TY - JOUR
T1 - Designing therapeutic clinical trials for older and frail adults with cancer
T2 - U13 conference recommendations
AU - Hurria, Arti
AU - Dale, William
AU - Mooney, Margaret
AU - Rowland, Julia H.
AU - Ballman, Karla V.
AU - Cohen, Harvey J.
AU - Muss, Hyman B.
AU - Schilsky, Richard L.
AU - Ferrell, Betty
AU - Extermann, Martine
AU - Schmader, Kenneth E.
AU - Mohile, Supriya G.
PY - 2014/8/20
Y1 - 2014/8/20
N2 - A majority of cancer diagnoses and deaths occur in patients age ≥ 65 years. With the aging of the US population, the number of older adults with cancer will grow. Although the coming wave of older patients with cancer was anticipated in the early 1980s, when the need for more research on the cancer-aging interface was recognized, many knowledge gaps remain when it comes to treating older and/or frailer patients with cancer. Relatively little is known about the best way to balance the risks and benefits of existing cancer therapies in older patients; however, these patients continue to be underrepresented in clinical trials. Furthermore, the available clinical trials often do not include end points pertinent to the older adult population, such as preservation of function, cognition, and independence. As part of its ongoing effort to advance research in the field of geriatric oncology, the Cancer and Aging Research Group held a conference in November 2012 in collaboration with the National Cancer Institute, the National Institute on Aging, and the Alliance for Clinical Trials in Oncology. The goal was to develop recommendations and establish research guidelines for the design and implementation of therapeutic clinical trials for older and/or frail adults. The conference sought to identify knowledge gaps in cancer clinical trials for older adults and propose clinical trial designs to fill these gaps. The ultimate goal of this conference series is to develop research that will lead to evidence-based care for older and/or frail adults with cancer.
AB - A majority of cancer diagnoses and deaths occur in patients age ≥ 65 years. With the aging of the US population, the number of older adults with cancer will grow. Although the coming wave of older patients with cancer was anticipated in the early 1980s, when the need for more research on the cancer-aging interface was recognized, many knowledge gaps remain when it comes to treating older and/or frailer patients with cancer. Relatively little is known about the best way to balance the risks and benefits of existing cancer therapies in older patients; however, these patients continue to be underrepresented in clinical trials. Furthermore, the available clinical trials often do not include end points pertinent to the older adult population, such as preservation of function, cognition, and independence. As part of its ongoing effort to advance research in the field of geriatric oncology, the Cancer and Aging Research Group held a conference in November 2012 in collaboration with the National Cancer Institute, the National Institute on Aging, and the Alliance for Clinical Trials in Oncology. The goal was to develop recommendations and establish research guidelines for the design and implementation of therapeutic clinical trials for older and/or frail adults. The conference sought to identify knowledge gaps in cancer clinical trials for older adults and propose clinical trial designs to fill these gaps. The ultimate goal of this conference series is to develop research that will lead to evidence-based care for older and/or frail adults with cancer.
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UR - http://www.scopus.com/inward/citedby.url?scp=84906241905&partnerID=8YFLogxK
U2 - 10.1200/JCO.2013.55.0418
DO - 10.1200/JCO.2013.55.0418
M3 - Review article
C2 - 25071116
AN - SCOPUS:84906241905
SN - 0732-183X
VL - 32
SP - 2587
EP - 2594
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 24
ER -