Detection of JC virus by polymerase chain reaction in cerebrospinal fluid from two patients with progressive multifocal leukoencephalopathy

A. Telenti, W. F. Marshall, Allen Jr. Aksamit, J. D. Smilack, T. F. Smith

Research output: Contribution to journalArticle

26 Scopus citations


The polymerase chain reaction (PCR) was used to identify JC virus (JCV) in the cerebrospinal fluid of two patients with progressive multifocal leukoencephalopathy confirmed by brain biopsy. In addition, JCV viremia was demonstrated by PCR in one case. JCV detection in spinal fluid by PCR may be the first non-invasive technique available for the diagnostic confirmation of progressive multifocal leukoencephalopathy.

Original languageEnglish (US)
Pages (from-to)253-254
Number of pages2
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Issue number3
StatePublished - Mar 1 1992


ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this