Detection of antibodies directed at M. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer

Cydney Urbanek, Steven Goodison, Myron Chang, Stacy Porvasnik, Noburo Sakamoto, Chen Zhong Li, Susan K. Boehlein, Charles J. Rosser

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Recent epidemiologic, genetic, and molecular studies suggest infection and inflammation initiate certain cancers, including cancers of the prostate. Over the past several years, our group has been studying how mycoplasmas could possibly initiate and propagate cancers of the prostate. Specifically, Mycoplasma hyorhinis encoded protein p37 was found to promote invasion of prostate cancer cells and cause changes in growth, morphology and gene expression of these cells to a more aggressive phenotype. Moreover, we found that chronic exposure of benign human prostate cells to M. hyorhinis resulted in significant phenotypic and karyotypic changes that ultimately resulted in the malignant transformation of the benign cells. In this study, we set out to investigate another potential link between mycoplasma and human prostate cancer.Methods: We report the incidence of men with prostate cancer and benign prostatic hyperplasia (BPH) being seropositive for M. hyorhinis. Antibodies to M. hyorhinis were surveyed by a novel indirect enzyme-linked immunosorbent assay (ELISA) in serum samples collected from men presenting to an outpatient Urology clinic for BPH (N = 105) or prostate cancer (N = 114) from 2006-2009.Results: A seropositive rate of 36% in men with BPH and 52% in men with prostate cancer was reported, thus leading us to speculate a possible connection between M. hyorhinis exposure with prostate cancer.Conclusions: These results further support a potential exacerbating role for mycoplasma in the development of prostate cancer.

Original languageEnglish (US)
Article number233
JournalBMC Cancer
Volume11
DOIs
StatePublished - Jun 10 2011
Externally publishedYes

Fingerprint

Mycoplasma hyorhinis
Prostatic Neoplasms
Antibodies
Serum
Mycoplasma
Prostatic Hyperplasia
Urology
Ambulatory Care Facilities
Prostate
Molecular Biology
Enzyme-Linked Immunosorbent Assay
Inflammation
Phenotype
Gene Expression
Incidence
Growth
Infection
Neoplasms

Keywords

  • Cancer
  • ELISA
  • Mycoplasma hyorhinis
  • Prostate

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Detection of antibodies directed at M. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer. / Urbanek, Cydney; Goodison, Steven; Chang, Myron; Porvasnik, Stacy; Sakamoto, Noburo; Li, Chen Zhong; Boehlein, Susan K.; Rosser, Charles J.

In: BMC Cancer, Vol. 11, 233, 10.06.2011.

Research output: Contribution to journalArticle

Urbanek, Cydney ; Goodison, Steven ; Chang, Myron ; Porvasnik, Stacy ; Sakamoto, Noburo ; Li, Chen Zhong ; Boehlein, Susan K. ; Rosser, Charles J. / Detection of antibodies directed at M. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer. In: BMC Cancer. 2011 ; Vol. 11.
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