Abstract
Multicolour fluorescence in situ hybridization (M-FISH) simultaneously detects all 24 human chromosomes in unique fluorescent colours. The identification of diagnostically critical gene rearrangement(s) in complex karyotypes of haematological disorders continues to be a challenge. We present five cases in which t(9;11), complex t(8;22), t(12;21) and t(11;14) were detected primarily using M-FISH and were confirmed using locus-specific probes. We conclude that M-FISH can be effective in complete characterization of critical gene rearrangements in haematological disorders.
Original language | English (US) |
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Pages (from-to) | 975-980 |
Number of pages | 6 |
Journal | British journal of haematology |
Volume | 112 |
Issue number | 4 |
DOIs | |
State | Published - 2001 |
Keywords
- Complex karyotype
- Critical rearrangement
- Haematological
- M-FISH
ASJC Scopus subject areas
- Hematology