Desmoid tumors of the head and neck

A therapeutic challenge

Eelco De Bree, Odysseas Zoras, Jennifer L. Hunt, Robert P. Takes, Carlos Suárez, William M. Mendenhall, Michael L. Hinni, Juan P. Rodrigo, Ashok R. Shaha, Alessandra Rinaldo, Alfio Ferlito, Remco De Bree

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Desmoid tumor, or aggressive fibromatosis, is a rare, histologically benign, fibroblastic lesion that infrequently presents in the head and neck. Desmoid tumors often grow locally, invasively, and may, in rare instances, be fatal secondary to invasion into critical structures, such as airway or major vessels. The most common treatment is surgery, but desmoid tumors are characteristically associated with a high local recurrence rate after resection. Although the margin status seems to be of importance, operations that avoid function loss and esthetic disfigurement should be the primary goal. The efficacy of postoperative radiotherapy is controversial. Its potential benefit should be carefully balanced against possible radiation-induced adverse effects. Alternative treatment modalities, such as primary radiotherapy and medical treatment or a wait-and-see policy, may be preferable to mutilating surgery. Considering all the aforementioned, it seems obvious that desmoid tumors of the head and neck present a therapeutic challenge and require an individualized approach.

Original languageEnglish (US)
Pages (from-to)1517-1526
Number of pages10
JournalHead and Neck
Volume36
Issue number10
DOIs
StatePublished - 2014

Fingerprint

Aggressive Fibromatosis
Neck
Head
Neoplasms
Radiotherapy
Therapeutics
Esthetics
Radiation
Recurrence

Keywords

  • Aggressive fibromatosis
  • Desmoid
  • Desmoid tumor
  • Head and neck

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

De Bree, E., Zoras, O., Hunt, J. L., Takes, R. P., Suárez, C., Mendenhall, W. M., ... De Bree, R. (2014). Desmoid tumors of the head and neck: A therapeutic challenge. Head and Neck, 36(10), 1517-1526. https://doi.org/10.1002/hed.23496

Desmoid tumors of the head and neck : A therapeutic challenge. / De Bree, Eelco; Zoras, Odysseas; Hunt, Jennifer L.; Takes, Robert P.; Suárez, Carlos; Mendenhall, William M.; Hinni, Michael L.; Rodrigo, Juan P.; Shaha, Ashok R.; Rinaldo, Alessandra; Ferlito, Alfio; De Bree, Remco.

In: Head and Neck, Vol. 36, No. 10, 2014, p. 1517-1526.

Research output: Contribution to journalArticle

De Bree, E, Zoras, O, Hunt, JL, Takes, RP, Suárez, C, Mendenhall, WM, Hinni, ML, Rodrigo, JP, Shaha, AR, Rinaldo, A, Ferlito, A & De Bree, R 2014, 'Desmoid tumors of the head and neck: A therapeutic challenge', Head and Neck, vol. 36, no. 10, pp. 1517-1526. https://doi.org/10.1002/hed.23496
De Bree E, Zoras O, Hunt JL, Takes RP, Suárez C, Mendenhall WM et al. Desmoid tumors of the head and neck: A therapeutic challenge. Head and Neck. 2014;36(10):1517-1526. https://doi.org/10.1002/hed.23496
De Bree, Eelco ; Zoras, Odysseas ; Hunt, Jennifer L. ; Takes, Robert P. ; Suárez, Carlos ; Mendenhall, William M. ; Hinni, Michael L. ; Rodrigo, Juan P. ; Shaha, Ashok R. ; Rinaldo, Alessandra ; Ferlito, Alfio ; De Bree, Remco. / Desmoid tumors of the head and neck : A therapeutic challenge. In: Head and Neck. 2014 ; Vol. 36, No. 10. pp. 1517-1526.
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