Desmoplastic Melanoma of the Head and Neck: Histopathologic and Immunohistochemical Study of 28 Cases

Paul A. Kay, A. Daniel Pinheiro, Christine M. Lohse, V. Shane Pankratz, Kerry D. Olsen, Jean E. Lewis, Antonio G. Nascimento

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Studies of the immunohistochemical profiles and clinical course of desmoplastic melanoma have produced conflicting results. We identified 28 cases of desmoplastic melanoma after a search of our files for spindle cell neoplasms of the head and neck from 1960 through 1995. The 17 male (61%) and 11 female (39%) patients averaged 65 years of age. The cheek was the most common location (12 cases, 43%). The average length of follow-up was 5 years. Overall 5-year survival rate was 46%. Melan A and tyrosinase positivity (P = 0.0195), smooth muscle actin positivity (P = 0.0328), tumor size (P = 0.0297), and tumor thickness (P = 0.0419) were significantly associated with local progression-free survival. No histologic or immunohistochemical marker was associated with overall or metastasis-free survival.

Original languageEnglish (US)
Pages (from-to)17-24
Number of pages8
JournalInternational Journal of Surgical Pathology
Volume12
Issue number1
DOIs
StatePublished - Jan 2004

Keywords

  • Desmoplastic melanoma
  • Head and neck neoplasm
  • Melanoma

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Desmoplastic Melanoma of the Head and Neck: Histopathologic and Immunohistochemical Study of 28 Cases'. Together they form a unique fingerprint.

Cite this