Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma

Thomas E. Witzig; Morie A. Gertz; Alvaro A. Pineda; Robert A. Kyle; Philip R. Greipp

doi:10.1111/j.1365-2141.1995.tb08378.x

Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma

Thomas E. Witzig, Morie A. Gertz, Alvaro A. Pineda, Robert A. Kyle, Philip R. Greipp

Hematology

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

We evaluated the harvest product from 47 patients undergoing peripheral blood (BP) stem cell collections for monoclonal plasma cells (PC) using a sensitive immunofluorescence technique. 60% (28/47) had docu mented tumour cells in the apheresis product. The 32 patients in plateau had a mean of 1.62 x 10⁶ PC/1 v 74.64 x 10⁶ in 15 relapsed patients (P < 0.01). 32% (6/19) of patients without any tumour cells in the initial sample had them detected on a subsequent apheresis sample. In four cases (all treated with GM‐CSF) small numbers of tumour cells were detected initially but became undetectable on a subsequent sample.

Original language	English (US)
Pages (from-to)	640-642
Number of pages	3
Journal	British journal of haematology
Volume	89
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.1995.tb08378.x
State	Published - Mar 1995

Keywords

autologous transplant
multiple myeloma
stem cells

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.1995.tb08378.x

Cite this

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title = "Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma",

abstract = "We evaluated the harvest product from 47 patients undergoing peripheral blood (BP) stem cell collections for monoclonal plasma cells (PC) using a sensitive immunofluorescence technique. 60% (28/47) had docu mented tumour cells in the apheresis product. The 32 patients in plateau had a mean of 1.62 x 106 PC/1 v 74.64 x 106 in 15 relapsed patients (P < 0.01). 32% (6/19) of patients without any tumour cells in the initial sample had them detected on a subsequent apheresis sample. In four cases (all treated with GM‐CSF) small numbers of tumour cells were detected initially but became undetectable on a subsequent sample.",

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AU - Gertz, Morie A.

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AU - Kyle, Robert A.

AU - Greipp, Philip R.

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Detection of monoclonal plasma cells in the peripheral blood stem cell harvests of patients with multiple myeloma

Abstract

Keywords

ASJC Scopus subject areas

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