Desmoplastic Melanoma of the Head and Neck: Histopathologic and Immunohistochemical Study of 28 Cases

Paul A. Kay; A. Daniel Pinheiro; Christine M. Lohse; V. Shane Pankratz; Kerry D. Olsen; Jean E. Lewis; Antonio G. Nascimento

doi:10.1177/106689690401200103

Desmoplastic Melanoma of the Head and Neck: Histopathologic and Immunohistochemical Study of 28 Cases

Paul A. Kay, A. Daniel Pinheiro, Christine M. Lohse, V. Shane Pankratz, Kerry D. Olsen, Jean E. Lewis, Antonio G. Nascimento

Quantitative Health Sciences

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29 Scopus citations

Abstract

Studies of the immunohistochemical profiles and clinical course of desmoplastic melanoma have produced conflicting results. We identified 28 cases of desmoplastic melanoma after a search of our files for spindle cell neoplasms of the head and neck from 1960 through 1995. The 17 male (61%) and 11 female (39%) patients averaged 65 years of age. The cheek was the most common location (12 cases, 43%). The average length of follow-up was 5 years. Overall 5-year survival rate was 46%. Melan A and tyrosinase positivity (P = 0.0195), smooth muscle actin positivity (P = 0.0328), tumor size (P = 0.0297), and tumor thickness (P = 0.0419) were significantly associated with local progression-free survival. No histologic or immunohistochemical marker was associated with overall or metastasis-free survival.

Original language	English (US)
Pages (from-to)	17-24
Number of pages	8
Journal	International Journal of Surgical Pathology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1177/106689690401200103
State	Published - Jan 2004

Keywords

Desmoplastic melanoma
Head and neck neoplasm
Melanoma

ASJC Scopus subject areas

Anatomy
Surgery
Pathology and Forensic Medicine

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10.1177/106689690401200103

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title = "Desmoplastic Melanoma of the Head and Neck: Histopathologic and Immunohistochemical Study of 28 Cases",

abstract = "Studies of the immunohistochemical profiles and clinical course of desmoplastic melanoma have produced conflicting results. We identified 28 cases of desmoplastic melanoma after a search of our files for spindle cell neoplasms of the head and neck from 1960 through 1995. The 17 male (61%) and 11 female (39%) patients averaged 65 years of age. The cheek was the most common location (12 cases, 43%). The average length of follow-up was 5 years. Overall 5-year survival rate was 46%. Melan A and tyrosinase positivity (P = 0.0195), smooth muscle actin positivity (P = 0.0328), tumor size (P = 0.0297), and tumor thickness (P = 0.0419) were significantly associated with local progression-free survival. No histologic or immunohistochemical marker was associated with overall or metastasis-free survival.",

keywords = "Desmoplastic melanoma, Head and neck neoplasm, Melanoma",

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T2 - Histopathologic and Immunohistochemical Study of 28 Cases

AU - Kay, Paul A.

AU - Pinheiro, A. Daniel

AU - Lohse, Christine M.

AU - Pankratz, V. Shane

AU - Olsen, Kerry D.

AU - Lewis, Jean E.

AU - Nascimento, Antonio G.

PY - 2004/1

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N2 - Studies of the immunohistochemical profiles and clinical course of desmoplastic melanoma have produced conflicting results. We identified 28 cases of desmoplastic melanoma after a search of our files for spindle cell neoplasms of the head and neck from 1960 through 1995. The 17 male (61%) and 11 female (39%) patients averaged 65 years of age. The cheek was the most common location (12 cases, 43%). The average length of follow-up was 5 years. Overall 5-year survival rate was 46%. Melan A and tyrosinase positivity (P = 0.0195), smooth muscle actin positivity (P = 0.0328), tumor size (P = 0.0297), and tumor thickness (P = 0.0419) were significantly associated with local progression-free survival. No histologic or immunohistochemical marker was associated with overall or metastasis-free survival.

AB - Studies of the immunohistochemical profiles and clinical course of desmoplastic melanoma have produced conflicting results. We identified 28 cases of desmoplastic melanoma after a search of our files for spindle cell neoplasms of the head and neck from 1960 through 1995. The 17 male (61%) and 11 female (39%) patients averaged 65 years of age. The cheek was the most common location (12 cases, 43%). The average length of follow-up was 5 years. Overall 5-year survival rate was 46%. Melan A and tyrosinase positivity (P = 0.0195), smooth muscle actin positivity (P = 0.0328), tumor size (P = 0.0297), and tumor thickness (P = 0.0419) were significantly associated with local progression-free survival. No histologic or immunohistochemical marker was associated with overall or metastasis-free survival.

KW - Desmoplastic melanoma

KW - Head and neck neoplasm

KW - Melanoma

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Desmoplastic Melanoma of the Head and Neck: Histopathologic and Immunohistochemical Study of 28 Cases

Abstract

Keywords

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