Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis

Edwin A. McElroy, Thomas E. Witzig, Morie A. Gertz, Philip R. Greippand, Roberta Kyle

Research output: Contribution to journalArticle

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Abstract

We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal BPC were detected in 16% (24/150) of patients. The median number of monoclonal BPC was 1 x 106/l and 4.6% (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood of patients with AL-amyloidosis.

Original languageEnglish (US)
Pages (from-to)326-327
Number of pages2
JournalBritish journal of haematology
Volume100
Issue number2
DOIs
StatePublished - Apr 2 1998

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Keywords

  • Amyloidosis
  • Labelling index
  • Plasma cells

ASJC Scopus subject areas

  • Hematology

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