Detection of Progressive Myocardial Tissue Injury by Ultrasonic Integrated Backscatter Immediately After Coronary Reperfusion

Minako Katayama, Panupong Jiamsripong, Eileen M. McMahon, Theresa R. Lombari, Anna E. Bukatina, Qing Wu, Ronald J. Marler, Marek Belohlavek

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Myocardial reperfusion following ischemia may paradoxically cause additional injury, including microvascular damage and edema. These structural alterations augment tissue echogenicity, which is measurable by ultrasonic integrated backscatter (IB). We sought to characterize alterations in myocardial IB in an ischemic and reperfused region of the rat heart. Myocardial IB of the regions of interest in 12 adult male Sprague-Dawley rats was studied at baseline, during ischemia, and chronologically after coronary reopening, using an ultrasound frequency of 8 MHz. IB did not significantly change between baseline and ischemia. However, within 1 min of reperfusion, IB significantly increased and continued to increase until 10 min of reperfusion, when a plateau was reached. Areas of high echogenicity were comparable to infarcted areas on gross pathologic slices and had edema with extravasation of red blood cells. Myocardial reperfusion following ischemia significantly augments tissue echogenicity. A continuing increase of IB suggests a rapid progression of reperfusion injury.

Original languageEnglish (US)
Pages (from-to)1662-1669
Number of pages8
JournalUltrasound in Medicine and Biology
Volume38
Issue number9
DOIs
StatePublished - Sep 2012

Keywords

  • Acute myocardial infarction
  • Integrated backscatter
  • Myocardial edema
  • Reperfusion injury
  • Ultrasound tissue characterization

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

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