Detecting clinical change with the CDR-FTLD: Differences between FTLD and AD dementia

Eneida Mioshi, Emma Flanagan, David S Knopman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To investigate the psychometric properties of the Clinical Dementia Scale-frontotemporal lobar degeneration (CDR-FTLD) psychometric properties using Rasch analysis and its sensitivity distinguishing disease progression between FTLD and Alzheimer's disease (AD). Methods: Of 603 consecutive patients from the National Alzheimer Coordinating Center dataset (FTLD=350; AD=253), 120 FTLDs were included in a Rasch analysis to verify CDR-FTLD psychometric properties; 483 (FTLD=230; AD=253) were included to analyse disease progression, with 195 (FTLD=82; AD=113) followed-up (24months). Results: The CDR-FTLD demonstrated good consistency, construct and concurrent validity and correlated well with mini-mental state examination (MMSE) and disease duration (ps<0.05). At baseline, FTLD showed greater dementia severity than AD after matched for MMSE and disease duration (p<0.001). Independent Rasch analyses demonstrated different patterns of progression for FTLD and AD in terms of the domains initially and then subsequently affected with disease progression. At follow-up, although MMSE showed significant changes (p<0.05), these were greater on the CDR-FTLD (p<0.001). Conclusion: The CDR-FTLD satisfactorily measures dementia severity and change in FTLD, distinguishing disease progression between FTLD and AD, with clear implications for care, prognosis and future clinical trials.

Original languageEnglish (US)
JournalInternational Journal of Geriatric Psychiatry
DOIs
StateAccepted/In press - 2016

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Frontotemporal Lobar Degeneration
Alzheimer Disease
Disease Progression
Psychometrics
Dementia

Keywords

  • CDR-FTLD
  • Dementia severity
  • Disease progression
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

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title = "Detecting clinical change with the CDR-FTLD: Differences between FTLD and AD dementia",
abstract = "Objective: To investigate the psychometric properties of the Clinical Dementia Scale-frontotemporal lobar degeneration (CDR-FTLD) psychometric properties using Rasch analysis and its sensitivity distinguishing disease progression between FTLD and Alzheimer's disease (AD). Methods: Of 603 consecutive patients from the National Alzheimer Coordinating Center dataset (FTLD=350; AD=253), 120 FTLDs were included in a Rasch analysis to verify CDR-FTLD psychometric properties; 483 (FTLD=230; AD=253) were included to analyse disease progression, with 195 (FTLD=82; AD=113) followed-up (24months). Results: The CDR-FTLD demonstrated good consistency, construct and concurrent validity and correlated well with mini-mental state examination (MMSE) and disease duration (ps<0.05). At baseline, FTLD showed greater dementia severity than AD after matched for MMSE and disease duration (p<0.001). Independent Rasch analyses demonstrated different patterns of progression for FTLD and AD in terms of the domains initially and then subsequently affected with disease progression. At follow-up, although MMSE showed significant changes (p<0.05), these were greater on the CDR-FTLD (p<0.001). Conclusion: The CDR-FTLD satisfactorily measures dementia severity and change in FTLD, distinguishing disease progression between FTLD and AD, with clear implications for care, prognosis and future clinical trials.",
keywords = "CDR-FTLD, Dementia severity, Disease progression, Frontotemporal dementia, Frontotemporal lobar degeneration",
author = "Eneida Mioshi and Emma Flanagan and Knopman, {David S}",
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language = "English (US)",
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AU - Mioshi, Eneida

AU - Flanagan, Emma

AU - Knopman, David S

PY - 2016

Y1 - 2016

N2 - Objective: To investigate the psychometric properties of the Clinical Dementia Scale-frontotemporal lobar degeneration (CDR-FTLD) psychometric properties using Rasch analysis and its sensitivity distinguishing disease progression between FTLD and Alzheimer's disease (AD). Methods: Of 603 consecutive patients from the National Alzheimer Coordinating Center dataset (FTLD=350; AD=253), 120 FTLDs were included in a Rasch analysis to verify CDR-FTLD psychometric properties; 483 (FTLD=230; AD=253) were included to analyse disease progression, with 195 (FTLD=82; AD=113) followed-up (24months). Results: The CDR-FTLD demonstrated good consistency, construct and concurrent validity and correlated well with mini-mental state examination (MMSE) and disease duration (ps<0.05). At baseline, FTLD showed greater dementia severity than AD after matched for MMSE and disease duration (p<0.001). Independent Rasch analyses demonstrated different patterns of progression for FTLD and AD in terms of the domains initially and then subsequently affected with disease progression. At follow-up, although MMSE showed significant changes (p<0.05), these were greater on the CDR-FTLD (p<0.001). Conclusion: The CDR-FTLD satisfactorily measures dementia severity and change in FTLD, distinguishing disease progression between FTLD and AD, with clear implications for care, prognosis and future clinical trials.

AB - Objective: To investigate the psychometric properties of the Clinical Dementia Scale-frontotemporal lobar degeneration (CDR-FTLD) psychometric properties using Rasch analysis and its sensitivity distinguishing disease progression between FTLD and Alzheimer's disease (AD). Methods: Of 603 consecutive patients from the National Alzheimer Coordinating Center dataset (FTLD=350; AD=253), 120 FTLDs were included in a Rasch analysis to verify CDR-FTLD psychometric properties; 483 (FTLD=230; AD=253) were included to analyse disease progression, with 195 (FTLD=82; AD=113) followed-up (24months). Results: The CDR-FTLD demonstrated good consistency, construct and concurrent validity and correlated well with mini-mental state examination (MMSE) and disease duration (ps<0.05). At baseline, FTLD showed greater dementia severity than AD after matched for MMSE and disease duration (p<0.001). Independent Rasch analyses demonstrated different patterns of progression for FTLD and AD in terms of the domains initially and then subsequently affected with disease progression. At follow-up, although MMSE showed significant changes (p<0.05), these were greater on the CDR-FTLD (p<0.001). Conclusion: The CDR-FTLD satisfactorily measures dementia severity and change in FTLD, distinguishing disease progression between FTLD and AD, with clear implications for care, prognosis and future clinical trials.

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