Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis

Edwin A. McElroy, Thomas Elmer Witzig, Morie Gertz, Philip R. Greippand, Roberta Kyle

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal BPC were detected in 16% (24/150) of patients. The median number of monoclonal BPC was 1 x 10 6/l and 4.6% (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood of patients with AL-amyloidosis.

Original languageEnglish (US)
Pages (from-to)326-327
Number of pages2
JournalBritish Journal of Haematology
Volume100
Issue number2
DOIs
StatePublished - 1998

Fingerprint

Plasma Cells
Blood Cells
Bromodeoxyuridine
Amyloidosis
S Phase
Fluorescent Antibody Technique
Primary amyloidosis

Keywords

  • Amyloidosis
  • Labelling index
  • Plasma cells

ASJC Scopus subject areas

  • Hematology

Cite this

Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis. / McElroy, Edwin A.; Witzig, Thomas Elmer; Gertz, Morie; Greippand, Philip R.; Kyle, Roberta.

In: British Journal of Haematology, Vol. 100, No. 2, 1998, p. 326-327.

Research output: Contribution to journalArticle

@article{964d08e639d443dba75ea2cb321aa4f5,
title = "Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis",
abstract = "We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal BPC were detected in 16{\%} (24/150) of patients. The median number of monoclonal BPC was 1 x 10 6/l and 4.6{\%} (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood of patients with AL-amyloidosis.",
keywords = "Amyloidosis, Labelling index, Plasma cells",
author = "McElroy, {Edwin A.} and Witzig, {Thomas Elmer} and Morie Gertz and Greippand, {Philip R.} and Roberta Kyle",
year = "1998",
doi = "10.1046/j.1365-2141.1998.00583.x",
language = "English (US)",
volume = "100",
pages = "326--327",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis

AU - McElroy, Edwin A.

AU - Witzig, Thomas Elmer

AU - Gertz, Morie

AU - Greippand, Philip R.

AU - Kyle, Roberta

PY - 1998

Y1 - 1998

N2 - We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal BPC were detected in 16% (24/150) of patients. The median number of monoclonal BPC was 1 x 10 6/l and 4.6% (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood of patients with AL-amyloidosis.

AB - We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal BPC were detected in 16% (24/150) of patients. The median number of monoclonal BPC was 1 x 10 6/l and 4.6% (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood of patients with AL-amyloidosis.

KW - Amyloidosis

KW - Labelling index

KW - Plasma cells

UR - http://www.scopus.com/inward/record.url?scp=6844250766&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6844250766&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.1998.00583.x

DO - 10.1046/j.1365-2141.1998.00583.x

M3 - Article

VL - 100

SP - 326

EP - 327

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -