Design and initial performance evaluation of DbPET2, an intermediate generation breast PET prototype

Andrea Ferrero, Qiyu Peng, Felipe Godinez, Abhijit J. Chaudhari, Chinh Vu, Woon Seng Choong, William W. Moses, Ramsey D. Badawi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The combined effort of several laboratories at our institution resulted in the building of the first dedicated, breast PET/CT prototype. Ongoing clinical trials for breast cancer diagnosis and assessment of response to treatment underlined the need of a second generation prototype with improved sensitivity and spatial resolution. The goals of the new prototype are to reduce scan time and partial volume effects on quantitative measurements of small lesions. Several designs have been proposed by our group and are currently under investigation at different levels. In this work, we present the complete characterization of a detector module for an intermediate generation breast PET prototype, together with its design and assembly. The proposed design consists of two heads, shaped around the circumference of a circle of radius 26 cm. Each head is formed by 2 rows of 8 modules each, each module consisting in a 14x14 array of unpolished LSO crystals, read out by a position sensitive photomultiplier tube (PSPMT). Crystal pitch is 1.5 mm. A complete characterization of two detectors modules in coincidence resulted in an energy resolution of 25.2%, a timing resolution of 2.4 ns and an average intrinsic spatial resolution for a central row in the array of 1.26 mm. The two detector heads are now fully assembled and connected to the electronics suite for data processing. Modification of the system electronics is underways and the first floods, showing excellent position encoding, are presented. A thorough evaluation of system performance will be completed in the next few months. We plan to combine this scanner with a third generation breast CT system currently under parallel development to form a new generation, dedicated breast PET/CT scanner.

Original languageEnglish (US)
Title of host publication2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3256-3259
Number of pages4
ISBN (Print)9781467301183
DOIs
StatePublished - Jan 1 2011
Event2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 - Valencia, Spain
Duration: Oct 23 2011Oct 29 2011

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Conference

Conference2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
CountrySpain
CityValencia
Period10/23/1110/29/11

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Ferrero, A., Peng, Q., Godinez, F., Chaudhari, A. J., Vu, C., Choong, W. S., Moses, W. W., & Badawi, R. D. (2011). Design and initial performance evaluation of DbPET2, an intermediate generation breast PET prototype. In 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 (pp. 3256-3259). [6152585] (IEEE Nuclear Science Symposium Conference Record). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2011.6152585