Detailed analysis of the radiographic presentation of Mycobacterium kansasii lung disease in patients with HIV infection

Adithya Cattamanchi, Payam Nahid, Theodore K. Marras, Michael Gotway, Theodore J. Lee, Leah C. Gonzalez, Alison Morris, W. Richard Webb, Dennis H. Osmond, Charles L. Daley

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Published criteria for the diagnosis of Mycobacterium kansasii lung disease require the presence of clinical symptoms, positive microbiologic results, and radiographic abnormalities. In patients with HIV infection, the radiographic findings of M kansasii lung disease are not well described. Methods: Medical records and chest radiographs of all patients with HIV infection and at least one respiratory specimen culture positive for M kansasii at San Francisco General Hospital between December 1989 and July 2002 were reviewed. Results: Chest radiographic results were abnormal in 75 of 83 patients (90%) included in the study. Radiographic abnormalities were diverse, with consolidation (66%) and nodules (42%) as the most frequent findings. The mid or lower lung zones were involved in 89% of patients. The pattern of radiographic abnormalities did not differ based on acid-fast bacilli smear status, the presence or absence of coexisting pulmonary infections, or CD4+ T-lymphocyte count. In multivariate Cox regression analysis, cavitation was the only radiographic abnormality independently associated with mortality (hazard ratio, 4.8; 95% confidence interval, 1.2 to 19.6). Conclusion: Patients with HIV infection and M kansasii lung disease present with diverse radiographic patterns, most commonly consolidation and nodules predominantly located in the mid and lower lung zones. This finding is in contrast to the upper-lobe cavitary presentation described in patients without HIV infection. Although rare, the presence of cavitary disease in patients with HIV infection and M kansasii independently predicts worse outcome. The diversity in the radiographic presentation of M kansasii lung disease implies that clinicians should obtain sputum mycobacterial culture samples from any patient with HIV infection and an abnormal chest radiograph finding.

Original languageEnglish (US)
Pages (from-to)875-880
Number of pages6
JournalChest
Volume133
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Mycobacterium kansasii
Lung Diseases
HIV Infections
Thorax
Lung
San Francisco
CD4 Lymphocyte Count
Sputum
General Hospitals
Bacillus
Medical Records
Regression Analysis
Confidence Intervals
T-Lymphocytes
Acids

Keywords

  • Atypical
  • HIV
  • Mycobacteria
  • Mycobacterium kansasii
  • Radiography

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Cattamanchi, A., Nahid, P., Marras, T. K., Gotway, M., Lee, T. J., Gonzalez, L. C., ... Daley, C. L. (2008). Detailed analysis of the radiographic presentation of Mycobacterium kansasii lung disease in patients with HIV infection. Chest, 133(4), 875-880. https://doi.org/10.1378/chest.07-2171

Detailed analysis of the radiographic presentation of Mycobacterium kansasii lung disease in patients with HIV infection. / Cattamanchi, Adithya; Nahid, Payam; Marras, Theodore K.; Gotway, Michael; Lee, Theodore J.; Gonzalez, Leah C.; Morris, Alison; Webb, W. Richard; Osmond, Dennis H.; Daley, Charles L.

In: Chest, Vol. 133, No. 4, 04.2008, p. 875-880.

Research output: Contribution to journalArticle

Cattamanchi, A, Nahid, P, Marras, TK, Gotway, M, Lee, TJ, Gonzalez, LC, Morris, A, Webb, WR, Osmond, DH & Daley, CL 2008, 'Detailed analysis of the radiographic presentation of Mycobacterium kansasii lung disease in patients with HIV infection', Chest, vol. 133, no. 4, pp. 875-880. https://doi.org/10.1378/chest.07-2171
Cattamanchi, Adithya ; Nahid, Payam ; Marras, Theodore K. ; Gotway, Michael ; Lee, Theodore J. ; Gonzalez, Leah C. ; Morris, Alison ; Webb, W. Richard ; Osmond, Dennis H. ; Daley, Charles L. / Detailed analysis of the radiographic presentation of Mycobacterium kansasii lung disease in patients with HIV infection. In: Chest. 2008 ; Vol. 133, No. 4. pp. 875-880.
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abstract = "Background: Published criteria for the diagnosis of Mycobacterium kansasii lung disease require the presence of clinical symptoms, positive microbiologic results, and radiographic abnormalities. In patients with HIV infection, the radiographic findings of M kansasii lung disease are not well described. Methods: Medical records and chest radiographs of all patients with HIV infection and at least one respiratory specimen culture positive for M kansasii at San Francisco General Hospital between December 1989 and July 2002 were reviewed. Results: Chest radiographic results were abnormal in 75 of 83 patients (90{\%}) included in the study. Radiographic abnormalities were diverse, with consolidation (66{\%}) and nodules (42{\%}) as the most frequent findings. The mid or lower lung zones were involved in 89{\%} of patients. The pattern of radiographic abnormalities did not differ based on acid-fast bacilli smear status, the presence or absence of coexisting pulmonary infections, or CD4+ T-lymphocyte count. In multivariate Cox regression analysis, cavitation was the only radiographic abnormality independently associated with mortality (hazard ratio, 4.8; 95{\%} confidence interval, 1.2 to 19.6). Conclusion: Patients with HIV infection and M kansasii lung disease present with diverse radiographic patterns, most commonly consolidation and nodules predominantly located in the mid and lower lung zones. This finding is in contrast to the upper-lobe cavitary presentation described in patients without HIV infection. Although rare, the presence of cavitary disease in patients with HIV infection and M kansasii independently predicts worse outcome. The diversity in the radiographic presentation of M kansasii lung disease implies that clinicians should obtain sputum mycobacterial culture samples from any patient with HIV infection and an abnormal chest radiograph finding.",
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AU - Gotway, Michael

AU - Lee, Theodore J.

AU - Gonzalez, Leah C.

AU - Morris, Alison

AU - Webb, W. Richard

AU - Osmond, Dennis H.

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N2 - Background: Published criteria for the diagnosis of Mycobacterium kansasii lung disease require the presence of clinical symptoms, positive microbiologic results, and radiographic abnormalities. In patients with HIV infection, the radiographic findings of M kansasii lung disease are not well described. Methods: Medical records and chest radiographs of all patients with HIV infection and at least one respiratory specimen culture positive for M kansasii at San Francisco General Hospital between December 1989 and July 2002 were reviewed. Results: Chest radiographic results were abnormal in 75 of 83 patients (90%) included in the study. Radiographic abnormalities were diverse, with consolidation (66%) and nodules (42%) as the most frequent findings. The mid or lower lung zones were involved in 89% of patients. The pattern of radiographic abnormalities did not differ based on acid-fast bacilli smear status, the presence or absence of coexisting pulmonary infections, or CD4+ T-lymphocyte count. In multivariate Cox regression analysis, cavitation was the only radiographic abnormality independently associated with mortality (hazard ratio, 4.8; 95% confidence interval, 1.2 to 19.6). Conclusion: Patients with HIV infection and M kansasii lung disease present with diverse radiographic patterns, most commonly consolidation and nodules predominantly located in the mid and lower lung zones. This finding is in contrast to the upper-lobe cavitary presentation described in patients without HIV infection. Although rare, the presence of cavitary disease in patients with HIV infection and M kansasii independently predicts worse outcome. The diversity in the radiographic presentation of M kansasii lung disease implies that clinicians should obtain sputum mycobacterial culture samples from any patient with HIV infection and an abnormal chest radiograph finding.

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