, J. L. Almeida, H. Amano, B. J. Ammori, R. Andersson, A. Andrén-Sandberg, J. C. Ardengh, A. S. Arroyo-Sanchez, M. Arvanitakis, S. W. Ashley, G. Aygencel, W. A. Ayoub, J. Baillie, M. Bala, C. G. Ball, T. H. Baron, S. G. Barreto, M. Basaranoglu, H. G. Beger, V. Bernal Monterde, N. Bharwani, D. K. Bhasin, J. J. Bong, G. Botoi, T. Bruennler, E. Cairoli, C. R. Carter, D. Cernea, Suresh T Chari, R. M. Charnley, S. Chooklin, D. Cochior, C. Col, D. L. Conwell, M. I. Correia, Z. Dambrauskas, K. Darvas, T. De Campos, G. G. De Casasola, J. J. De Waele, M. Del Chiaro, G. Delle Fave, E. P. Dellinger, E. De-Madaria, P. Di Sebastiano, T. G. Diuzheva, A. Duarte-Rojo, P. J. Fagenholz, G. Farkas, A. Farre Viladrich, C. Fernandezdel Castillo, C. E. Forsmark, H. Friess, J. L. Frossard, V. Gandhi, T. B. Gardner, B. Gloor, M. Gluk, V. R. Goltsov, J. Guevara-Campos, A. A. Gumbs, T. Hackert, G. Hauser, K. D. Horvath, T. J. Howard, H. Igarashi, O. Ioannidis, S. Jaber, F. E. James, R. K. Jha, D. Juneja, T. Kamisawa, P. Kandasami, M. Kantarcioglu, V. K. Kapoor, T. Karakan, E. Kaya, A. Khaliq, S. Kiriyama, R. Kochhar, G. N. Konstantinou, M. L. Kylänpää, P. G. Lankisch, C. Laplaza Santos, J. Lata, P. Layer, A. Leppäniemi, P. Levy, A. Lopez, V. López Camps, L. A. Lujano-Nicolas, H. Lund, D. Lytras, L. Macaya Redin, M. C. Machado, M. A. Macias Rodriguez, O. Mann, E. Maravi-Poma, M. Marincas, S. Marwah, E. Mas, A. S. Matheus, R. Meier, D. Mennecier, P. Mentula, A. Mifkovic, R. Mofidi, D. J. Mole, G. Morris-Stiff, J. Mossner, M. A. Muftuoglu, M. A. Munsell, A. B. Nathens, V. Neri, C. Nöjgaard, I. Nordback, C. Ocampo, A. Oláh, J. Olejnik, D. A. O'Reilly, A. Oria, J. Panek, G. I. Papachristou, D. Parekh, R. W. Parks, C. Passaglia, C. B. Pearce, D. Pellegrini, M. Perez-Mateo, M. S. Petrov, V. Pettila, R. Pezzilli, C. S. Pitchumoni, S. Pongprasobchai, I. Poves Prim, P. Puolakkainen, G. Pupelis, D. V. Radenkovic, S. H. Rahman, E. Regidor Sanz, A. Repiso, L. Rodrigo, A. Rosseland, G. Rydzewska, J. A. Sánchez-Izquierdo Riera, T. J. Savides, M. Scaglione, A. Serrablo, E. Servin-Torres, I. Sethu, O. Sezgin, M. Shankar-Hari, T. Shimosegawa, M. V. Singer, S. K. Sinha, A. K. Siriwardena, T. Sjoberg Bexelius, J. R. Skipworth, F. G. Soriano, R. Sotoudehmanesh, B. W. Spanier, B. Stabuc, C. Stroescu, Z. Szentkereszty, T. Takacs, T. Takada, K. Takeda, Y. Takeyama, W. Tang, K. Tanjoh, P. R. Tarnasky, N. Teich, J. M. Tellado, S. Tenner, A. Thomson, M. Tireli, Z. Tong, C. Triantopoulou, G. Uomo, M. C. Uy, E. J. Van Geenen, A. Velasco Guardado, N. Vettoretto, C. M. Vollmer, K. Wada, A. L. Warshaw, A. A. Weinbroum, D. C. Whitcomb, J. S. Wilson, J. A. Windsor, M. Wittau, B. U. Wu, A. P. Wysocki, E. Yan Quiros, T. Yasuda, C. Yu, E. Zerem, X. Zhou, F. Zubia Olazcoaga, N. J. Zyromski

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To develop a new classification of acute pancreatitis severity on the basis of a sound conceptual framework, comprehensive review of published evidence, and worldwide consultation. Background: The Atlanta definitions of acute pancreatitis severity are ingrained in the lexicon of pancreatologists but suboptimal because these definitions are based on empiric description of occurrences that are merely associated with severity. Methods: A personal invitation to contribute to the development of a new classification of acute pancreatitis severity was sent to all surgeons, gastroen-terologists, internists, intensivists, and radiologists who are currently active in clinical research on acute pancreatitis. The invitation was not limited to members of certain associations or residents of certain countries. A global Web-based survey was conducted and a dedicated international symposium was organized to bring contributors from different disciplines together and discuss the concept and definitions. Result: The new classification of severity is based on the actual local and systemic determinants of severity, rather than description of events that are correlated with severity. The local determinant relates to whether there is (peri)pancreatic necrosis or not, and if present, whether it is sterile or infected. The systemic determinant relates to whether there is organ failure or not, and if present, whether it is transient or persistent. The presence of one determinant can modify the effect of another such that the presence of both infected (peri)pancreatic necrosis and persistent organ failure have a greater effect on severity than either determinant alone. The derivation of a classification based on the above principles results in 4 categories of severity-mild, moderate, severe, and critical. Conclusions: This classification is the result of a consultative process amongst pancreatologists from 49 countries. It provides a set of concise up-to-date definitions of all the main entities pertinent to classifying the severity of acute pancreatitis in clinical practice and research. This ensures that the determinant-based classification can be used in a uniform manner throughout the world.

Original languageGerman
Pages (from-to)544-550
Number of pages7
JournalZeitschrift fur Gastroenterologie
Volume51
Issue number6
DOIs
StatePublished - Jan 1 2013

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Pancreatitis
Necrosis
Research
Referral and Consultation

Keywords

  • acute pancreatitis
  • classification
  • definition
  • organ failure
  • pancreatic infectious complications
  • pancreatic necrosis
  • peripancreatic necrosis
  • severity

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Einteilung des Schweregrads der akuten Pankreatitis : Internationale, multidisziplinäre klinische Klassifikation auf Basis pathogenetischer Determinanten: Deutsche Version 2013. / Dellinger, E. Patchen; Forsmark, Christopher E.; Layer, Peter; Levy, Philippe; Maraví-Poma, Enrique; Petrov, Maxim S.; Shimosegawa, Tooru; Siriwardena, Ajith K.; Uomo, Generoso; Whitcomb, David C.; Windsor, John A.; Abu Hilal, M.; Abu-Zidan, F. M.; Acosta, J. M.; Ainsworth, A. P.; Aizcorbe Garralda, M.; Alagozlu, H.; Al'aref, S. J.; Albeniz Arbizu, E.; Alhajeri, A.; Almeida, I. C.; Almeida, J. L.; Amano, H.; Ammori, B. J.; Andersson, R.; Andrén-Sandberg, A.; Ardengh, J. C.; Arroyo-Sanchez, A. S.; Arvanitakis, M.; Ashley, S. W.; Aygencel, G.; Ayoub, W. A.; Baillie, J.; Bala, M.; Ball, C. G.; Baron, T. H.; Barreto, S. G.; Basaranoglu, M.; Beger, H. G.; Bernal Monterde, V.; Bharwani, N.; Bhasin, D. K.; Bong, J. J.; Botoi, G.; Bruennler, T.; Cairoli, E.; Carter, C. R.; Cernea, D.; Chari, Suresh T; Charnley, R. M.; Chooklin, S.; Cochior, D.; Col, C.; Conwell, D. L.; Correia, M. I.; Dambrauskas, Z.; Darvas, K.; De Campos, T.; De Casasola, G. G.; De Waele, J. J.; Del Chiaro, M.; Delle Fave, G.; Dellinger, E. P.; De-Madaria, E.; Di Sebastiano, P.; Diuzheva, T. G.; Duarte-Rojo, A.; Fagenholz, P. J.; Farkas, G.; Farre Viladrich, A.; Fernandezdel Castillo, C.; Forsmark, C. E.; Friess, H.; Frossard, J. L.; Gandhi, V.; Gardner, T. B.; Gloor, B.; Gluk, M.; Goltsov, V. R.; Guevara-Campos, J.; Gumbs, A. A.; Hackert, T.; Hauser, G.; Horvath, K. D.; Howard, T. J.; Igarashi, H.; Ioannidis, O.; Jaber, S.; James, F. E.; Jha, R. K.; Juneja, D.; Kamisawa, T.; Kandasami, P.; Kantarcioglu, M.; Kapoor, V. K.; Karakan, T.; Kaya, E.; Khaliq, A.; Kiriyama, S.; Kochhar, R.; Konstantinou, G. N.; Kylänpää, M. L.; Lankisch, P. G.; Laplaza Santos, C.; Lata, J.; Layer, P.; Leppäniemi, A.; Levy, P.; Lopez, A.; López Camps, V.; Lujano-Nicolas, L. A.; Lund, H.; Lytras, D.; Macaya Redin, L.; Machado, M. C.; Macias Rodriguez, M. A.; Mann, O.; Maravi-Poma, E.; Marincas, M.; Marwah, S.; Mas, E.; Matheus, A. S.; Meier, R.; Mennecier, D.; Mentula, P.; Mifkovic, A.; Mofidi, R.; Mole, D. J.; Morris-Stiff, G.; Mossner, J.; Muftuoglu, M. A.; Munsell, M. A.; Nathens, A. B.; Neri, V.; Nöjgaard, C.; Nordback, I.; Ocampo, C.; Oláh, A.; Olejnik, J.; O'Reilly, D. A.; Oria, A.; Panek, J.; Papachristou, G. I.; Parekh, D.; Parks, R. W.; Passaglia, C.; Pearce, C. B.; Pellegrini, D.; Perez-Mateo, M.; Petrov, M. S.; Pettila, V.; Pezzilli, R.; Pitchumoni, C. S.; Pongprasobchai, S.; Poves Prim, I.; Puolakkainen, P.; Pupelis, G.; Radenkovic, D. V.; Rahman, S. H.; Regidor Sanz, E.; Repiso, A.; Rodrigo, L.; Rosseland, A.; Rydzewska, G.; Sánchez-Izquierdo Riera, J. A.; Savides, T. J.; Scaglione, M.; Serrablo, A.; Servin-Torres, E.; Sethu, I.; Sezgin, O.; Shankar-Hari, M.; Shimosegawa, T.; Singer, M. V.; Sinha, S. K.; Siriwardena, A. K.; Sjoberg Bexelius, T.; Skipworth, J. R.; Soriano, F. G.; Sotoudehmanesh, R.; Spanier, B. W.; Stabuc, B.; Stroescu, C.; Szentkereszty, Z.; Takacs, T.; Takada, T.; Takeda, K.; Takeyama, Y.; Tang, W.; Tanjoh, K.; Tarnasky, P. R.; Teich, N.; Tellado, J. M.; Tenner, S.; Thomson, A.; Tireli, M.; Tong, Z.; Triantopoulou, C.; Uomo, G.; Uy, M. C.; Van Geenen, E. J.; Velasco Guardado, A.; Vettoretto, N.; Vollmer, C. M.; Wada, K.; Warshaw, A. L.; Weinbroum, A. A.; Whitcomb, D. C.; Wilson, J. S.; Windsor, J. A.; Wittau, M.; Wu, B. U.; Wysocki, A. P.; Yan Quiros, E.; Yasuda, T.; Yu, C.; Zerem, E.; Zhou, X.; Zubia Olazcoaga, F.; Zyromski, N. J.

In: Zeitschrift fur Gastroenterologie, Vol. 51, No. 6, 01.01.2013, p. 544-550.

Research output: Contribution to journalArticle

Dellinger, EP, Forsmark, CE, Layer, P, Levy, P, Maraví-Poma, E, Petrov, MS, Shimosegawa, T, Siriwardena, AK, Uomo, G, Whitcomb, DC, Windsor, JA, Abu Hilal, M, Abu-Zidan, FM, Acosta, JM, Ainsworth, AP, Aizcorbe Garralda, M, Alagozlu, H, Al'aref, SJ, Albeniz Arbizu, E, Alhajeri, A, Almeida, IC, Almeida, JL, Amano, H, Ammori, BJ, Andersson, R, Andrén-Sandberg, A, Ardengh, JC, Arroyo-Sanchez, AS, Arvanitakis, M, Ashley, SW, Aygencel, G, Ayoub, WA, Baillie, J, Bala, M, Ball, CG, Baron, TH, Barreto, SG, Basaranoglu, M, Beger, HG, Bernal Monterde, V, Bharwani, N, Bhasin, DK, Bong, JJ, Botoi, G, Bruennler, T, Cairoli, E, Carter, CR, Cernea, D, Chari, ST, Charnley, RM, Chooklin, S, Cochior, D, Col, C, Conwell, DL, Correia, MI, Dambrauskas, Z, Darvas, K, De Campos, T, De Casasola, GG, De Waele, JJ, Del Chiaro, M, Delle Fave, G, Dellinger, EP, De-Madaria, E, Di Sebastiano, P, Diuzheva, TG, Duarte-Rojo, A, Fagenholz, PJ, Farkas, G, Farre Viladrich, A, Fernandezdel Castillo, C, Forsmark, CE, Friess, H, Frossard, JL, Gandhi, V, Gardner, TB, Gloor, B, Gluk, M, Goltsov, VR, Guevara-Campos, J, Gumbs, AA, Hackert, T, Hauser, G, Horvath, KD, Howard, TJ, Igarashi, H, Ioannidis, O, Jaber, S, James, FE, Jha, RK, Juneja, D, Kamisawa, T, Kandasami, P, Kantarcioglu, M, Kapoor, VK, Karakan, T, Kaya, E, Khaliq, A, Kiriyama, S, Kochhar, R, Konstantinou, GN, Kylänpää, ML, Lankisch, PG, Laplaza Santos, C, Lata, J, Layer, P, Leppäniemi, A, Levy, P, Lopez, A, López Camps, V, Lujano-Nicolas, LA, Lund, H, Lytras, D, Macaya Redin, L, Machado, MC, Macias Rodriguez, MA, Mann, O, Maravi-Poma, E, Marincas, M, Marwah, S, Mas, E, Matheus, AS, Meier, R, Mennecier, D, Mentula, P, Mifkovic, A, Mofidi, R, Mole, DJ, Morris-Stiff, G, Mossner, J, Muftuoglu, MA, Munsell, MA, Nathens, AB, Neri, V, Nöjgaard, C, Nordback, I, Ocampo, C, Oláh, A, Olejnik, J, O'Reilly, DA, Oria, A, Panek, J, Papachristou, GI, Parekh, D, Parks, RW, Passaglia, C, Pearce, CB, Pellegrini, D, Perez-Mateo, M, Petrov, MS, Pettila, V, Pezzilli, R, Pitchumoni, CS, Pongprasobchai, S, Poves Prim, I, Puolakkainen, P, Pupelis, G, Radenkovic, DV, Rahman, SH, Regidor Sanz, E, Repiso, A, Rodrigo, L, Rosseland, A, Rydzewska, G, Sánchez-Izquierdo Riera, JA, Savides, TJ, Scaglione, M, Serrablo, A, Servin-Torres, E, Sethu, I, Sezgin, O, Shankar-Hari, M, Shimosegawa, T, Singer, MV, Sinha, SK, Siriwardena, AK, Sjoberg Bexelius, T, Skipworth, JR, Soriano, FG, Sotoudehmanesh, R, Spanier, BW, Stabuc, B, Stroescu, C, Szentkereszty, Z, Takacs, T, Takada, T, Takeda, K, Takeyama, Y, Tang, W, Tanjoh, K, Tarnasky, PR, Teich, N, Tellado, JM, Tenner, S, Thomson, A, Tireli, M, Tong, Z, Triantopoulou, C, Uomo, G, Uy, MC, Van Geenen, EJ, Velasco Guardado, A, Vettoretto, N, Vollmer, CM, Wada, K, Warshaw, AL, Weinbroum, AA, Whitcomb, DC, Wilson, JS, Windsor, JA, Wittau, M, Wu, BU, Wysocki, AP, Yan Quiros, E, Yasuda, T, Yu, C, Zerem, E, Zhou, X, Zubia Olazcoaga, F & Zyromski, NJ 2013, 'Einteilung des Schweregrads der akuten Pankreatitis: Internationale, multidisziplinäre klinische Klassifikation auf Basis pathogenetischer Determinanten: Deutsche Version 2013', Zeitschrift fur Gastroenterologie, vol. 51, no. 6, pp. 544-550. https://doi.org/10.1055/s-0033-1335526
Dellinger, E. Patchen ; Forsmark, Christopher E. ; Layer, Peter ; Levy, Philippe ; Maraví-Poma, Enrique ; Petrov, Maxim S. ; Shimosegawa, Tooru ; Siriwardena, Ajith K. ; Uomo, Generoso ; Whitcomb, David C. ; Windsor, John A. ; Abu Hilal, M. ; Abu-Zidan, F. M. ; Acosta, J. M. ; Ainsworth, A. P. ; Aizcorbe Garralda, M. ; Alagozlu, H. ; Al'aref, S. J. ; Albeniz Arbizu, E. ; Alhajeri, A. ; Almeida, I. C. ; Almeida, J. L. ; Amano, H. ; Ammori, B. J. ; Andersson, R. ; Andrén-Sandberg, A. ; Ardengh, J. C. ; Arroyo-Sanchez, A. S. ; Arvanitakis, M. ; Ashley, S. W. ; Aygencel, G. ; Ayoub, W. A. ; Baillie, J. ; Bala, M. ; Ball, C. G. ; Baron, T. H. ; Barreto, S. G. ; Basaranoglu, M. ; Beger, H. G. ; Bernal Monterde, V. ; Bharwani, N. ; Bhasin, D. K. ; Bong, J. J. ; Botoi, G. ; Bruennler, T. ; Cairoli, E. ; Carter, C. R. ; Cernea, D. ; Chari, Suresh T ; Charnley, R. M. ; Chooklin, S. ; Cochior, D. ; Col, C. ; Conwell, D. L. ; Correia, M. I. ; Dambrauskas, Z. ; Darvas, K. ; De Campos, T. ; De Casasola, G. G. ; De Waele, J. J. ; Del Chiaro, M. ; Delle Fave, G. ; Dellinger, E. P. ; De-Madaria, E. ; Di Sebastiano, P. ; Diuzheva, T. G. ; Duarte-Rojo, A. ; Fagenholz, P. J. ; Farkas, G. ; Farre Viladrich, A. ; Fernandezdel Castillo, C. ; Forsmark, C. E. ; Friess, H. ; Frossard, J. L. ; Gandhi, V. ; Gardner, T. B. ; Gloor, B. ; Gluk, M. ; Goltsov, V. R. ; Guevara-Campos, J. ; Gumbs, A. A. ; Hackert, T. ; Hauser, G. ; Horvath, K. D. ; Howard, T. J. ; Igarashi, H. ; Ioannidis, O. ; Jaber, S. ; James, F. E. ; Jha, R. K. ; Juneja, D. ; Kamisawa, T. ; Kandasami, P. ; Kantarcioglu, M. ; Kapoor, V. K. ; Karakan, T. ; Kaya, E. ; Khaliq, A. ; Kiriyama, S. ; Kochhar, R. ; Konstantinou, G. N. ; Kylänpää, M. L. ; Lankisch, P. G. ; Laplaza Santos, C. ; Lata, J. ; Layer, P. ; Leppäniemi, A. ; Levy, P. ; Lopez, A. ; López Camps, V. ; Lujano-Nicolas, L. A. ; Lund, H. ; Lytras, D. ; Macaya Redin, L. ; Machado, M. C. ; Macias Rodriguez, M. A. ; Mann, O. ; Maravi-Poma, E. ; Marincas, M. ; Marwah, S. ; Mas, E. ; Matheus, A. S. ; Meier, R. ; Mennecier, D. ; Mentula, P. ; Mifkovic, A. ; Mofidi, R. ; Mole, D. J. ; Morris-Stiff, G. ; Mossner, J. ; Muftuoglu, M. A. ; Munsell, M. A. ; Nathens, A. B. ; Neri, V. ; Nöjgaard, C. ; Nordback, I. ; Ocampo, C. ; Oláh, A. ; Olejnik, J. ; O'Reilly, D. A. ; Oria, A. ; Panek, J. ; Papachristou, G. I. ; Parekh, D. ; Parks, R. W. ; Passaglia, C. ; Pearce, C. B. ; Pellegrini, D. ; Perez-Mateo, M. ; Petrov, M. S. ; Pettila, V. ; Pezzilli, R. ; Pitchumoni, C. S. ; Pongprasobchai, S. ; Poves Prim, I. ; Puolakkainen, P. ; Pupelis, G. ; Radenkovic, D. V. ; Rahman, S. H. ; Regidor Sanz, E. ; Repiso, A. ; Rodrigo, L. ; Rosseland, A. ; Rydzewska, G. ; Sánchez-Izquierdo Riera, J. A. ; Savides, T. J. ; Scaglione, M. ; Serrablo, A. ; Servin-Torres, E. ; Sethu, I. ; Sezgin, O. ; Shankar-Hari, M. ; Shimosegawa, T. ; Singer, M. V. ; Sinha, S. K. ; Siriwardena, A. K. ; Sjoberg Bexelius, T. ; Skipworth, J. R. ; Soriano, F. G. ; Sotoudehmanesh, R. ; Spanier, B. W. ; Stabuc, B. ; Stroescu, C. ; Szentkereszty, Z. ; Takacs, T. ; Takada, T. ; Takeda, K. ; Takeyama, Y. ; Tang, W. ; Tanjoh, K. ; Tarnasky, P. R. ; Teich, N. ; Tellado, J. M. ; Tenner, S. ; Thomson, A. ; Tireli, M. ; Tong, Z. ; Triantopoulou, C. ; Uomo, G. ; Uy, M. C. ; Van Geenen, E. J. ; Velasco Guardado, A. ; Vettoretto, N. ; Vollmer, C. M. ; Wada, K. ; Warshaw, A. L. ; Weinbroum, A. A. ; Whitcomb, D. C. ; Wilson, J. S. ; Windsor, J. A. ; Wittau, M. ; Wu, B. U. ; Wysocki, A. P. ; Yan Quiros, E. ; Yasuda, T. ; Yu, C. ; Zerem, E. ; Zhou, X. ; Zubia Olazcoaga, F. ; Zyromski, N. J. / Einteilung des Schweregrads der akuten Pankreatitis : Internationale, multidisziplinäre klinische Klassifikation auf Basis pathogenetischer Determinanten: Deutsche Version 2013. In: Zeitschrift fur Gastroenterologie. 2013 ; Vol. 51, No. 6. pp. 544-550.
@article{2ce4e633d05a44118aad56de941765ec,
title = "Einteilung des Schweregrads der akuten Pankreatitis: Internationale, multidisziplin{\"a}re klinische Klassifikation auf Basis pathogenetischer Determinanten: Deutsche Version 2013",
abstract = "Objective: To develop a new classification of acute pancreatitis severity on the basis of a sound conceptual framework, comprehensive review of published evidence, and worldwide consultation. Background: The Atlanta definitions of acute pancreatitis severity are ingrained in the lexicon of pancreatologists but suboptimal because these definitions are based on empiric description of occurrences that are merely associated with severity. Methods: A personal invitation to contribute to the development of a new classification of acute pancreatitis severity was sent to all surgeons, gastroen-terologists, internists, intensivists, and radiologists who are currently active in clinical research on acute pancreatitis. The invitation was not limited to members of certain associations or residents of certain countries. A global Web-based survey was conducted and a dedicated international symposium was organized to bring contributors from different disciplines together and discuss the concept and definitions. Result: The new classification of severity is based on the actual local and systemic determinants of severity, rather than description of events that are correlated with severity. The local determinant relates to whether there is (peri)pancreatic necrosis or not, and if present, whether it is sterile or infected. The systemic determinant relates to whether there is organ failure or not, and if present, whether it is transient or persistent. The presence of one determinant can modify the effect of another such that the presence of both infected (peri)pancreatic necrosis and persistent organ failure have a greater effect on severity than either determinant alone. The derivation of a classification based on the above principles results in 4 categories of severity-mild, moderate, severe, and critical. Conclusions: This classification is the result of a consultative process amongst pancreatologists from 49 countries. It provides a set of concise up-to-date definitions of all the main entities pertinent to classifying the severity of acute pancreatitis in clinical practice and research. This ensures that the determinant-based classification can be used in a uniform manner throughout the world.",
keywords = "acute pancreatitis, classification, definition, organ failure, pancreatic infectious complications, pancreatic necrosis, peripancreatic necrosis, severity",
author = "Dellinger, {E. Patchen} and Forsmark, {Christopher E.} and Peter Layer and Philippe Levy and Enrique Marav{\'i}-Poma and Petrov, {Maxim S.} and Tooru Shimosegawa and Siriwardena, {Ajith K.} and Generoso Uomo and Whitcomb, {David C.} and Windsor, {John A.} and {Abu Hilal}, M. and Abu-Zidan, {F. M.} and Acosta, {J. M.} and Ainsworth, {A. P.} and {Aizcorbe Garralda}, M. and H. Alagozlu and Al'aref, {S. J.} and {Albeniz Arbizu}, E. and A. Alhajeri and Almeida, {I. C.} and Almeida, {J. L.} and H. Amano and Ammori, {B. J.} and R. Andersson and A. Andr{\'e}n-Sandberg and Ardengh, {J. C.} and Arroyo-Sanchez, {A. S.} and M. Arvanitakis and Ashley, {S. W.} and G. Aygencel and Ayoub, {W. A.} and J. Baillie and M. Bala and Ball, {C. G.} and Baron, {T. H.} and Barreto, {S. G.} and M. Basaranoglu and Beger, {H. G.} and {Bernal Monterde}, V. and N. Bharwani and Bhasin, {D. K.} and Bong, {J. J.} and G. Botoi and T. Bruennler and E. Cairoli and Carter, {C. R.} and D. Cernea and Chari, {Suresh T} and Charnley, {R. M.} and S. Chooklin and D. Cochior and C. Col and Conwell, {D. L.} and Correia, {M. I.} and Z. Dambrauskas and K. Darvas and {De Campos}, T. and {De Casasola}, {G. G.} and {De Waele}, {J. J.} and {Del Chiaro}, M. and {Delle Fave}, G. and Dellinger, {E. P.} and E. De-Madaria and {Di Sebastiano}, P. and Diuzheva, {T. G.} and A. Duarte-Rojo and Fagenholz, {P. J.} and G. Farkas and {Farre Viladrich}, A. and {Fernandezdel Castillo}, C. and Forsmark, {C. E.} and H. Friess and Frossard, {J. L.} and V. Gandhi and Gardner, {T. B.} and B. Gloor and M. Gluk and Goltsov, {V. R.} and J. Guevara-Campos and Gumbs, {A. A.} and T. Hackert and G. Hauser and Horvath, {K. D.} and Howard, {T. J.} and H. Igarashi and O. Ioannidis and S. Jaber and James, {F. E.} and Jha, {R. K.} and D. Juneja and T. Kamisawa and P. Kandasami and M. Kantarcioglu and Kapoor, {V. K.} and T. Karakan and E. Kaya and A. Khaliq and S. Kiriyama and R. Kochhar and Konstantinou, {G. N.} and Kyl{\"a}np{\"a}{\"a}, {M. L.} and Lankisch, {P. G.} and {Laplaza Santos}, C. and J. Lata and P. Layer and A. Lepp{\"a}niemi and P. Levy and A. Lopez and {L{\'o}pez Camps}, V. and Lujano-Nicolas, {L. A.} and H. Lund and D. Lytras and {Macaya Redin}, L. and Machado, {M. C.} and {Macias Rodriguez}, {M. A.} and O. Mann and E. Maravi-Poma and M. Marincas and S. Marwah and E. Mas and Matheus, {A. S.} and R. Meier and D. Mennecier and P. Mentula and A. Mifkovic and R. Mofidi and Mole, {D. J.} and G. Morris-Stiff and J. Mossner and Muftuoglu, {M. A.} and Munsell, {M. A.} and Nathens, {A. B.} and V. Neri and C. N{\"o}jgaard and I. Nordback and C. Ocampo and A. Ol{\'a}h and J. Olejnik and O'Reilly, {D. A.} and A. Oria and J. Panek and Papachristou, {G. I.} and D. Parekh and Parks, {R. W.} and C. Passaglia and Pearce, {C. B.} and D. Pellegrini and M. Perez-Mateo and Petrov, {M. S.} and V. Pettila and R. Pezzilli and Pitchumoni, {C. S.} and S. Pongprasobchai and {Poves Prim}, I. and P. Puolakkainen and G. Pupelis and Radenkovic, {D. V.} and Rahman, {S. H.} and {Regidor Sanz}, E. and A. Repiso and L. Rodrigo and A. Rosseland and G. Rydzewska and {S{\'a}nchez-Izquierdo Riera}, {J. A.} and Savides, {T. J.} and M. Scaglione and A. Serrablo and E. Servin-Torres and I. Sethu and O. Sezgin and M. Shankar-Hari and T. Shimosegawa and Singer, {M. V.} and Sinha, {S. K.} and Siriwardena, {A. K.} and {Sjoberg Bexelius}, T. and Skipworth, {J. R.} and Soriano, {F. G.} and R. Sotoudehmanesh and Spanier, {B. W.} and B. Stabuc and C. Stroescu and Z. Szentkereszty and T. Takacs and T. Takada and K. Takeda and Y. Takeyama and W. Tang and K. Tanjoh and Tarnasky, {P. R.} and N. Teich and Tellado, {J. M.} and S. Tenner and A. Thomson and M. Tireli and Z. Tong and C. Triantopoulou and G. Uomo and Uy, {M. C.} and {Van Geenen}, {E. J.} and {Velasco Guardado}, A. and N. Vettoretto and Vollmer, {C. M.} and K. Wada and Warshaw, {A. L.} and Weinbroum, {A. A.} and Whitcomb, {D. C.} and Wilson, {J. S.} and Windsor, {J. A.} and M. Wittau and Wu, {B. U.} and Wysocki, {A. P.} and {Yan Quiros}, E. and T. Yasuda and C. Yu and E. Zerem and X. Zhou and {Zubia Olazcoaga}, F. and Zyromski, {N. J.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1055/s-0033-1335526",
language = "German",
volume = "51",
pages = "544--550",
journal = "Zeitschrift fur Gastroenterologie",
issn = "0044-2771",
publisher = "Karl Demeter Verlag GmbH",
number = "6",

}

TY - JOUR

T1 - Einteilung des Schweregrads der akuten Pankreatitis

T2 - Internationale, multidisziplinäre klinische Klassifikation auf Basis pathogenetischer Determinanten: Deutsche Version 2013

AU - Dellinger, E. Patchen

AU - Forsmark, Christopher E.

AU - Layer, Peter

AU - Levy, Philippe

AU - Maraví-Poma, Enrique

AU - Petrov, Maxim S.

AU - Shimosegawa, Tooru

AU - Siriwardena, Ajith K.

AU - Uomo, Generoso

AU - Whitcomb, David C.

AU - Windsor, John A.

AU - Abu Hilal, M.

AU - Abu-Zidan, F. M.

AU - Acosta, J. M.

AU - Ainsworth, A. P.

AU - Aizcorbe Garralda, M.

AU - Alagozlu, H.

AU - Al'aref, S. J.

AU - Albeniz Arbizu, E.

AU - Alhajeri, A.

AU - Almeida, I. C.

AU - Almeida, J. L.

AU - Amano, H.

AU - Ammori, B. J.

AU - Andersson, R.

AU - Andrén-Sandberg, A.

AU - Ardengh, J. C.

AU - Arroyo-Sanchez, A. S.

AU - Arvanitakis, M.

AU - Ashley, S. W.

AU - Aygencel, G.

AU - Ayoub, W. A.

AU - Baillie, J.

AU - Bala, M.

AU - Ball, C. G.

AU - Baron, T. H.

AU - Barreto, S. G.

AU - Basaranoglu, M.

AU - Beger, H. G.

AU - Bernal Monterde, V.

AU - Bharwani, N.

AU - Bhasin, D. K.

AU - Bong, J. J.

AU - Botoi, G.

AU - Bruennler, T.

AU - Cairoli, E.

AU - Carter, C. R.

AU - Cernea, D.

AU - Chari, Suresh T

AU - Charnley, R. M.

AU - Chooklin, S.

AU - Cochior, D.

AU - Col, C.

AU - Conwell, D. L.

AU - Correia, M. I.

AU - Dambrauskas, Z.

AU - Darvas, K.

AU - De Campos, T.

AU - De Casasola, G. G.

AU - De Waele, J. J.

AU - Del Chiaro, M.

AU - Delle Fave, G.

AU - Dellinger, E. P.

AU - De-Madaria, E.

AU - Di Sebastiano, P.

AU - Diuzheva, T. G.

AU - Duarte-Rojo, A.

AU - Fagenholz, P. J.

AU - Farkas, G.

AU - Farre Viladrich, A.

AU - Fernandezdel Castillo, C.

AU - Forsmark, C. E.

AU - Friess, H.

AU - Frossard, J. L.

AU - Gandhi, V.

AU - Gardner, T. B.

AU - Gloor, B.

AU - Gluk, M.

AU - Goltsov, V. R.

AU - Guevara-Campos, J.

AU - Gumbs, A. A.

AU - Hackert, T.

AU - Hauser, G.

AU - Horvath, K. D.

AU - Howard, T. J.

AU - Igarashi, H.

AU - Ioannidis, O.

AU - Jaber, S.

AU - James, F. E.

AU - Jha, R. K.

AU - Juneja, D.

AU - Kamisawa, T.

AU - Kandasami, P.

AU - Kantarcioglu, M.

AU - Kapoor, V. K.

AU - Karakan, T.

AU - Kaya, E.

AU - Khaliq, A.

AU - Kiriyama, S.

AU - Kochhar, R.

AU - Konstantinou, G. N.

AU - Kylänpää, M. L.

AU - Lankisch, P. G.

AU - Laplaza Santos, C.

AU - Lata, J.

AU - Layer, P.

AU - Leppäniemi, A.

AU - Levy, P.

AU - Lopez, A.

AU - López Camps, V.

AU - Lujano-Nicolas, L. A.

AU - Lund, H.

AU - Lytras, D.

AU - Macaya Redin, L.

AU - Machado, M. C.

AU - Macias Rodriguez, M. A.

AU - Mann, O.

AU - Maravi-Poma, E.

AU - Marincas, M.

AU - Marwah, S.

AU - Mas, E.

AU - Matheus, A. S.

AU - Meier, R.

AU - Mennecier, D.

AU - Mentula, P.

AU - Mifkovic, A.

AU - Mofidi, R.

AU - Mole, D. J.

AU - Morris-Stiff, G.

AU - Mossner, J.

AU - Muftuoglu, M. A.

AU - Munsell, M. A.

AU - Nathens, A. B.

AU - Neri, V.

AU - Nöjgaard, C.

AU - Nordback, I.

AU - Ocampo, C.

AU - Oláh, A.

AU - Olejnik, J.

AU - O'Reilly, D. A.

AU - Oria, A.

AU - Panek, J.

AU - Papachristou, G. I.

AU - Parekh, D.

AU - Parks, R. W.

AU - Passaglia, C.

AU - Pearce, C. B.

AU - Pellegrini, D.

AU - Perez-Mateo, M.

AU - Petrov, M. S.

AU - Pettila, V.

AU - Pezzilli, R.

AU - Pitchumoni, C. S.

AU - Pongprasobchai, S.

AU - Poves Prim, I.

AU - Puolakkainen, P.

AU - Pupelis, G.

AU - Radenkovic, D. V.

AU - Rahman, S. H.

AU - Regidor Sanz, E.

AU - Repiso, A.

AU - Rodrigo, L.

AU - Rosseland, A.

AU - Rydzewska, G.

AU - Sánchez-Izquierdo Riera, J. A.

AU - Savides, T. J.

AU - Scaglione, M.

AU - Serrablo, A.

AU - Servin-Torres, E.

AU - Sethu, I.

AU - Sezgin, O.

AU - Shankar-Hari, M.

AU - Shimosegawa, T.

AU - Singer, M. V.

AU - Sinha, S. K.

AU - Siriwardena, A. K.

AU - Sjoberg Bexelius, T.

AU - Skipworth, J. R.

AU - Soriano, F. G.

AU - Sotoudehmanesh, R.

AU - Spanier, B. W.

AU - Stabuc, B.

AU - Stroescu, C.

AU - Szentkereszty, Z.

AU - Takacs, T.

AU - Takada, T.

AU - Takeda, K.

AU - Takeyama, Y.

AU - Tang, W.

AU - Tanjoh, K.

AU - Tarnasky, P. R.

AU - Teich, N.

AU - Tellado, J. M.

AU - Tenner, S.

AU - Thomson, A.

AU - Tireli, M.

AU - Tong, Z.

AU - Triantopoulou, C.

AU - Uomo, G.

AU - Uy, M. C.

AU - Van Geenen, E. J.

AU - Velasco Guardado, A.

AU - Vettoretto, N.

AU - Vollmer, C. M.

AU - Wada, K.

AU - Warshaw, A. L.

AU - Weinbroum, A. A.

AU - Whitcomb, D. C.

AU - Wilson, J. S.

AU - Windsor, J. A.

AU - Wittau, M.

AU - Wu, B. U.

AU - Wysocki, A. P.

AU - Yan Quiros, E.

AU - Yasuda, T.

AU - Yu, C.

AU - Zerem, E.

AU - Zhou, X.

AU - Zubia Olazcoaga, F.

AU - Zyromski, N. J.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective: To develop a new classification of acute pancreatitis severity on the basis of a sound conceptual framework, comprehensive review of published evidence, and worldwide consultation. Background: The Atlanta definitions of acute pancreatitis severity are ingrained in the lexicon of pancreatologists but suboptimal because these definitions are based on empiric description of occurrences that are merely associated with severity. Methods: A personal invitation to contribute to the development of a new classification of acute pancreatitis severity was sent to all surgeons, gastroen-terologists, internists, intensivists, and radiologists who are currently active in clinical research on acute pancreatitis. The invitation was not limited to members of certain associations or residents of certain countries. A global Web-based survey was conducted and a dedicated international symposium was organized to bring contributors from different disciplines together and discuss the concept and definitions. Result: The new classification of severity is based on the actual local and systemic determinants of severity, rather than description of events that are correlated with severity. The local determinant relates to whether there is (peri)pancreatic necrosis or not, and if present, whether it is sterile or infected. The systemic determinant relates to whether there is organ failure or not, and if present, whether it is transient or persistent. The presence of one determinant can modify the effect of another such that the presence of both infected (peri)pancreatic necrosis and persistent organ failure have a greater effect on severity than either determinant alone. The derivation of a classification based on the above principles results in 4 categories of severity-mild, moderate, severe, and critical. Conclusions: This classification is the result of a consultative process amongst pancreatologists from 49 countries. It provides a set of concise up-to-date definitions of all the main entities pertinent to classifying the severity of acute pancreatitis in clinical practice and research. This ensures that the determinant-based classification can be used in a uniform manner throughout the world.

AB - Objective: To develop a new classification of acute pancreatitis severity on the basis of a sound conceptual framework, comprehensive review of published evidence, and worldwide consultation. Background: The Atlanta definitions of acute pancreatitis severity are ingrained in the lexicon of pancreatologists but suboptimal because these definitions are based on empiric description of occurrences that are merely associated with severity. Methods: A personal invitation to contribute to the development of a new classification of acute pancreatitis severity was sent to all surgeons, gastroen-terologists, internists, intensivists, and radiologists who are currently active in clinical research on acute pancreatitis. The invitation was not limited to members of certain associations or residents of certain countries. A global Web-based survey was conducted and a dedicated international symposium was organized to bring contributors from different disciplines together and discuss the concept and definitions. Result: The new classification of severity is based on the actual local and systemic determinants of severity, rather than description of events that are correlated with severity. The local determinant relates to whether there is (peri)pancreatic necrosis or not, and if present, whether it is sterile or infected. The systemic determinant relates to whether there is organ failure or not, and if present, whether it is transient or persistent. The presence of one determinant can modify the effect of another such that the presence of both infected (peri)pancreatic necrosis and persistent organ failure have a greater effect on severity than either determinant alone. The derivation of a classification based on the above principles results in 4 categories of severity-mild, moderate, severe, and critical. Conclusions: This classification is the result of a consultative process amongst pancreatologists from 49 countries. It provides a set of concise up-to-date definitions of all the main entities pertinent to classifying the severity of acute pancreatitis in clinical practice and research. This ensures that the determinant-based classification can be used in a uniform manner throughout the world.

KW - acute pancreatitis

KW - classification

KW - definition

KW - organ failure

KW - pancreatic infectious complications

KW - pancreatic necrosis

KW - peripancreatic necrosis

KW - severity

UR - http://www.scopus.com/inward/record.url?scp=84878778600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878778600&partnerID=8YFLogxK

U2 - 10.1055/s-0033-1335526

DO - 10.1055/s-0033-1335526

M3 - Article

C2 - 23740353

AN - SCOPUS:84878778600

VL - 51

SP - 544

EP - 550

JO - Zeitschrift fur Gastroenterologie

JF - Zeitschrift fur Gastroenterologie

SN - 0044-2771

IS - 6

ER -