Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation

Eric C. Ehman; Andrew S. Phelps; Michael A. Ohliger; Sue J. Rhee; John D. MacKenzie; Jesse L. Courtier

doi:10.1016/j.clinimag.2016.07.006

Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation

Eric C. Ehman, Andrew S. Phelps, Michael A. Ohliger, Sue J. Rhee, John D. MacKenzie, Jesse L. Courtier

Radiology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Purpose To evaluate the fused, colorized diffusion weighted imaging (DWI) and anatomic T2 images compared to routine contrast-enhanced T1 images at pediatric magnetic resonance enterography (MRE). Methods Fused, colorized DWI/T2 images were created from patients with magnetic resonance enterography (MRE) and colonoscopy/biopsy. Radiologists noted inflammation in five bowel segments (terminal ileum–rectosigmoid colon) on postcontrast images and DWI/T2 images. Test characteristics and agreement were calculated. Results For 20 patients, sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 0.53/0.90/0.77/0.76 for DWI/T2 and 0.45/0.90/0.72/0.73 for postcontrast images. Intraobserver agreement was ҡ=0.45–0.73. Interobserver agreement was ҡ=0.53 for DWI/T2 and ҡ=0.63 for postcontrast images. Conclusion DWI/T2 images are similar in sensitivity/specificity to contrast-enhanced images and with moderate intra/interobserver reliability.

Original language	English (US)
Pages (from-to)	1135-1139
Number of pages	5
Journal	Clinical Imaging
Volume	40
Issue number	6
DOIs	https://doi.org/10.1016/j.clinimag.2016.07.006
State	Published - Nov 1 2016

Keywords

Diffusion-weighted imaging
Enterography
MRI
Pediatric

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/j.clinimag.2016.07.006

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title = "Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation",

abstract = "Purpose To evaluate the fused, colorized diffusion weighted imaging (DWI) and anatomic T2 images compared to routine contrast-enhanced T1 images at pediatric magnetic resonance enterography (MRE). Methods Fused, colorized DWI/T2 images were created from patients with magnetic resonance enterography (MRE) and colonoscopy/biopsy. Radiologists noted inflammation in five bowel segments (terminal ileum–rectosigmoid colon) on postcontrast images and DWI/T2 images. Test characteristics and agreement were calculated. Results For 20 patients, sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 0.53/0.90/0.77/0.76 for DWI/T2 and 0.45/0.90/0.72/0.73 for postcontrast images. Intraobserver agreement was ҡ=0.45–0.73. Interobserver agreement was ҡ=0.53 for DWI/T2 and ҡ=0.63 for postcontrast images. Conclusion DWI/T2 images are similar in sensitivity/specificity to contrast-enhanced images and with moderate intra/interobserver reliability.",

keywords = "Diffusion-weighted imaging, Enterography, MRI, Pediatric",

author = "Ehman, {Eric C.} and Phelps, {Andrew S.} and Ohliger, {Michael A.} and Rhee, {Sue J.} and MacKenzie, {John D.} and Courtier, {Jesse L.}",

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doi = "10.1016/j.clinimag.2016.07.006",

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T1 - Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation

AU - Ehman, Eric C.

AU - Phelps, Andrew S.

AU - Ohliger, Michael A.

AU - Rhee, Sue J.

AU - MacKenzie, John D.

AU - Courtier, Jesse L.

PY - 2016/11/1

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N2 - Purpose To evaluate the fused, colorized diffusion weighted imaging (DWI) and anatomic T2 images compared to routine contrast-enhanced T1 images at pediatric magnetic resonance enterography (MRE). Methods Fused, colorized DWI/T2 images were created from patients with magnetic resonance enterography (MRE) and colonoscopy/biopsy. Radiologists noted inflammation in five bowel segments (terminal ileum–rectosigmoid colon) on postcontrast images and DWI/T2 images. Test characteristics and agreement were calculated. Results For 20 patients, sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 0.53/0.90/0.77/0.76 for DWI/T2 and 0.45/0.90/0.72/0.73 for postcontrast images. Intraobserver agreement was ҡ=0.45–0.73. Interobserver agreement was ҡ=0.53 for DWI/T2 and ҡ=0.63 for postcontrast images. Conclusion DWI/T2 images are similar in sensitivity/specificity to contrast-enhanced images and with moderate intra/interobserver reliability.

AB - Purpose To evaluate the fused, colorized diffusion weighted imaging (DWI) and anatomic T2 images compared to routine contrast-enhanced T1 images at pediatric magnetic resonance enterography (MRE). Methods Fused, colorized DWI/T2 images were created from patients with magnetic resonance enterography (MRE) and colonoscopy/biopsy. Radiologists noted inflammation in five bowel segments (terminal ileum–rectosigmoid colon) on postcontrast images and DWI/T2 images. Test characteristics and agreement were calculated. Results For 20 patients, sensitivity/specificity/positive predictive value (PPV)/negative predictive value (NPV) were 0.53/0.90/0.77/0.76 for DWI/T2 and 0.45/0.90/0.72/0.73 for postcontrast images. Intraobserver agreement was ҡ=0.45–0.73. Interobserver agreement was ҡ=0.53 for DWI/T2 and ҡ=0.63 for postcontrast images. Conclusion DWI/T2 images are similar in sensitivity/specificity to contrast-enhanced images and with moderate intra/interobserver reliability.

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KW - Enterography

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Detection of bowel inflammation with fused DWI/T2 images versus contrast-enhanced images in pediatric MR enterography with histopathologic correlation

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