Detection of simultaneous β-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection

Raymund R Razonable, Antonio Rivero, Robert A. Brown, Gregory D. Hart, Mark J. Espy, Hester van Cruijsen, Jennie Wilson, Cynthia Groettum, Walter K Kremers, Thomas F. Smith, Carlos V. Paya

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Human herpesvirus (HHV)-6 and HHV-7 are increasingly being recognized as emerging pathogens among transplant recipients. Using quantitative polymerase chain reaction assays, we demonstrate the presence of HHV-6 and/or HHV-7 in 18 of 20 episodes of clinically presumed or microbiologically confirmed cytomegalovirus (CMV) infection. Seventeen (89%) of 19 microbiologically confirmed cytomegalovirus (CMV)-infected patients had concomitant HHV-6 variant B (47%) and/or HHV-7 (63%) infection. The degree of HHV-6 coinfection was significantly correlated with hyperbilirubinemia while HHV-7 coinfection demonstrated a non-significant trend toward cytopenias. In one of the 20 episodes described herein, the 'viral syndrome' was due solely to HHV-7 infection; clinical and virological response was observed during intravenous ganciclovir therapy in this patient. While this study emphasizes the significance of HHV-6 and/or HHV-7 coinfection during episodes of CMV infection, it significantly highlights the novel observation of the causal role of HHV-7 (in the absence of HHV-6 and CMV) in a clinical illness presumed to be caused CMV. Thus, HHV-7 (and HHV-6) should be considered as a pathogen (or copathogen) in the viral syndromes following organ transplantation.

Original languageEnglish (US)
Pages (from-to)114-120
Number of pages7
JournalClinical Transplantation
Volume17
Issue number2
DOIs
StatePublished - Apr 2003

Fingerprint

Human Herpesvirus 7
Herpesviridae Infections
Human Herpesvirus 6
Cytomegalovirus Infections
Cytomegalovirus
Coinfection
Ganciclovir
Hyperbilirubinemia
Organ Transplantation
Observation
Polymerase Chain Reaction

Keywords

  • Cytomegalovirus
  • Human herpesvirus-6
  • Human herpesvirus-7
  • Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Detection of simultaneous β-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection. / Razonable, Raymund R; Rivero, Antonio; Brown, Robert A.; Hart, Gregory D.; Espy, Mark J.; van Cruijsen, Hester; Wilson, Jennie; Groettum, Cynthia; Kremers, Walter K; Smith, Thomas F.; Paya, Carlos V.

In: Clinical Transplantation, Vol. 17, No. 2, 04.2003, p. 114-120.

Research output: Contribution to journalArticle

Razonable, RR, Rivero, A, Brown, RA, Hart, GD, Espy, MJ, van Cruijsen, H, Wilson, J, Groettum, C, Kremers, WK, Smith, TF & Paya, CV 2003, 'Detection of simultaneous β-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection', Clinical Transplantation, vol. 17, no. 2, pp. 114-120. https://doi.org/10.1034/j.1399-0012.2003.02104.x
Razonable, Raymund R ; Rivero, Antonio ; Brown, Robert A. ; Hart, Gregory D. ; Espy, Mark J. ; van Cruijsen, Hester ; Wilson, Jennie ; Groettum, Cynthia ; Kremers, Walter K ; Smith, Thomas F. ; Paya, Carlos V. / Detection of simultaneous β-herpesvirus infections in clinical syndromes due to defined cytomegalovirus infection. In: Clinical Transplantation. 2003 ; Vol. 17, No. 2. pp. 114-120.
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