Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis

Edwin A. McElroy; Thomas E. Witzig; Morie A. Gertz; Philip R. Greippand; Roberta Kyle

doi:10.1046/j.1365-2141.1998.00583.x

Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis

Edwin A. McElroy, Thomas E. Witzig, Morie A. Gertz, Philip R. Greippand, Roberta Kyle

Hematology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal BPC were detected in 16% (24/150) of patients. The median number of monoclonal BPC was 1 x 10⁶/l and 4.6% (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood of patients with AL-amyloidosis.

Original language	English (US)
Pages (from-to)	326-327
Number of pages	2
Journal	British journal of haematology
Volume	100
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.1998.00583.x
State	Published - 1998

Keywords

Amyloidosis
Labelling index
Plasma cells

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.1998.00583.x

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title = "Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis",

abstract = "We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal BPC were detected in 16% (24/150) of patients. The median number of monoclonal BPC was 1 x 106/l and 4.6% (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood of patients with AL-amyloidosis.",

keywords = "Amyloidosis, Labelling index, Plasma cells",

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T1 - Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis

AU - McElroy, Edwin A.

AU - Witzig, Thomas E.

AU - Gertz, Morie A.

AU - Greippand, Philip R.

AU - Kyle, Roberta

PY - 1998

Y1 - 1998

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AB - We evaluated the blood from 150 patients with primary AL-amyloidosis for circulating monoclonal plasma cells using a sensitive slide-based immunofluorescence technique. The percentage of monoclonal blood plasma cells (BPC) that were in S-phase was determined by the bromodeoxyuridine labelling index (BLI). Monoclonal BPC were detected in 16% (24/150) of patients. The median number of monoclonal BPC was 1 x 106/l and 4.6% (7/150) of patients had a high number. The BLI was zero in all but three patients. This study demonstrates that monoclonal plasma cells circulate in the peripheral blood of patients with AL-amyloidosis.

KW - Amyloidosis

KW - Labelling index

KW - Plasma cells

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Detection of monoclonal plasma cells in the peripheral blood of patients with primary amyloidosis

Abstract

Keywords

ASJC Scopus subject areas

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